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1.
Parasitol Int ; 86: 102481, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34688883

RESUMO

Dirofilariasis is an emerging zoonosis caused by nematodes of the genus Dirofilaria, most often D. repens and D. immitis. The main final hosts and reservoirs of pathogens are dogs. The intermediate hosts and vectors of infection are female mosquitoes (Culicidae). Human is an accidental host in which the parasite does not usually mature. Over the past 20 years, the range of Dirofilaria spp. in Europe has expanded. We present an unusual case of multifocal dirofilariasis of mixed subcutaneous-ocular course caused by D. repens in a 52-year-old Polish patient who was probably infected in Spain or Croatia, where she stayed one year before the onset of symptoms. Surgical removal of the nematodes followed by treatment with Ivermectin in a single dose of 1200 µg and Doxycycline 200 mg daily for 7 days resulted in complete recovery. We believe that all cases of human dirofilariasis, especially in countries where the disease is not frequent at present, should be registered for epidemiological purposes. Moreover, due to the widening of the range of D. repens and D. immitis occurrence and the possibility of atypical courses of infection with both nematodes, diagnostics should include the species identification of the parasite.


Assuntos
Dirofilaria repens/isolamento & purificação , Dirofilariose/diagnóstico , Oftalmopatias/diagnóstico , Dermatopatias/diagnóstico , Animais , Antiparasitários/administração & dosagem , Croácia , Dirofilariose/tratamento farmacológico , Dirofilariose/parasitologia , Dirofilariose/cirurgia , Doxiciclina/administração & dosagem , Oftalmopatias/tratamento farmacológico , Oftalmopatias/parasitologia , Oftalmopatias/cirurgia , Feminino , Humanos , Ivermectina/administração & dosagem , Pessoa de Meia-Idade , Polônia , Dermatopatias/tratamento farmacológico , Dermatopatias/parasitologia , Dermatopatias/cirurgia , Espanha , Viagem , Resultado do Tratamento
2.
Dermatol Clin ; 40(1): 73-81, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34799037

RESUMO

The understanding of melanocytes is fundamental to the study of dermatology. These dendritic cells underly the most feared primary cutaneous malignancy, fuel escalating progress in immunotherapy strategies, and invariably underlie entire socioeconomic constructs consciously or unconsciously based on skin tone. Various ethno-genotypes combine with increasing frequency over time, increasing the diversity of skin types that may present with dermatologic diagnoses. Understanding the biology of a variety of skin tones and ethnic practices congruent with distribution of skin tone is invaluable to any physician who wishes to practice efficient and expert care, especially to pediatric patients of this category.


Assuntos
Dermatologia , Neoplasias , Dermatopatias , Criança , Grupos Étnicos , Humanos , Pele , Dermatopatias/terapia , Pigmentação da Pele
3.
Dermatol Clin ; 40(1): 83-93, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34799038

RESUMO

Many dermatologic conditions common in the pediatric population may have unique presentations in skin of color or occur with greater incidence. This may be due to ethnic origin, socioeconomic factors, or other influences. Awareness of the potential variations in skin of color may enhance prompt diagnosis, appropriate treatment, and/or reassurance as indicated.


Assuntos
Dermatologia , Dermatopatias , Criança , Grupos Étnicos , Humanos , Pele , Dermatopatias/epidemiologia , Pigmentação da Pele
4.
Dermatol Clin ; 40(1): 95-102, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34799040

RESUMO

Pediatric dermatology is an incredibly rewarding field. Children are resilient and funny and just want to know that you are advocating for their best interests. Teaming up with children and their parents can lead to fantastic therapeutic alliances and success. The author has divided this chapter based on a handful of common pediatric dermatologic diseases and what he sees as some of the main clinical and therapeutic tips and tricks that have helped him in his practice.


Assuntos
Dermatologia , Dermatopatias , Criança , Humanos , Dermatopatias/terapia
5.
Pan Afr Med J ; 39: 286, 2021.
Artigo em Francês | MEDLINE | ID: mdl-34754363

RESUMO

Naevus unius lateris is a rare congenital hamartoma, originating from the ectoderm. It is considered as a verruquous variant of the epidermal naevus. Given its extensive unilateral distribution, it is frequently associated with neurological, musculoskeletal, auditory and visual abnormalities. We here report the case of a 9-year-old child with nevus unius lateris associated with neurological and eye abnormalities.


