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1.
BMC Public Health ; 24(1): 1502, 2024 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-38840150

RESUMO

BACKGROUND: A person's sense of coherence (SoC) is likely to affect coping when exposed to a life changing event like the COVID -19 pandemic, which impacted the older population especially hard, an age group that already suffers from a lot of mental illness. Thus, the aim of this study was to investigate the associations between SoC and mental health in older adults using both screening scales and hair cortisol concentrations (HCC). METHOD: A cross-sectional design studying a cohort of 70-80 years old, N = 260, set in Swedish primary care during the pandemic years 2021-2022. Instruments used are sense of coherence 13 (SoC-13), EQ-5D-3L, Geriatric depression scale 20 (GDS-20), Hospital anxiety and depression scale (HADS), and Perceived stress scale 10 (PSS-10). Sociodemography and factors concerning SoC, and mental health are explored. HCC are measured using radioimmunoassay. Outcome measures are factors independently associated with SoC. Linear regression models were performed with SoC as dependent variable, and priory path analyses explored whether associations with SoC were direct, or indirect via anxiety. RESULTS: SoC was significantly associated with anxiety (p < 0.001), perceived economic status (p = 0.003), belief in the future (p = 0.001), and perceived negative mental effect from the COVID -19 pandemic (p = 0.002). The latter was 96% indirectly associated with SoC (p < 0.001), whereas perceived economic status together with belief in the future was 82% directly associated with SoC (p = 0.17). HCC and sex were not significantly associated with SoC, but, noticeably, high HCC was equally distributed between women and men. Women reported significantly lower quality of life (p = 0.03), and more symptoms of anxiety (p = 0.001) and depression (p < 0.001). CONCLUSION: Anxiety, belief in the future, perceived negative effect on mental health due to the pandemic, and perceived economic status were significantly associated with SoC. Anxiety is suggested to be important in explaining the association between perceived negative mental effect from the COVID-19 pandemic and SoC. Women reported significantly poorer mental health and life quality than men.


Assuntos
COVID-19 , Cabelo , Hidrocortisona , Saúde Mental , Senso de Coerência , Humanos , COVID-19/psicologia , COVID-19/epidemiologia , Estudos Transversais , Masculino , Idoso , Cabelo/química , Feminino , Hidrocortisona/análise , Hidrocortisona/metabolismo , Idoso de 80 Anos ou mais , Suécia/epidemiologia , Ansiedade/epidemiologia , Depressão/epidemiologia , Depressão/psicologia
2.
Braz J Biol ; 84: e282174, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38836803

RESUMO

The elemental status of cattle is one of the important factors, which determine its growth, fertility, fetal development, meat and dairy production, etc. Therefore, the study of content of different elements in cattle organs and tissues and its correlation with cattle characteristics and diet is urgent task. It is also important to develop intravital and low-invasive methods to analyze element content in cattle to regulate its diet during lifetime. In the present work, we have studied the content and distribution of manganese in Hereford cattle from an ecologically clean zone of Western Siberia (Russia). 252 samples were taken from 31 bulls aged 15-18 months. They were collected from various livestock farms in the region and analyzed using atomic absorption spectrophotometry (organs and muscle tissue) and inductively coupled plasma atomic emission spectrometry (hair). The median values of manganese concentration obtained in natural moisture for hair, heart, kidneys, liver, lungs, muscles, spleen, testes, and brain were 25, 0.37, 1.0, 2.6, 0.4, 0.2, 0.4, 0.5, and 0.5 ppm. Accordingly, the concentration of manganese differs significantly in the organs and tissues of animals (H = 188.6, df = 8, p <0.0001). Statistically significant associations of manganese were revealed in pairs: liver-testis, hair-testis, spleen-testis, and heart-brain. The classification of organs and tissues of animals according to the level of content and variability of manganese is carried out. The concentration of manganese in the body is not uniform, most of all it is deposited in the hair and excretory organs of the liver and kidneys. In other organs and muscle tissues, the distribution of manganese is more even and is in the range of 0.2-0.5 ppm. The resulting ranges can be used as a guideline for Hereford cattle bred in Western Siberia.


