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1.
Braz. j. biol ; 84: e257402, 2024. tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1355856

RESUMO

Abstract Visceral leishmaniasis (VL) is an infectious disease predominant in countries located in the tropics. The prediction of occurrence of infectious diseases through epidemiologic modeling has revealed to be an important tool in the understanding of its occurrence dynamic. The objective of this study was to develop a forecasting model for the incidence of VL in Maranhão using the Seasonal Autoregressive Integrated Moving Average model (SARIMA). We collected monthly data regarding VL cases from the National Disease Notification System (SINAN) corresponding to the period between 2001 and 2018. The Box-Jenkins method was applied in order to adjust a SARIMA prediction model for VL general incidence and by sex (male or female) for the period between January 2019 and December 2013. For 216 months of this time series, 10,431 cases of VL were notified in Maranhão, with an average of 579 cases per year. With regard to age range, there was a higher incidence among the pediatric public (0 to 14 years of age). There was a predominance in male cases, 6437 (61.71%). The Box-Pierce test figures for overall, male and female genders supported by the results of the Ljung-Box test suggest that the autocorrelations of residual values act as white noise. Regarding monthly occurrences in general and by gender, the SARIMA models (2,0,0) (2,0,0), (0,1,1) (0,1,1) and (0,1,1) (2, 0, 0) were the ones that mostly adjusted to the data respectively. The model SARIMA has proven to be an adequate tool for predicting and analyzing the trends in VL incidence in Maranhão. The time variation determination and its prediction are decisive in providing guidance in health measure intervention.


Resumo A leishmaniose visceral (LV) é uma doença de natureza infecciosa, predominante em países de zonas tropicais. A predição de ocorrência de doenças infecciosas através da modelagem epidemiológica tem se revelado uma importante ferramenta no entendimento de sua dinâmica de ocorrência. O objetivo deste estudo foi desenvolver um modelo de previsão da incidência da LV no Maranhão usando o modelo de Média Móvel Integrada Autocorrelacionada Sazonal (SARIMA). Foram coletados os dados mensais de casos de LV através do Sistema de Informação de Agravos de Notificação (SINAN) correspondentes ao período de 2001 a 2018. O método de Box-Jenkins foi aplicado para ajustar um modelo de predição SARIMA para incidência geral e por sexo (masculino e feminino) de LV para o período de janeiro de 2019 a dezembro de 2023. Durante o período de 216 meses dessa série temporal, foram registrados 10.431 casos de LV no Maranhão, com uma média de 579 casos por ano. Em relação à faixa etária, houve maior registro no público pediátrico (0 a 14 anos). Houve predominância do sexo masculino, com 6437 casos (61,71%). Os valores do teste de Box-Pierce para incidência geral, sexo masculino e feminino reforçados pelos resultados do teste Ljung-Box sugerem que as autocorrelações de resíduos apresentam um comportamento de ruído branco. Para incidência mensal geral e por sexo masculino e feminino, os modelos SARIMA (2,0,0) (2,0,0), (0,1,1) (0,1,1) e (0,1,1) (2, 0, 0) foram os que mais se ajustaram aos dados, respectivamente. O modelo SARIMA se mostrou uma ferramenta adequada de previsão e análise da tendência de incidência da LV no Maranhão. A determinação da variação temporal e sua predição são determinantes no norteamento de medidas de intervenção em saúde.


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Leishmaniose Visceral/diagnóstico , Leishmaniose Visceral/epidemiologia , Estações do Ano , Brasil/epidemiologia , Incidência , Modelos Estatísticos
2.
Food Chem ; 399: 134018, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36055069

RESUMO

Herein, a modified indirect method was established for the determination of 3-monochloropropane-1,2-diol esters (3-MCPDEs) and glycidyl esters (GEs), employing magnetic solid phase extraction by boronic acid-functionalized magnetic nanoparticles to replace the traditional clean-up procedure. Compared with routine methods, it has been proved to be more sensitive with limits of detection in the range of 0.02-1.5 µg/kg and less susceptible to contamination of phenylboronic acid derivatives and fatty acid methyl esters. The proposed method was applied to analyze 42 samples covering the entire infant formula (IF) production chain. Results revealed that homogenization process contributed 79-91 % of the total growth of the contaminants due to the vegetable oil addition, while the following evaporation and spray-drying processes contributed 9-21 % of the total growth owing to involved heat treatment. The GE levels in final IF products exceeded the maximum level set by EU regulation 2020/1322, indicating quality safety concerns in the production chain.