Assuntos
Hamartoma/diagnóstico , Nevo/diagnóstico , Dermatopatias/diagnóstico , Criança , Anormalidades do Olho/diagnóstico , Hamartoma/congênito , Hamartoma/patologia , Humanos , Masculino , Nevo/congênito , Nevo/patologia , Dermatopatias/congênito , Dermatopatias/patologia
6.
Artigo em Inglês | MEDLINE | ID: mdl-34769769

RESUMO

BACKGROUND: In the course of plaque psoriasis, tissue resident memory cells (TRM) are responsible for the phenomenon of "immune memory" of lesions, i.e., the appearance of recurrences of lesions in the same location, as well as Koebner phenomenon. We present results determining the location and amount of TRM in psoriatic lesions in patients suffering from plaque psoriasis, as well as an analysis of the relationship between TRM markers expression and the duration and severity of the disease. METHODS: TRM markers (CD4, CD8, CD103, CD69, CD49, CXCR6) and tissue expression of cytokines (IL-17, IL-22) in the lesional psoriatic skin of 32 patients compared with 10 healthy skin samples were evaluated by immunohistochemistry. RESULTS: The presence of TRM markers in both the epidermis and skin with psoriatic eruptions was demonstrated in much higher amounts compared with the skin of healthy volunteers. A significant positive relationship was demonstrated between the expression of TRM markers in patients with plaque psoriasis and the duration of skin lesions. There was no relationship between the amount of TRM and the severity of plaque psoriasis. CONCLUSIONS: A thorough understanding of the mechanisms responsible for the development and relapse of plaque psoriasis may contribute to the implementation of more effective therapies.


Assuntos
Psoríase , Dermatopatias , Voluntários Saudáveis , Humanos , Memória Imunológica , Pele
7.
Br J Nurs ; 30(21): 1232-1236, 2021 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-34839692

RESUMO

Advanced clinical practitioner (ACP) roles require a broad range of knowledge of both medical and surgical areas and the ability to work autonomously in a variety of settings. Despite around half of the UK adult population presenting with a skin condition requiring attention at some point, this is an area many ACPs feel unprepared to manage. However, due to the complexity and large number of potential diagnoses, it is imperative that ACPs develop their knowledge of skin conditions so that they can confidently conduct consultations with patients. This clinical review presents the key elements of patient consultation, history taking and assessment of the skin. This is designed to support novice ACPs, whether working in acute hospital settings or primary care, to develop an understanding of the key points that should be included when consulting with and assessing the skin of patients outwith the dermatology setting.


Assuntos
Profissionais de Enfermagem , Dermatopatias , Adulto , Humanos , Atenção Primária à Saúde , Encaminhamento e Consulta , Dermatopatias/diagnóstico , Dermatopatias/terapia
8.
Laeknabladid ; 107(12): 597-602, 2021 Dec.
Artigo em Islandês | MEDLINE | ID: mdl-34821576

RESUMO

In the summer of 2020, an elderly woman in her eighties sought medical attention due to headache and visual disturbances. The diagnosis was unclear, she became blind on both eyes and developed extended scalp necrosis. Later it was clear that these symptoms were due to accelerating symptoms of giant cell arteritis (GCA). GCA is one of the most common disease form of vasculitis and can have various symptoms. In this report, we describe a case of an advanced disease course, discuss the main symptoms, diagnosis and treatment.


Assuntos
Arterite de Células Gigantes , Dermatopatias , Idoso , Cegueira/diagnóstico , Cegueira/etiologia , Feminino , Arterite de Células Gigantes/complicações , Arterite de Células Gigantes/diagnóstico , Humanos , Necrose , Couro Cabeludo
9.
Nursing ; 51(12): 20-26, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34807856

RESUMO

ABSTRACT: Pulmonary sarcoidosis is a multisystem disease characterized by sarcoid granulomas, vasculitis, and degrees of necrosis with unknown etiology. This article discusses the pathophysiology of sarcoidosis and its medical and nursing management. A case presentation highlights some long-term concerns with this chronic disease.


Assuntos
Enfermeiras e Enfermeiros , Sarcoidose Pulmonar , Sarcoidose , Dermatopatias , Granuloma , Humanos , Sarcoidose/diagnóstico , Sarcoidose Pulmonar/diagnóstico
10.
Clin Dermatol ; 39(4): 555-562, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34809761

RESUMO

Dermatology is one of the few visual specialties; much can be seen with the naked eye, yet many tools and devices can facilitate the diagnosis of cutaneous maladies. There has been significant progress in diagnostic techniques in recent decades with the advent of artificial intelligence and teledermatology. Such advancements reflect principles of long-standing aids, whereas others embody novel techniques and concepts. These bedside tools range from simple magnifiers and binocular loupes to reflectance confocal microscopes and ultrasounds. The cornerstone diagnostic techniques, including the potassium hydroxide examination and the Tzanck smear, remain highly useful. Although visual examination often permits an accurate diagnosis of a skin disease, the clinician is now even further equipped. Just as the microscope did 4 centuries ago, newer advances will continue to revolutionize the practice of medicine.