Assuntos
Manganês , Espectrofotometria Atômica , Animais , Manganês/análise , Bovinos , Masculino , Sibéria , Cabelo/química , Distribuição Tecidual
4.
Dev Psychobiol ; 66(5): e22512, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38837366

RESUMO

The current study examined associations between parental adversities as experienced in adolescence and hair cortisol concentration (HCC) 26 years later (n = 47). Specifically, bivariate correlations and linear regressions were used to examine harsh parenting as well as parental economic pressure, emotional distress, and body mass index (BMI) when their adolescent was between 15 and 16 years old (parent average age 43). HCC was measured when the adolescent was an adult (average 42 years old), at a similar age to when their parent(s) first participated in the study. We also assessed their economic pressure, emotional distress, obesity, and perceived stress in adulthood. For results across generations, parental economic pressure experienced during adolescence was significantly related to HCC when these adolescents were adults. None of the adult economic pressure, emotional distress, BMI, and perceived stress variables were associated with their HCC. Interestingly, there were significant associations among adult perceived stress, economic pressure, emotional distress, and obesity. Thus, the association between parental economic pressure and adult HCC is independent of adult adversities. Results highlight early economic adversity as a possible childhood stressor that has implications throughout the life course.


Assuntos
Experiências Adversas da Infância , Cabelo , Hidrocortisona , Humanos , Cabelo/química , Feminino , Masculino , Hidrocortisona/metabolismo , Hidrocortisona/análise , Adulto , Adolescente , Estresse Psicológico/metabolismo , Poder Familiar , Índice de Massa Corporal , Angústia Psicológica , Obesidade/metabolismo
5.
J Oleo Sci ; 73(6): 825-837, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38825536

RESUMO

Hair is important to our appearance as well as to protect our heads. Human hair mainly consists of proteins (80-85%), melanin pigments (0-5%), water (10-13%), and lipids (1-6%). The physicochemical properties of hair have been studied for over 100 years. However, they are not yet thoroughly understood. In this review, recent progress and the latest findings are summarized from the following three perspectives: structural characteristics, delivery and distribution of active ingredients, and hair as a template. The structural characteristics of hair have been mainly investigated by microscopic and/or spectroscopic techniques such as atomic force microscopy integrated with infrared spectroscopy (AFM-IR) and rheological measurements. The distribution of active ingredients has been generally evaluated through techniques such as nanoscale secondary ion mass spectrometry (NanoSIMS). And finally, attempts to explore the potential of hair to be used as a substrate for flexible device fabrication will be introduced.


Assuntos
Cabelo , Cabelo/química , Humanos , Microscopia de Força Atômica , Melaninas , Fenômenos Químicos , Espectrometria de Massa de Íon Secundário/métodos , Reologia , Espectrofotometria Infravermelho/métodos , Lipídeos/análise , Lipídeos/química , Água , Proteínas/análise
6.
PLoS One ; 19(6): e0304605, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38861499

RESUMO

Canine Alopecia X is a non-inflammatory hair loss disorder of unknown etiology that predominantly affects German Spitz dogs. Treatment modalities include hormone and/or melatonin supplementation and low trauma microneedling. Melatonin influences hair growth and pigmentation in several species and presents a low risk of adverse effects when used in dogs with Alopecia X. Photobiomodulation (PBM) is frequently used in human androgenetic alopecia and alopecia areata; despite this, PBM remains unexplored in canine Alopecia X. To address this knowledge gap, sixty dogs of both sexes will be randomly assigned to three groups: (i) melatonin only group (3 mg/Kg, n = 20); (ii) PBM only group (diode laser, wavelength 660nm, 100mw power, with 3 J/point, 2 sessions/week for 3 months, n = 20); (ii) PBM + melatonin group (n = 20). The objective is to determine the potential of PBM alone or in conjunction with melatonin supplementation in promoting hair regrowth (hair density and diameter) by means of dermatoscopy and planimetry over a period of 90 days.


Assuntos
Alopecia , Terapia com Luz de Baixa Intensidade , Melatonina , Animais , Melatonina/uso terapêutico , Melatonina/farmacologia , Cães , Terapia com Luz de Baixa Intensidade/métodos , Alopecia/tratamento farmacológico , Alopecia/radioterapia , Alopecia/veterinária , Masculino , Feminino , Método Duplo-Cego , Doenças do Cão/radioterapia , Cabelo/crescimento & desenvolvimento , Cabelo/efeitos dos fármacos
7.
Sci Rep ; 14(1): 13569, 2024 06 12.
Artigo em Inglês | MEDLINE | ID: mdl-38866844