Assuntos
Ésteres , alfa-Cloridrina , Ésteres/análise , Ácidos Graxos/análise , Contaminação de Alimentos/análise , Humanos , Lactente , Fórmulas Infantis/análise , Fenômenos Magnéticos , Extração em Fase Sólida , alfa-Cloridrina/análogos & derivados , alfa-Cloridrina/análise
4.
J Exp Child Psychol ; 225: 105493, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36007352

RESUMO

Restrictions in the sequencing of sounds (phonotactic constraints) can be represented at the level of sound co-occurrences (e.g., in baF.Pev, F and P co-occur) and at the level of the syllable (e.g., F is syllable-coda/end, P is syllable-onset/start). Can children (5-year-olds) and infants (11-month-olds) represent constraints as sound co-occurrences and/or relative to syllable positions? Participants listened to artificial languages displaying both word-medial consonant restrictions in co-occurrence pairs (e.g., FP or DZ but not FZ) and in the position of consonants within syllables (e.g., P/Z onsets and D/F codas) in words like baF.Pev and tiD.Zek. Children responded similarly to novel words with the same (e.g., FP) versus different (e.g., FZ) co-occurrence pairs, but they were more misled (i.e., responded "heard it before") by novel words with consonants in the same (e.g., onset-P) versus different (e.g., coda-P) syllable positions (Experiment 1). With the same training stimuli, infants had similar orientation times for novel words with the same versus different co-occurrence pairs, but they had longer orientation times for novel words with consonants in the same versus different syllable positions (Experiment 2). Thus, across different methods and ages, syllable-position information was more readily available for generalization than consonant co-occurrence information. The results suggest that when multiple regularities are present simultaneously, some phonotactic constraints (e.g., consonants in particular syllable positions) may be spontaneously represented and generalized by children and infants, whereas others (e.g., consonant co-occurrences) might not be available. The results contribute toward understanding how children and infants represent sound sequences.


Assuntos
Fonética , Percepção da Fala , Criança , Pré-Escolar , Generalização Psicológica , Humanos , Lactente , Idioma , Aprendizagem
5.
Parasitol Int ; 92: 102689, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36240994

RESUMO

This study aimed to estimate dynamic changes in seroprevalence of Toxoplasma gondii within the general population living in the northern part of the Republic of Serbia (Province of Vojvodina) during a 14-year period. The differences in prevalence of anti-toxoplasma antibodies were analyzed in correlation with age, gender, residential area (rural/urban) and meteorological factors. In this cohort retrospective study, 24,440 subjects between 1 and 88 years old were enrolled. To determine the presence of T. gondii-specific IgM and IgG antibodies in serum samples, commercially available ELISA kits were used (Euroimmun, Luebeck, Germany). During the study period, the overall T. gondii seroprevalence was 23.5%. The seroprevalence continuously decreased over time from 31.7% in 2008 to 20.4% in 2021 (0.81% per year, p < 0.001). Approximately 2% of patients had a serologic profile positive for both anti-Toxoplasma IgG and IgM antibodies. The seroprevalence was higher (28.87%) among men compared to women (24.28%), while urban residents (24.94%) had lower seroprevalence than the rural population (28.17%). A statistically significant negative correlation (r = -0.559) was found between serologic profile of patients positive for both T. gondii IgG and IgM antibodies and the annual mean air temperature. No significant association was observed between seropositivity to T. gondii infection and examined meteorological factors. These data could be useful to national and regional health authorities to create an optimal health policy to reduce rate of T. gondii infections.