Assuntos
Dermatologia , Dermatopatias , Inteligência Artificial , Humanos , Pele , Dermatopatias/diagnóstico , Coloração e Rotulagem
11.
Clin Dermatol ; 39(4): 624-634, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34809767

RESUMO

During the past decade, noninvasive imaging has emerged as a valuable tool in clinical dermatology and dermatologic research. Optical coherence tomography (OCT) is one such type of noninvasive imaging. OCT uses the principle of interferometry to produce real-time images. A low-power diode laser shines infrared light onto tissues, which reflects back to an optical fiber interferometer. Using time delay and the backscattered light intensity, a two-dimensional image akin to an ultrasound is rendered. We review the history, types, and modalities of OCT, plus the many applications of frequency domain, high definition, and dynamic OCT in practice, including its utility in diagnosis, monitoring, and grading disease severity in a variety of cutaneous conditions.


Assuntos
Dermatopatias , Tomografia de Coerência Óptica , Humanos
12.
Clin Dermatol ; 39(4): 635-642, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34809768

RESUMO

The dermatoscope has gained tremendous popularity among dermatologists as an adjunctive tool to better visualize subsurface structures and identify patterns that may improve the diagnosis of a wide range of skin diseases. Initially, the pigmented lesion experts who were the early adopters promoted the use of the dermatoscope to increase diagnostic accuracy of early melanomas and decrease the harvesting of benign lesions. With current near universal adoption of the diagnostic technique by dermatologists, the dermatoscope is now employed to help identify a wide variety of inflammatory, infectious, and vascular conditions of the skin, hair, and nails, resulting in the emergence of several branches of dermatoscopy-inflammoscopy, trichoscopy, onychoscopy, and entodermoscopy. The future of dermatoscopy will involve incorporation of artificial intelligence that will make the assessment process increasingly objective, more accurate, and universally available. Despite the wide acceptance and adoption of dermatoscopy, the overall impact of its widespread use still remains unclear, whether it has decreased biopsy rates of benign lesions, reduced health care costs, or improved patient outcomes.


Assuntos
Melanoma , Dermatopatias , Neoplasias Cutâneas , Inteligência Artificial , Dermoscopia , Humanos , Melanoma/diagnóstico por imagem , Dermatopatias/diagnóstico por imagem , Neoplasias Cutâneas/diagnóstico por imagem
13.
Clin Dermatol ; 39(4): 667-672, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34809771

RESUMO

As medicine enters the era of artificial intelligence (AI)-augmented practice, dermatology is beginning to witness the integration of AI into the daily practice, particularly in the areas of diagnosis, prognosis, and treatment of skin diseases. Many of the current electronic medical records that dermatologists have incorporated provide guidance in billing, a form of AI at work. The recent advances in visual recognition AI make application and integration of the technology particularly suited for perceptual specialties such as radiology and dermatology. In dermatology, AI is poised to improve the efficiency and accuracy of traditional diagnostic approaches, including visual examination, skin biopsy, and histopathologic examination. This review highlights the current progress of AI in dermatology and provides a basic overview of the technology.


Assuntos
Dermatologia , Dermatopatias , Inteligência Artificial , Biópsia , Humanos , Prognóstico , Dermatopatias/diagnóstico , Dermatopatias/terapia
14.
Clin Dermatol ; 39(4): 707-709, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34809777

RESUMO

Since the COVID-19 outbreak, teledermatology services have become an integral part of our daily practice. In this study, we compared three practice models of an academic department in an urban setting: 1) in-person only, 2) teledermatology only, and 3) hybrid of in-person and teledermatology. Our study demonstrated that older patients prefer in-person visits over teledermatology visits, while non-English-speaking patients prefer teledermatology visits over in-person visits. In addition, teledermatology services can be better utilized for evaluation of acne and psoriasis, as these diagnoses do not require in-person reevaluation, unlike the evaluation of concerning lesions. Considering these findings, our study highlights the need to continuously examine our practice models to understand patient preferences, overcome practice-driven barriers, and ensure the sound allocation of limited health care resources.


Assuntos
COVID-19 , Dermatologia , Dermatopatias , Telemedicina , Humanos , SARS-CoV-2
15.
Minerva Surg ; 76(5): 423-428, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34814654

RESUMO

BACKGROUND: The ostomy patient's quality of life also depends on their peristomal health and thus first and foremost on keeping healthy peristomal skin. This is by no means an easy task, given that the incidence of peristomal skin disorders can be a factor in up to 80% of cases. Over the past 15 years, several tools have been developed to classify peristomal skin lesions to facilitate the management of the problem. These tools, however, meet the needs of healthcare professionals and those of patients. Hence the decision to work on an advanced version of the SACS©, currently the most widely used tool, with the setting up of the SACS Evolution Consensus Group. METHODS: By applying the simplified Delphi method, the SACS Evolution Consensus Group critically re-read what had been garnered from the literature in the light of their personal clinical experience, identified the key issues to be addressed, and processed and refined the relevant statements. This made it possible to achieve the challenging objective of creating a peristomal health tool to help prevent peristomal skin lesions. RESULTS: SACS Evolution is, indeed, a promising tool for preventing peristomal lesions. It is structured on two different levels, one for the patient and one for the healthcare professional, each characterized by specific language and based on an innovative concept of healthy peristomal skin, which is essential for those who work on peristomal health. CONCLUSIONS: The SACS Evolution Consensus Group thus aims to validate this peristomal health tool and has already started a validation process so that the tool can be used in clinical practice.