RESUMO

Revolutionizing construction, the concrete blend seamlessly integrates human hair (HH) fibers and millet husk ash (MHA) as a sustainable alternative. By repurposing human hair for enhanced tensile strength and utilizing millet husk ash to replace sand, these materials not only reduce waste but also create a durable, eco-friendly solution. This groundbreaking methodology not only adheres to established structural criteria but also advances the concepts of the circular economy, representing a significant advancement towards environmentally sustainable and resilient building practices. The main purpose of the research is to investigate the fresh and mechanical characteristics of concrete blended with 10-40% MHA as a sand substitute and 0.5-2% HH fibers by applying response surface methodology modeling and optimization. A comprehensive study involved preparing 225 concrete specimens using a mix ratio of 1:1.5:3 with a water-to-cement ratio of 0.52, followed by a 28 day curing period. It was found that a blend of 30% MHA and 1% HH fibers gave the best compressive and splitting tensile strengths at 28 days, which were 33.88 MPa and 3.47 MPa, respectively. Additionally, the incorporation of increased proportions of MHA and HH fibers led to reductions in both the dry density and workability of the concrete. In addition, utilizing analysis of variance (ANOVA), response prediction models were created and verified with a significance level of 95%. The models' R2 values ranged from 72 to 99%. The study validated multi-objective optimization, showing 1% HH fiber and 30% MHA in concrete enhances strength, reduces waste, and promotes environmental sustainability, making it recommended for construction.


Assuntos
Materiais de Construção , Cabelo , Milhetes , Resistência à Tração , Humanos , Materiais de Construção/análise , Cabelo/química , Milhetes/química , Teste de Materiais , Força Compressiva
8.
Arch Dermatol Res ; 316(6): 336, 2024 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-38844670

RESUMO

Telogen effluvium is characterized by excessive hair shedding usually following a stressful event. Ferritin has been used in clinical practice as a biomarker of nonanemic iron deficiency in cases of telogen effluvium. During the years of the COVID19 pandemic, telogen effluvium was reported as a part of post covid manifestations. As ferritin was also a biomarker for inflammation in cases with covid infection, this study was designed to evaluate the value of ferritin in cases with postcovid telogen effluvium one hundred patients recovering from covid 19 for 4-12 weeks were included in the study, detailed drug and laboratory history was obtained and serum ferritin level was measured. the mean serum level of ferritin among telogen effluvium patients was significantly lower than controls (68.52 ± 126 and 137 ± 137.597 ug/L respectively). Patients with telogen effluvium used significantly more azithromycin and ivermectin and significantly less vitamin C, D, lactoferrin and zinc than the controls Although serum ferritin is lower among telogen effluvium patients, it was still higher than the cutoff value for diagnosing nonanemic iron deficiency, we suggest that it will not be a good biomarkers in these cases. Our secondary outcomes showed that dietary supplements used during active infection such as vitamin C, D, lactoferrin and zinc might have a preventive value on postcovid hair loss, while azithromycin and ivermectin could have a negative long term effect on telogen effluvium.


Assuntos
Biomarcadores , COVID-19 , Suplementos Nutricionais , Ferritinas , Humanos , Ferritinas/sangue , COVID-19/sangue , COVID-19/diagnóstico , Biomarcadores/sangue , Feminino , Adulto , Masculino , Estudos de Casos e Controles , Pessoa de Meia-Idade , SARS-CoV-2 , Azitromicina/uso terapêutico , Ivermectina/uso terapêutico , Alopecia/diagnóstico , Alopecia/sangue , Alopecia/etiologia , Cabelo , Adulto Jovem
9.
Sci Rep ; 14(1): 13436, 2024 06 11.
Artigo em Inglês | MEDLINE | ID: mdl-38862721

RESUMO

Cartilage-hair hypoplasia syndrome (CHH) is an autosomal recessive disorder frequently linked to n.72A>G (previously known as n.70A>G and n.71A>G), the most common RMRP variant worldwide. More than 130 pathogenic variants in this gene have already been described associated with CHH, and founder alterations were reported in the Finnish and Japanese populations. Our previous study in Brazilian CHH patients showed a high prevalence of n.197C>T variant (former n.195C>T and n.196C>T) when compared to other populations. The aim of this study was to investigate a possible founder effect of the n.197C>T variant in the RMRP gene in a series of CHH Brazilian patients. We have selected four TAG SNPs within chromosome 9 and genotyped the probands and their parents (23 patients previously described and nine novel). A common haplotype to the n.197C>T variant carriers was identified. Patients were also characterized for 46 autosomal Ancestry Informative Markers (AIMs). European ancestry was the most prevalent (58%), followed by African (24%) and Native American (18%). Our results strengthen the hypothesis of a founder effect for the n.197C>T variant in Brazil and indicate that this variant in the RMRP gene originated from a single event on chromosome 9 with a possible European origin.