Assuntos
Toxoplasma , Toxoplasmose , Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Estudos Soroepidemiológicos , Sérvia/epidemiologia , Iugoslávia , Estudos Retrospectivos , Anticorpos Antiprotozoários , Imunoglobulina G , Imunoglobulina M , Fatores de Risco
6.
J Exp Child Psychol ; 226: 105564, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36265238

RESUMO

In social groups, some individuals have more influence than others, for example, because they are learned from or because they coordinate collective actions. Identifying these influential individuals is crucial to learn about one's social environment. Here, we tested whether infants represent asymmetric social influence among individuals from observing the imitation of movements in the absence of any observable coercion or order. We defined social influence in terms of Granger causality; that is, if A influences B, then past behaviors of A contain information that predicts the behaviors and mental states of B above and beyond the information contained in the past behaviors and mental states of B alone. Infants (12-, 15-, and 18-month-olds) were familiarized with agents (imitators) influenced by the actions of another one (target). During the test, the infants observed either an imitator who was no longer influenced by the target (incongruent test) or the target who was not influenced by an imitator (neutral test). The participants looked significantly longer at the incongruent test than at the neutral test. This result shows that infants represent and generalize individuals' potential to influence others' actions and that they are sensitive to the asymmetric nature of social influence; upon learning that A influences B, they expect that the influence of A over B will remain stronger than the influence of B over A in a novel context. Because of the pervasiveness of social influence in many social interactions and relationships, its representation during infancy is fundamental to understand and predict others' behaviors.


Assuntos
Aprendizagem , Meio Social , Lactente , Humanos
7.
J Affect Disord ; 321: 16-27, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36272461

RESUMO

BACKGROUND: During the perinatal period, women's perceived quality of life (QOL) may be altered due to physiological, psychological, and bodily changes, as well as changes in family functioning. OBJECTIVES: to explore in a sample of women from the general population, the associations between physical and mental QOL at 1 year post-partum and i) pregnancy social support, demographic, socioeconomic, medical and child health-related factors, paternal and maternal psychological characteristics at 2 months and 1 year post-partum, ii) antenatal preventive measures (early prenatal interview/antenatal classes). METHODS: We used data from the "French Longitudinal Study since Childhood" (ELFE), a representative cohort of children and their parents followed from birth to adulthood. Data were collected from mothers in the maternity ward, at 2 months and 1-year post-partum. QOL was assessed using the SF12 physical (PCS-12) and mental (MCS-12) subscales. RESULTS: Women with both low PCS-12 and MCS-12 scores were more likely to have high maternal age and to experience psychological difficulties during pregnancy. They also had more frequent PNDS, quarrels with insults within the couple, low sleep time at 2 months postpartum, and more frequently received psychological, social and child caregiver support, and were more often housewives or students at 1-year post-partum. Others factors are specific for low PCS-12 or MCS-12. There was no association with antenatal preventive measure and QOL at 1-year post-partum. CONCLUSION: Factors influencing maternal QOL are multiple and multidimensional and can mostly be identified during the ante or early postnatal period. A graduated and coordinated preventive and curative pathway would improve women's health. An ecosystemic approach to pregnancy and the perinatal period could help preventing the negative effects of environment on mothers and thus infants during the "1000-day period".


Assuntos
Saúde Mental , Qualidade de Vida , Humanos , Lactente , Criança , Feminino , Gravidez , Adulto , Qualidade de Vida/psicologia , Estudos Longitudinais , Mães/psicologia , Parto
8.
J Affect Disord ; 321: 74-82, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36280196

RESUMO

OBJECTIVE: To examine the effects of prenatal maternal depression, anxiety and stress, and postnatal depression on infant early neurodevelopment, and the sex dimorphism. STUDY DESIGN: We used data from 3379 mother-infant pairs from the Shanghai Birth Cohort. Maternal mental health was assessed using the Center for Epidemiological Studies-Depression Scale, Zung Self-Rating Anxiety Scale, Perceived Stress Scale at mid-pregnancy, and the Edinburgh Postnatal Depression Scale at postpartum. Infant neurodevelopment was evaluated using the Ages & Stages Questionnaires and Bayley Scales at ages 6, 12, and 24 months, respectively. Linear mixed models and linear regression models were used. RESULTS: Among 3379 mothers, 11.07 %, 5.42 %, and 34.85 % of women experienced depression, anxiety, and elevated stress, separately. As maternal prenatal mental scores increased per 1SD, infant social-emotional scores decreased -2.82 (-3.86, -1.79) vs -2.86 (-3.94, -1.79) for depression, -2.34 (-3.38, -1.31) vs -2.72 (-3.81, -1.64) for anxiety, and -2.55 (-3.60, -1.50) vs -3.41 (-4.48, -2.35) for stress among boys and girls at age 24 months, respectively. Associations were also observed on social-emotional and communication scores in boys and girls, and fine motor in girls at age 6 and 12 months. These associations were not observed for postpartum depression. LIMITATION: Generalizability of the results to other population remains to be determined. CONCLUSIONS: Prenatal maternal depression, anxiety, and stress were negatively associated with infant early neurodevelopment, which were not observed for postpartum depression. We underscore the importance of maternal prenatal mental health in optimizing infant neuropsychiatric development.