Assuntos
Estomia , Dermatopatias , Humanos , Qualidade de Vida , Pele , Higiene da Pele , Dermatopatias/prevenção & controle
16.
Clin Dermatol ; 39(5): 829-839, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34785010

RESUMO

The microbiome plays a significant role in human health, homeostasis, immune system, and disease pathogenesis. Disrupted communication between the microbiome and host has been extensively studied in gastrointestinal diseases. To a lesser extent, there is emerging research on the skin microbiome and its connection with the gut, referred to as the gut-skin axis and its effects on dermatologic conditions. A basic overview will be provided of the gut and skin microbiome with a focus on the impact of this connection on cutaneous diseases, such as psoriasis, atopic dermatitis, rosacea, acne vulgaris, photoaging, and cutaneous wounds. In addition, we shall discuss nutrition-based approaches mediated through the gut-skin axis and topical treatments that could serve as potential adjunctive management by manipulation of the microbiome. In particular, there is a growing body of research on oral probiotics, prebiotics, and dietary modifications that may help improve symptoms for a variety of dermatologic conditions in select demographic groups.


Assuntos
Dermatite Atópica , Microbiota , Probióticos , Dermatopatias , Humanos , Pele
17.
Clin Dermatol ; 39(5): 920-926, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34785023

RESUMO

An increasing body of evidence has been produced in a very limited period to improve the understanding of skin involvement in the current coronavirus 2019 disease pandemic, and how this novel disease affects the management of dermatologic patients. A little explored area is represented by the therapeutic approach adopted for the different skin manifestations associated with the infection. An overview of the current scenario is provided, through review of the English-language literature published until October 30, 2020, and comparison with the personal experience of the authors. As dermatologists, our primary aim is to support patients with the highest standard of care and relieve suffering, even with lesions not life-threatening. With asymptomatic COVID-19 patients, patient discomfort related to skin lesions should not be undervalued and intervention to accelerate healing should be provided. Consensus protocols are warranted to assess the best skin-targeted treatments in COVID-19 patients.


Assuntos
COVID-19 , Dermatopatias , Consenso , Humanos , Pandemias , SARS-CoV-2 , Dermatopatias/tratamento farmacológico , Dermatopatias/etiologia
19.
Rev Med Chil ; 149(5): 747-757, 2021 May.
Artigo em Espanhol | MEDLINE | ID: mdl-34751328

RESUMO

Monoclonal gammopathies of uncertain significance (MGUS) correspond to pre-malignant hematological disorders characterized by the production of a monoclonal protein and infiltration of less than 10% of the bone marrow by plasma cells. Its importance lies in the risk of progression to malignant disorders and in the association with different renal, neurological and skin manifestations. There are pathophysiological mechanisms that support a causal relationship between monoclonal gammopathies (MGs) and different skin diseases, such as type I cryoglobulinemia (CG), primary systemic amyloidosis (PSA) or necrobiotic xanthogranuloma (NXG). However, there is a group of skin diseases associated with MGs whose pathogenesis has not been elucidated. In this context, the role of the dermatologist is crucial in the suspicion of different haematological disorders based on skin manifestations and in the multidisciplinary treatment of these patients. In this article, we carry out an exhaustive review of the literature published in this area and propose a screening algorithm for MGs in patients with specific skin diseases.


Assuntos
Amiloidose de Cadeia Leve de Imunoglobulina , Gamopatia Monoclonal de Significância Indeterminada , Paraproteinemias , Dermatopatias , Medula Óssea , Humanos , Paraproteinemias/complicações , Dermatopatias/etiologia
20.
Cutis ; 108(2): 78-83, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34735317

RESUMO

Complementary alternative medicine (CAM) is a rapidly emerging field with prevalent use reported among dermatologic patients. However, the effectiveness and safety among different treatments notably varies. A review of the current literature regarding CAM for the treatment of 3 common conditions-atopic dermatitis (AD), psoriasis, and alopecia areata (AA)-is reported to help familiarize dermatologists with the most up-to-date information on this topic.


Assuntos
Alopecia em Áreas , Terapias Complementares , Dermatite Atópica , Dermatopatias , Dermatite Atópica/terapia , Suplementos Nutricionais , Humanos , Dermatopatias/terapia
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