Assuntos
Efeito Fundador , Cabelo , Doença de Hirschsprung , Osteocondrodisplasias , Polimorfismo de Nucleotídeo Único , Humanos , Brasil , Doença de Hirschsprung/genética , Masculino , Osteocondrodisplasias/genética , Osteocondrodisplasias/congênito , Feminino , Cabelo/anormalidades , RNA Longo não Codificante/genética , Haplótipos , Doenças da Imunodeficiência Primária/genética , Hipotricose/genética , Cromossomos Humanos Par 9/genética , Criança
10.
Arch Dermatol Res ; 316(6): 318, 2024 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-38822862

RESUMO

BACKGROUND: One common problem in various patient groups is excessive hair loss on the head. One such group is people struggling with hypothyroidism. The market for preparations for hair growth and hair loss prevention includes betulin. PURPOSE: This pilot study investigated its effect on hair loss in hypothyroid patients. STUDY DESIGN: The study included a group of hypothyroid patients and a control group of people without hypothyroidism. Participants were randomly divided into a group taking placebo and betulin. METHODS: Results were investigated using photographic assessment of hair, trichoscopy and subjective evaluation of participants. CONCLUSION: The study did not conclusively prove that betulin would contribute to the inhibition of hair loss or regrowth.


Assuntos
Cabelo , Hipotireoidismo , Triterpenos , Humanos , Projetos Piloto , Triterpenos/administração & dosagem , Triterpenos/farmacologia , Feminino , Adulto , Hipotireoidismo/tratamento farmacológico , Cabelo/crescimento & desenvolvimento , Cabelo/efeitos dos fármacos , Pessoa de Meia-Idade , Masculino , Alopecia/tratamento farmacológico , Óleos de Plantas/administração & dosagem , Resultado do Tratamento , Ácido Betulínico
11.
J Agric Food Chem ; 72(20): 11493-11502, 2024 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-38738816

RESUMO

Cacumen platycladi (CP) is a frequently used traditional Chinese medicine to treat hair loss. In this study, CP fermented by Lactiplantibacillus plantarum CCFM1348 increased the proliferation of human dermal papilla cells. In an in vivo assay, compared to nonfermented CP, postbiotics (fermented CP) and synbiotics (live bacteria with nonfermented CP) promoted hair growth in mice. The Wnt/ß-catenin signaling pathway plays crucial roles in the development of hair follicles, including growth cycle restart and maintenance. Both postbiotics and synbiotics upregulated ß-catenin, a major factor of the Wnt/ß-catenin signaling pathway. Postbiotics and synbiotics also increased the vascular endothelial growth factor expression and decreased the BAX/Bcl2 ratio in the dorsal skin of mice. These results suggest that fermented CP by L. plantarum CCFM1348 may promote hair growth through regulating the Wnt/ß-catenin signaling pathway, promoting the expression of growth factors and reducing apoptosis.


Assuntos
Cabelo , Via de Sinalização Wnt , Animais , Camundongos , Cabelo/metabolismo , Cabelo/crescimento & desenvolvimento , Cabelo/química , Humanos , Via de Sinalização Wnt/efeitos dos fármacos , Biotransformação , Fermentação , beta Catenina/metabolismo , beta Catenina/genética , Masculino , Extratos Vegetais/metabolismo , Extratos Vegetais/farmacologia , Extratos Vegetais/química , Folículo Piloso/metabolismo , Folículo Piloso/crescimento & desenvolvimento , Proliferação de Células/efeitos dos fármacos , Apoptose/efeitos dos fármacos , Lactobacillus plantarum/metabolismo , Lactobacillus plantarum/crescimento & desenvolvimento
12.
Nano Lett ; 24(20): 6174-6182, 2024 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-38739468