Assuntos
Depressão Pós-Parto , Humanos , Gravidez , Lactente , Masculino , Feminino , Pré-Escolar , Depressão Pós-Parto/epidemiologia , Depressão Pós-Parto/psicologia , Depressão/epidemiologia , Depressão/psicologia , China/epidemiologia , Ansiedade/epidemiologia , Ansiedade/psicologia , Transtornos de Ansiedade/epidemiologia , Transtornos de Ansiedade/psicologia , Mães/psicologia
9.
J Exp Child Psychol ; 226: 105574, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36332434

RESUMO

Rewarding individuals who distribute resources fairly and punishing those who distribute resources unfairly may be very important actions for fostering cooperation. This study investigated whether 9-month-olds have some expectations concerning punishments and rewards that follow distributive actions. Infants were shown simple animations and were tested using the violation-of-expectation paradigm. In Experiment 1, we found that infants looked longer when they saw a bystander delivering a corporal punishment to a 'fair distributor,' who distributed some windfall resources equally to the possible recipients, rather than to an 'unfair distributor,' who distributed the resources unequally. This pattern of looking times was reversed when, in Experiment 2, punishments were replaced with rewards. These findings suggest an early emergence of expectations about punishing and rewarding actions in third-party contexts, and they help to evaluate competing claims about the origins of a sense of fairness.


Assuntos
Punição , Recompensa , Lactente , Humanos
10.
J Exp Child Psychol ; 226: 105569, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36332436

RESUMO

Joint Attention (JA) in parent-infant interaction has been demonstrated to contribute to infants' language outcomes. A limited number of studies have investigated the characteristics of JA episodes during parent-toddler interaction in relation to toddlers' language development. The majority of these studies were conducted with mothers, whereas JA with fathers remains understudied. The current study investigated JA episodes during interactions with mothers and fathers separately as well as longitudinal associations with child language outcomes. A total of 31 toddlers (18 girls) and their mothers and fathers participated in the study at ages 2 years (M = 24.07 months, SD = 1.45) and 3 years (M = 37.44 months, SD = 1.72). JA episodes were observed during free play interactions at age 2 and were coded microanalytically; receptive and expressive language skills were assessed by Bayley Scales of Infant and Toddler Development-Third Edition at ages 2 and 3. No significant differences in JA episodes were found between mother-toddler and father-toddler dyads. Whereas JA characteristics with mothers were not found to be significantly associated with toddlers' language outcomes, multiple linear regression analyses showed that paternal education and parent-followed JA episodes during father-toddler interaction at age 2 explained a significant amount of variance in toddlers' expressive language skills at age 3. Findings suggest that JA episodes during interactions with fathers might benefit toddlers' expressive language development.


Assuntos
Desenvolvimento da Linguagem , Idioma , Feminino , Lactente , Criança , Humanos , Pré-Escolar , Linguagem Infantil , Cognição , Atenção
11.
J Exp Child Psychol ; 226: 105577, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36335835