RESUMO

Accumulated reactive oxygen species (ROS) and their resultant vascular dysfunction in androgenic alopecia (AGA) hinder hair follicle survival and cause permanent hair loss. However, safe and effective strategies to rescue hair follicle viability to enhance AGA therapeutic efficiency remain challenging. Herein, we fabricated a quercetin-encapsulated (Que) and polydopamine-integrated (PDA@QLipo) nanosystem that can reshape the perifollicular microenvironment to initial hair follicle regeneration for AGA treatment. Both the ROS scavenging and angiogenesis promotion abilities of PDA@QLipo were demonstrated. In vivo assays revealed that PDA@QLipo administrated with roller-microneedles successfully rejuvenated the "poor" perifollicular microenvironment, thereby promoting cell proliferation, accelerating hair follicle renewal, and facilitating hair follicle recovery. Moreover, PDA@QLipo achieved a higher hair regeneration coverage of 92.5% in the AGA mouse model than minoxidil (87.8%), even when dosed less frequently. The nanosystem creates a regenerative microenvironment by scavenging ROS and augmenting neovascularity for hair regrowth, presenting a promising approach for AGA clinical treatment.


Assuntos
Alopecia , Folículo Piloso , Indóis , Polímeros , Quercetina , Espécies Reativas de Oxigênio , Alopecia/tratamento farmacológico , Alopecia/patologia , Quercetina/farmacologia , Quercetina/administração & dosagem , Quercetina/química , Animais , Indóis/química , Indóis/farmacologia , Folículo Piloso/efeitos dos fármacos , Folículo Piloso/crescimento & desenvolvimento , Polímeros/química , Camundongos , Espécies Reativas de Oxigênio/metabolismo , Regeneração/efeitos dos fármacos , Humanos , Cabelo/efeitos dos fármacos , Cabelo/crescimento & desenvolvimento , Proliferação de Células/efeitos dos fármacos , Microambiente Celular/efeitos dos fármacos , Modelos Animais de Doenças , Masculino
13.
BMC Genomics ; 25(1): 498, 2024 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-38773419

RESUMO

BACKGROUND: The hair follicle development process is regulated by sophisticated genes and signaling networks, and the hair grows from the hair follicle. The Tianzhu white yak population exhibits differences in hair length, especially on the forehead and shoulder region. However, the genetic mechanism is still unclear. Isoform sequencing (Iso-seq) technology with advantages in long reads sequencing. Hence, we combined the Iso-seq and RNA-seq methods to investigate the transcript complexity and difference between long-haired yak (LHY) and normal-haired yak (NHY). RESULTS: The hair length measurement result showed a significant difference between LHY and NHY on the forehead and the shoulder (P-value < 0.001). The skin samples from the forehead and the shoulder of LHY and NHY were pooled for isoform sequencing (Iso-seq). We obtained numerous long transcripts, including novel isoforms, long non-coding RNA, alternative splicing events, and alternative polyadenylation events. Combined with RNA-seq data, we performed differential isoforms (DEIs) analysis between LHY and NHY. We found that some hair follicle and skin development-related DEIs, like BMP4, KRT2, IGF2R, and COL1A2 in the forehead skin; BMP1, KRT1, FGF5, COL2A1, and IGFBP5 in the shoulder skin. Enrichment analysis revealed that DEIs in both two comparable groups significantly participated in skin and hair follicle development-related pathways, like ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathways. The results indicated that the hair follicle development of Tianzhu white yak may influence the hair length difference. Besides, the protein-protein interaction (PPI) network of DEIs showed COL2A1 and COL3A1 exhibited a high degree of centrality, and these two genes were suggested as potential candidates for the hair length growth of Tianzhu white yak. CONCLUSIONS: The results provided a comprehensive analysis of the transcriptome complexity and identified differential transcripts that enhance our understanding of the molecular mechanisms underlying the variation in hair length growth in Tianzhu white yak.


Assuntos
Cabelo , Isoformas de Proteínas , RNA-Seq , Pele , Transcriptoma , Animais , Bovinos/genética , Pele/metabolismo , Cabelo/metabolismo , Cabelo/crescimento & desenvolvimento , Isoformas de Proteínas/genética , Isoformas de Proteínas/metabolismo , Folículo Piloso/metabolismo , Folículo Piloso/crescimento & desenvolvimento , Perfilação da Expressão Gênica , Processamento Alternativo , Análise de Sequência de RNA
14.
Nutrients ; 16(10)2024 May 20.
Artigo em Inglês | MEDLINE | ID: mdl-38794776