RESUMO

After decades of research suggesting that metacognition-that is, processes whereby people monitor and regulate their cognitive performance-did not emerge and is not related to children's performance until late childhood, recent studies have provided evidence that even preverbal infants can access their internal states. The existence of this basic metacognition raises the question of the variables influencing its development at such a young age and whether such early skills could predict successful cognitive performance. The current study had two main goals: (a) exploring the relation between parental metacognitive style and children's early metacognition and (b) determining whether these early metacognitive skills can predict children's memory performance. To this end, 2.5- to 4.5-year-old children (N = 72) and their parents were recruited. To assess parental metacognitive style, parent-child dyads were invited to participate in a 15-min session during which they played memory games. The parents' speech during this session was later coded for metacognitive content. Children's memory was assessed using cued recall and recognition tests. During one of these recognition tests, participants had the opportunity to ask for a cue to help them decide whether their response was correct (i.e., metacognitive measure). Results revealed that parental metacognitive style predicted both children's metacognitive accuracy and memory performance. Interestingly, a mediation effect of children's metacognitive skills on the relation between parental style and memory performance was found. These findings suggest that environmental factors such as parental metacognitive style are related to children's early metacognition, which in turn is linked to children's memory development.


Assuntos
Metacognição , Criança , Lactente , Humanos , Pré-Escolar , Pais , Relações Pais-Filho , Cognição , Sinais (Psicologia)
12.
Immunol Allergy Clin North Am ; 43(1): 117-132, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36410998

RESUMO

The safe management of allergic skin disorders during pregnancy is essential to maternal and fetal health. Poorly controlled allergic skin disease affects the health of mother and child. This article reviews the disease course and treatment of atopic dermatitis, chronic urticaria, and allergic contact dermatitis in pregnancy. It focuses on topical and systemic therapies in the context of pregnancy and breastfeeding. Because disease activity may vary in pregnancy, prescription stewardship is imperative; a balance among disease control, minimum effective dosing, and medication safety profiles should be maintained. Secondary complications and risks to maternal or infant health should also be avoided.


Assuntos
Dermatite Alérgica de Contato , Dermatite Atópica , Dermatopatias , Lactente , Gravidez , Feminino , Criança , Humanos , Pele , Dermatite Atópica/terapia , Dermatite Atópica/tratamento farmacológico , Aleitamento Materno
13.
Immunol Allergy Clin North Am ; 43(1): 65-85, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36411009

RESUMO

Asthma is one of the most common potentially serious medical problems to complicate pregnancy. Optimal management of asthma during pregnancy is thus important for both mother and baby. Treating asthmatic women requires understanding the effects of pregnancy on the course of asthma, and, conversely, the effects of asthma on pregnancy outcomes. Successful management also requires an understanding the barriers to asthma control in this population of patients. Evidence has shown that it is essential that the allergist-immunologist, obstetrician, and patient work as a team during pregnancy to achieve optimal maternal and neonatal outcomes.


Assuntos
Asma , Doença Enxerto-Hospedeiro , Lactente , Recém-Nascido , Gravidez , Humanos , Feminino , Alergistas , Asma/diagnóstico , Asma/epidemiologia , Asma/terapia , Família
14.
J Exp Child Psychol ; 226: 105536, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36116316

RESUMO

The current study sought to tease apart the unique contributions of napping and nighttime sleep to infant learning, specifically in the context of motor problem solving. We challenged 54 walking infants to solve a novel locomotor problem at three time points-training, test, and follow-up the next morning. One group of infants napped during the delay between training and test. Another group did not sleep during the delay. A third group received the test immediately after training with no delay. Only the Nap group's strategy choices continued to improve through the follow-up session, suggesting that daytime sleep has an active role in strengthening otherwise fragile memory. Although group did not affect strategy maintenance, walk experience did, suggesting that task difficulty may shape the impact of sleep on learning. Thus, day sleep and night sleep make independent contributions to the consolidation of motor problem-solving strategies during infancy.


Assuntos
Aprendizagem , Sono , Lactente , Humanos , Resolução de Problemas , Caminhada
15.
Sci Total Environ ; 855: 158852, 2023 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-36122707

RESUMO

BACKGROUND: Few studies have investigated the adverse effects of preconception phthalate (PAE) exposure on birth weight in couples receiving assisted reproductive technology (ART) compared to naturally conceived newborns. OBJECTIVES: We examined the association between parental preconception/prenatal urinary phthalate exposure and low birth weight (LBW) risk in couples who conceived using ART or naturally. METHODS: From the Jiangsu Birth Cohort Study (China), we recruited 544 couples who conceived after infertility treatment and 940 couples who conceived naturally and gave birth to a singleton infant between November 2014 and December 2019. Seventeen metabolites of phthalate and three metabolites of phthalate alternatives were analyzed in parental spot urine samples. Clinical data were collected from medical records. We used generalized linear models, elastic net regression, Bayesian kernel machine regression, and quantile-based g-computation to examine the individual and joint effects of parental phthalate exposure on birth weight and LBW risk ratios (RR). RESULTS: The relationship between parental phthalate exposure and birth weight was consistent between ART and natural conception. Maternal exposure to mono-ethyl phthalate and mono-carboxyisooctyl phthalate was associated with an increased risk of LBW in ART-conceived infants (RR = 1.27; 95 % confidence interval (CI): 1.03, 1.56; and RR = 1.31; 95 % CI: 1.03, 1.67, respectively). In contrast, in the spontaneously conceived infants, higher paternal prenatal concentrations of mono-benzyl phthalate and mono-carboxyisononyl phthalate were associated with a 40 % and 53 % increase in LBW risk, respectively. Exposure to PAE mixtures was associated with LBW in ART-conceived infants, with the effects primarily driven by di-ethyl phthalate, benzylbutyl phthalate, and di-isononyl phthalate metabolites. Sex-specific LBW was observed, with females appearing to be more susceptible than males. CONCLUSIONS: Maternal preconception and paternal prenatal exposure to phthalates were associated with increased risk of LBW in infants. Compared with natural conception, ART-conceived fetuses were more sensitive to PAE mixtures, which requires further attention.


Assuntos
Coorte de Nascimento , Ácidos Ftálicos , Humanos , Recém-Nascido , Gravidez , Masculino , Lactente , Feminino , Peso ao Nascer , Estudos Prospectivos , Estudos de Coortes , Teorema de Bayes , Ácidos Ftálicos/urina , Recém-Nascido de Baixo Peso , Técnicas de Reprodução Assistida
16.
J Exp Child Psychol ; 226: 105554, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36208491

RESUMO

From 10 months of age, human infants start to understand the function of the eyes in the looking behavior of others to the point where they preferentially orient toward an object if the social partner has open eyes rather than closed eyes. Thus far, gaze following has been investigated in controlled laboratory paradigms. The current study investigated this early ability using a remote live testing procedure, testing infants in their everyday environment while manipulating whether the experimenter could or could not see some target objects. A total of 32 11- and 12-month-old infants' looking behavior was assessed, varying the experimenter's eye status condition (open eyes vs closed eyes) in a between-participant design. Results showed that infants followed the gaze of a virtual social partner and that they preferentially followed open eyes rather than closed eyes. These data generalize past laboratory findings to a noisier home environment and demonstrate gaze processing capacities of infants to a virtual partner interacting with the participants in a live setup.


Assuntos
Atenção , Comportamento do Lactente , Lactente , Humanos , Fixação Ocular
17.
Int J Cancer ; 152(2): 259-266, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-35913764

RESUMO

Anti-GD2 monoclonal antibodies (mAb) improve the prognosis of high-risk neuroblastoma (HR-NB). Worldwide experience almost exclusively involves toddlers and older patients treated after multimodality or second-line therapies, that is, many months postdiagnosis. In contrast, at our center, infants received anti-GD2 mAbs because this immunotherapy started during or immediately after induction chemotherapy. We now report on the feasibility, safety, and long-term survival in this vulnerable age group. Thirty-three HR-NB patients were <19 months old when started on 3F8 (murine mAb; n = 21) or naxitamab (humanized-3F8; n = 12), with 30″ to 90″ intravenous infusions. Patients received analgesics and antihistamines. Common toxicities (pain, urticaria, cough) were manageable, allowing outpatient treatment. Capillary leak, posterior reversible encephalopathy syndrome, and mAb-related long-term toxicities did not occur. Two 3F8 cycles were aborted due to bradycardia (a preexisting condition) and asthmatic symptoms, respectively. One patient received ½ dose of Day 1 naxitamab because of hypotension; full doses were subsequently administered. Post-mAb treatments included chemotherapy, radiotherapy, and anti-NB vaccine. Among 3F8 patients, 17/21 are in complete remission off all treatment at 5.6+ to 24.1+ (median 13.4+) years from diagnosis. Among naxitamab patients, 10/12 remain relapse-free post-mAb at 1.7+ to 4.3+ (median 3.1+) years from diagnosis. Toxicity was similar with short outpatient infusions and matched that observed with these and other anti-GD2 mAbs in older patients. These findings were reassuring given that naxitamab is dosed >2.5× higher (~270 mg/m2 /cycle) than 3F8, dinutuximab, and dinutuximab beta (70-100 mg/m2 /cycle). HR-NB in infants proved to be highly curable.