RESUMO

BACKGROUND: Functional Gastrointestinal Disorders (FGIDs) present a higher prevalence in individuals with Neurodevelopmental Disorders (NDDs). The Stress System and the Gut-Brain axis (GBA) may mediate these relations. We aimed to assess the prevalence and profile of FGIDs in a clinical sample of children with Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD) compared to typically developing children (TD) as well as to investigate possible relations between stress-related biomarkers and internalizing/externalizing problems in children with NDDS. METHODS: In total, 120 children, aged between 4 and 12 years old, formed three groups (N = 40, each): ADHD, ASD and TD. Salivary cortisol, hair cortisol and serum leptin were measured. RESULTS: The ASD group had more FGID problems than the TD group (p = 0.001). The ADHD and ASD groups had higher total internalizing/externalizing problems than the TD group (p < 0.0001, p < 0.0001, p = 0.005, respectively). Children with FGIDs showed more total, internalizing and externalizing problems compared to children without FGIDs (p < 0.0001, p < 0.0001, p = 0.041, respectively). The ADHD group showed lower AUCg values (p < 0.0001), while the hair cortisol was higher for the TD group (p < 0.0001). CONCLUSION: In conclusion, children with NDDs had more FGID symptoms and present higher internalizing and externalizing problems. Children with ADHD and FGIDs had more internalizing problems compared to those without FGIDs. No differences in stress-related biomarkers were shown to differentiate children with NDDs with and without FGIDs. Future prospective studies including a greater number of children may elucidate the biological pathways linking these comorbidities.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Transtorno do Espectro Autista , Gastroenteropatias , Cabelo , Hidrocortisona , Leptina , Saliva , Humanos , Criança , Hidrocortisona/sangue , Hidrocortisona/análise , Hidrocortisona/metabolismo , Cabelo/química , Transtorno do Deficit de Atenção com Hiperatividade/sangue , Leptina/sangue , Leptina/análise , Leptina/metabolismo , Feminino , Masculino , Saliva/química , Pré-Escolar , Gastroenteropatias/sangue , Gastroenteropatias/psicologia , Gastroenteropatias/epidemiologia , Transtorno do Espectro Autista/sangue , Transtorno do Espectro Autista/psicologia , Transtorno do Espectro Autista/metabolismo , Biomarcadores/sangue , Prevalência
16.
Environ Health Perspect ; 132(5): 57010, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38780454

RESUMO

BACKGROUND: Manganese (Mn) plays a significant role in both human health and global industries. Epidemiological studies of exposed populations demonstrate a dose-dependent association between Mn and neuromotor effects ranging from subclinical effects to a clinically defined syndrome. However, little is known about the relationship between early life Mn biomarkers and adolescent postural balance. OBJECTIVES: This study investigated the associations between childhood and adolescent Mn biomarkers and adolescent postural balance in participants from the longitudinal Marietta Communities Actively Researching Exposures Study (CARES) cohort. METHODS: Participants were recruited into CARES when they were 7-9 y old, and reenrolled at 13-18 years of age. At both time points, participants provided samples of blood, hair, and toenails that were analyzed for blood Mn and lead (Pb), serum cotinine, hair Mn, and toenail Mn. In adolescence, participants completed a postural balance assessment. Greater sway indicates postural instability (harmful effect), whereas lesser sway indicates postural stability (beneficial effect). Multivariable linear regression models were conducted to investigate the associations between childhood and adolescent Mn biomarkers and adolescent postural balance adjusted for age, sex, height-weight ratio, parent/caregiver intelligence quotient, socioeconomic status, blood Pb, and serum cotinine. RESULTS: CARES participants who completed the adolescent postural balance assessment (n=123) were 98% White and 54% female and had a mean age of 16 y (range: 13-18 y). In both childhood and adolescence, higher Mn biomarker concentrations were significantly associated with greater adolescent sway measures. Supplemental analyses revealed sex-specific associations; higher childhood Mn biomarker concentrations were significantly associated with greater sway in females compared with males. DISCUSSION: This study found childhood and adolescent Mn biomarkers were associated with subclinical neuromotor effects in adolescence. This study demonstrates postural balance as a sensitive measure to assess the association between Mn biomarkers and neuromotor function. https://doi.org/10.1289/EHP13381.


Assuntos
Biomarcadores , Cabelo , Manganês , Unhas , Equilíbrio Postural , Humanos , Adolescente , Biomarcadores/sangue , Manganês/sangue , Manganês/análise , Feminino , Masculino , Criança , Equilíbrio Postural/fisiologia , Cabelo/química , Unhas/química , Estudos de Coortes , Exposição Ambiental/estatística & dados numéricos , Chumbo/sangue , Estudos Longitudinais , Cotinina/sangue , Poluentes Ambientais/sangue
17.
PLoS One ; 19(5): e0304356, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38781258

RESUMO

INTRODUCTION: Functional near-infrared spectroscopy (fNIRS) is a promising tool for studying brain activity, offering advantages such as portability and affordability. However, challenges in data collection persist due to factors like participant physiology, environmental light, and gross-motor movements, with limited literature on their impact on fNIRS signal quality. This study addresses four potentially influential factors-hair color, hair cleanliness, environmental light, and gross-motor movements-on fNIRS signal quality. Our aim is to raise awareness and offer insights for future fNIRS research. METHODS: Six participants (4 Females, 2 Males) took part in four different experiments investigating the effects of hair color, hair cleanliness, environmental light, and gross-motor movements on fNIRS signal quality. Participants in Experiment 1, categorized by hair color, completed a finger-tapping task in a between-subjects block design. Signal quality was compared between each hair color. Participants in Experiments 2 and 3 completed a finger-tapping task in a within-subjects block design, with signal quality being compared across hair cleanliness (i.e., five consecutive days without washing the hair) and environmental light (i.e., sunlight, artificial light, no light, etc.), respectively. Experiment 4 assessed three gross-motor movements (i.e., walking, turning and nodding the head) in a within-subjects block design. Motor movements were then compared to resting blocks. Signal quality was evaluated using Scalp Coupling Index (SCI) measurements. RESULTS: Lighter hair produced better signals than dark hair, while the impact of environmental light remains uncertain. Hair cleanliness showed no significant effects, but gross motor movements notably reduced signal quality. CONCLUSION: Our results suggest that hair color, environmental light, and gross-motor movements affect fNIRS signal quality while hair cleanliness does not. Nevertheless, future studies with larger sample sizes are warranted to fully understand these effects. To advance future research, comprehensive documentation of participant demographics and lab conditions, along with signal quality analyses, is essential.


Assuntos
Cor de Cabelo , Espectroscopia de Luz Próxima ao Infravermelho , Humanos , Feminino , Masculino , Espectroscopia de Luz Próxima ao Infravermelho/métodos , Adulto , Cor de Cabelo/fisiologia , Luz , Adulto Jovem , Cabelo/química , Cabelo/fisiologia , Movimento/fisiologia , Movimento (Física)
18.
Medicine (Baltimore) ; 103(21): e37247, 2024 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-38787970

RESUMO

RATIONALE: Cartilage-hair hypoplasia (CHH, OMIM # 250250) is a rare autosomal recessive disorder, which includes cartilage-hair hypoplasia-anauxetic dysplasia (CHH-AD) spectrum disorders. CHH-AD is caused by homozygous or compound heterozygous mutations in the RNA component of the mitochondrial RNA-processing Endoribonuclease (RMRP) gene. PATIENT CONCERNS: Here, we report 2 cases of Korean children with CHH-AD. DIAGNOSES: In the first case, the patient had metaphyseal dysplasia without hypotrichosis, diagnosed by whole exome sequencing (WES), and exhibited only skeletal dysplasia and lacked extraskeletal manifestations, such as hair hypoplasia and immunodeficiency. In the second case, the patient had skeletal dysplasia, hair hypoplasia, and immunodeficiency, which were identified by WES. INTERVENTIONS: The second case is the first CHH reported in Korea. The patients in both cases received regular immune and lung function checkups. OUTCOMES: Our cases suggest that children with extremely short stature from birth, with or without extraskeletal manifestations, should include CHH-AD as a differential diagnosis. LESSONS SUBSECTIONS: Clinical suspicion is the most important and RMRP sequencing should be considered for the diagnosis of CHH-AD.


Assuntos
Cabelo , Doença de Hirschsprung , Mutação , Osteocondrodisplasias , Humanos , República da Coreia , Osteocondrodisplasias/genética , Osteocondrodisplasias/diagnóstico , Masculino , Feminino , Cabelo/anormalidades , Doença de Hirschsprung/genética , Doença de Hirschsprung/diagnóstico , Nanismo/genética , Nanismo/diagnóstico , Doenças da Imunodeficiência Primária/genética , Doenças da Imunodeficiência Primária/diagnóstico , Hipotricose/genética , Hipotricose/diagnóstico , Sequenciamento do Exoma , Lactente , Pré-Escolar , Endorribonucleases/genética , Criança , RNA Longo não Codificante
19.
Ann Med ; 56(1): 2357738, 2024 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38819080