Assuntos
Antineoplásicos , Neuroblastoma , Síndrome da Leucoencefalopatia Posterior , Humanos , Lactente , Camundongos , Animais , Idoso , Síndrome da Leucoencefalopatia Posterior/induzido quimicamente , Síndrome da Leucoencefalopatia Posterior/tratamento farmacológico , Recidiva Local de Neoplasia/tratamento farmacológico , Anticorpos Monoclonais/efeitos adversos , Neuroblastoma/tratamento farmacológico , Imunoterapia , Fatores Imunológicos/uso terapêutico , Antineoplásicos/uso terapêutico
18.
Pediatr Clin North Am ; 70(1): 43-51, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36402470

RESUMO

Pediatrics is a specialty that is grounded in advocacy, possibly more than any other field of medicine. Infants, children, and adolescents depend on others to cover their basic needs including food, shelter, and education and rely on proxy voices to speak out on their behalf. In this article, we describe the importance of community advocacy in pediatrics, best practices for training pediatricians in community advocacy, and case studies to highlight trainee experiences and demonstrate how community advocacy and community-based participatory research can be incorporated in the career of a pediatrician.


Assuntos
Defesa da Criança e do Adolescente , Pediatria , Adolescente , Lactente , Criança , Humanos , Defesa da Criança e do Adolescente/educação , Pediatras
19.
J Nurs Care Qual ; 38(1): E9-E15, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36066846

RESUMO

BACKGROUND: Nonpharmacological interventions are needed to reduce pain during vaccine administration in infants. PURPOSE: To determine the effect of the Buzzy device, which is a combination of cold and vibration, on pain during measles-mumps-rubella (MMR) vaccine administration in 12-month-old infants. METHODS: A prospective randomized controlled experimental research design was used. RESULTS: A total of 60 infants were included in the study. During and after vaccine injection, pain scores of infants who had the Buzzy device were significantly lower than those of infants in the control group ( P = .001). CONCLUSIONS: Buzzy application may be an effective method in reducing pain during MMR vaccine administration. Use of the device is recommended for infants receiving vaccinations.


Assuntos
Vacina contra Sarampo-Caxumba-Rubéola , Dor , Lactente , Humanos , Estudos Prospectivos , Vacina contra Sarampo-Caxumba-Rubéola/efeitos adversos , Injeções , Dor/etiologia , Dor/prevenção & controle , Vacinação/efeitos adversos
20.
J Hazard Mater ; 443(Pt A): 130162, 2023 02 05.
Artigo em Inglês | MEDLINE | ID: mdl-36257112

RESUMO

Although drinking water is the main source of fluoride intake, recent studies reported that fluoride intake from foods could also be high, depending on cooking methods. In this study, we quantified the fluoride accumulation in foods soaked or boiled in fluoride-containing water and assessed the fluoride intake in different age groups from food and drinking water. We observed that, in the case of rice soaked in fluoride-containing water, more fluoride was accumulated in the rice than previously estimated. Fluoride interferes with the iodine staining process of rice, indicating fluoride adsorption. Fluoride accumulation in rice and vegetables increased when the soaking temperature was raised to 100 °C due to the gelatinization of rice grains and softening of vegetables. Ingesting foods boiled in fluoride-containing water increased the fluoride intake per body weight of infants more significantly than that in children and adults due to their low body weight. These results indicate that soaking and boiling foods in fluoride-containing water significantly increases fluoride intake compared to previous estimations. Therefore, it is necessary to re-evaluate the fluoride intake from food and drinking water considering the methods used for cooking food in each country and region.


Assuntos
Água Potável , Oryza , Criança , Lactente , Adulto , Humanos , Fluoretos , Adsorção , Verduras , Peso Corporal
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