RESUMO

BACKGROUND: Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition. While inflammatory biomarkers are valuable for diagnosing and monitoring the disease, their correlation with patients' quality of life (QoL) is not well-established. PURPOSE: This study aims to investigate the correlations between inflammatory biomarkers and the quality of life (QoL) variables of individuals diagnosed with IBD in clinical remission. METHODS: The sample of this cross-sectional study included 74 patients (80% women; 45 ± 11 years old) diagnosed with IBD. Outcome variables included faecal calprotectin (FC), C-reactive protein (CRP), cortisol levels from hair samples, and anxiety and depression assessed using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D, respectively), alongside QoL evaluated with the Inflammatory Bowel Disease Questionnaire 32 (IBDQ-32). Bivariate correlations were calculated using the Pearson correlation coefficient, and stepwise linear regression analyses were conducted to identify independent factors contributing to IBDQ-32 scores. RESULTS: The IBDQ-32 did not significantly correlate with any biomarkers. However, it exhibited a large and statistically significant negative correlation with HADS-A (r = -0.651) and HADS-D (r = -0.611) scores (p < 0.001). Stepwise linear regression analyses indicated that HADS-A was a significant and independent predictor for IBDQ-32 scores (Adjusted R2 = 0.41, ß = -0.65, p < 0.001). CONCLUSIONS: Inflammatory markers such as CRP, FC, or cortisol in hair do not play a decisive role in assessing the QoL of IBD patients. These findings emphasize the significance of considering psychological factors in evaluating and managing QoL in IBD patients in order to identify severity, suggesting that instruments like HADS should be integral to comprehensive patient assessments.


Assuntos
Ansiedade , Biomarcadores , Proteína C-Reativa , Depressão , Fezes , Cabelo , Hidrocortisona , Doenças Inflamatórias Intestinais , Complexo Antígeno L1 Leucocitário , Qualidade de Vida , Humanos , Feminino , Estudos Transversais , Masculino , Pessoa de Meia-Idade , Biomarcadores/análise , Doenças Inflamatórias Intestinais/psicologia , Doenças Inflamatórias Intestinais/metabolismo , Adulto , Proteína C-Reativa/análise , Proteína C-Reativa/metabolismo , Complexo Antígeno L1 Leucocitário/análise , Hidrocortisona/metabolismo , Hidrocortisona/análise , Fezes/química , Ansiedade/diagnóstico , Ansiedade/psicologia , Cabelo/química , Depressão/diagnóstico , Depressão/psicologia , Inquéritos e Questionários
20.
Body Image ; 50: 101719, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38788592

RESUMO

Eurocentric physical characteristics, including a thin, tall physique, long straight hair, and fair skin, typify Western beauty standards. Past research indicates that for Black women, greater identification with one's racial/ethnic culture may buffer against internalizing Eurocentric beauty standards, specifically the thin ideal. Black/White Biracial women often experience different appearance pressures from each of their racial identity's sociocultural appearance ideals. Unfortunately, body image research is limited among Bi/Multiracial individuals. Participants were recruited online via Prime Panels, a high-quality data recruitment service provided by CloudResearch. Participants, M(SD)Age= 34.64 (12.85), self-reported their racial/ethnic identification, thin and thick/curvy ideal internalization, and hair and skin tone satisfaction. Using linear regression analyses, we assessed whether racial/ethnic identification buffered against monoracial Black (n = 317) and Black/White Biracial (n = 254) women's thin ideal internalization. Additionally, we assessed whether stronger racial/ethnic identity was associated with stronger thick/curvy ideal internalization and hair and skin tone satisfaction. Supporting hypotheses, greater racial/ethnic identification was associated with higher thick/curvy ideal internalization and hair and skin tone satisfaction among both Black and Biracial women. Contrary to hypotheses, greater racial/ethnic identification was not associated with lower thin ideal internalization in either group. Our results stress the need to use racially and culturally sensitive measurements of body image.


Assuntos
Imagem Corporal , Cabelo , Satisfação Pessoal , Pigmentação da Pele , População Branca , Humanos , Feminino , Adulto , Imagem Corporal/psicologia , População Branca/psicologia , Beleza , Identificação Social , Negro ou Afro-Americano/psicologia , Adulto Jovem , Pessoa de Meia-Idade , Autoimagem
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