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1.
Comput Math Methods Med ; 2022: 9234579, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35529271

RESUMO

The objective of this research is to analyze the quantitative evaluation of human small intestinal bleeding by observing and analyzing animal experiments of small intestinal hemorrhage in rabbit models for the convenience of understanding the role of energy spectrum CT iodine-water diagram in animal experimental research of quantitative evaluation of small intestinal bleeding in rabbit models. Compared with the energy spectrum of iodine-water graph of a rabbit CT model, the present study studied the quantitative evaluation of small intestinal bleeding by using a rabbit model instead of human. According to the method mentioned above and the analysis of experimental data, the role of energy spectrum CT iodine-water map and the quantitative evaluation of human small intestinal bleeding have been understood. It was found that the energy spectrum CT iodine-water map replaces humans in the rabbit model for quantitative evaluation of small intestinal bleeding in animal experiments, which is important in the present study. Besides, based upon the combination of theoretical and experimental data, the ten flow rates set on the base material iodine (water) maps of the arterial phase and the portal phase can be analyzed to detect the leakage of contrast agent. The yield was 100%. The research results showed that the animal experiment of quantitative assessment of small intestinal bleeding by replacing the human body with the rabbit model in the energy spectrum CT iodine-water diagram is critical to humans in the study of small intestinal hemorrhagic diseases. In addition, it can be used to adjust the treatment plan timely according to the amount of bleeding to prevent shock or heavy bleeding that threatens patients' lives.


Assuntos
Enteropatias , Iodo , Animais , Meios de Contraste , Hemorragia Gastrointestinal , Humanos , Enteropatias/diagnóstico por imagem , Coelhos , Tomografia Computadorizada por Raios X/métodos , Água
2.
Artigo em Alemão | MEDLINE | ID: mdl-35523165

RESUMO

OBJECTIVE: The use of the iodine-containing contrast agent diatrizoate was investigated in healthy rabbits and in rabbits with gastric dilatation and intestinal obstruction. For this purpose, transit times through the gastrointestinal tract and clinical use were investigated during a one year period. In addition, a possible influence on thyroid hormone levels was evaluated. MATERIAL AND METHODS: Transit times of contrast agent through the different intestinal sections were examined radiographically in 14 healthy rabbits. For this purpose, 7 ml/kg of a 300 mg iodine/ml and 600 mg diatrizoate/ml containing solution were administered. Radiographs were obtained at different time intervals. Three different doses (D1 2 ml/kg, D2 7 ml/kg, D3 10 ml/kg) were administered, and blood samples were collected at two time points (60 min, 24 h) to analyze thyroid hormone levels (TT4, fT4, TSH). In addition, 70 rabbits that had received the contrast agent diatrizoate because of gastric dilatation and suspected intestinal obstruction were retrospectively evaluated during a period of one year. Focus was placed on arrival of the contrast agent in the cecum, laboratory changes, and mortalities. RESULTS: In all healthy rabbits, contrast medium was detectable in the cecum after a mean of 45-60 min. In the animals suffering from gastrointestinal obstruction, this was delayed to a mean of 121.2 min. These animals showed hypothermia in 92.4 % and hyperglycemia in 45.9 %. 56.1 % exhibited an increase in urea and 33.9 % an increase in creatinine. In 71.4 % of cases, medical treatment was possible, however 12 % of these individuals succumbed to the disease. 28.6 % of the cases were managed surgically which was associated with a mortality of 50 %. TT4, fT4, and TSH levels displayed significant alterations among the three contrast agent doses (p < 0.05). These changes were found to be transient when follow-up was performed two weeks later. CONCLUSION AND CLINICAL RELEVANCE: When ileus is suspected in rabbits, diatrizoate may be helpful in evaluating the progression of the disease in addition to the use of native radiographs. Sufficient hydration and monitoring of renal function are advisable. Transient changes in thyroid hormones were evident but lacked clinical relevance.


Assuntos
Dilatação Gástrica , Obstrução Intestinal , Iodo , Animais , Meios de Contraste , Diatrizoato , Dilatação Gástrica/veterinária , Obstrução Intestinal/veterinária , Coelhos , Estudos Retrospectivos , Hormônios Tireóideos , Tireotropina
3.
Biointerphases ; 17(3): 031002, 2022 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-35513339

RESUMO

Here, we present a study on agarose thin-film samples that represent a model system for the exopolysaccharide matrix of biofilms. Povidone-iodide (PVP-I) was selected as an antibacterial agent to evaluate our x-ray photoelectron spectroscopy (XPS)-based methodology to trace specific marker elements, here iodine, commonly found in organic matrices of antibiotics. The in-depth distribution of iodine was determined by XPS analyses with variable excitation energies and in combination with argon gas cluster ion beam sputter cycles. On mixed agarose/PVP-I nanometer-thin films, both methods were found to solve the analytical task and deliver independently comparable results. In the mixed agarose/PVP-I thin film, we found the outermost surface layer depleted in iodine, whereas the iodine is homogeneously distributed in the depth region between this outermost surface layer and the interface between the thin film and the substrate. Depletion of iodine from the uppermost surface in the thin-film samples is assumed to be caused by ultrahigh vacuum exposure resulting in a loss of molecular iodine (I2) as reported earlier for other iodine-doped polymers.


Assuntos
Iodo , Povidona-Iodo , Argônio/química , Biofilmes , Iodetos , Espectroscopia Fotoeletrônica , Povidona , Sefarose
4.
Methods Mol Biol ; 2451: 621-630, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35505038

RESUMO

Antimicrobial photodynamic inactivation (aPDI) involves the use of a nontoxic dye or photosensitizer excited with visible light to produce reactive oxygen species that can kill all classes of microorganisms. Antimicrobial photodynamic therapy (aPDT) can be used in vivo as an alternative therapeutic strategy to treat localized infections due to its ability to selectively kill microbes while preserving host mammalian cells. aPDI can be potentiated by the addition of the nontoxic inorganic salt potassium iodide (KI). KI is an approved drug for antifungal therapy. The mechanism of potentiation with iodide is likely to be singlet oxygen addition to iodide to form iodine radicals, hydrogen peroxide, and molecular iodine. A previous chapter in this volume described potentiation of aPDI in vitro by addition of KI, while in this chapter we address the ability of KI to potentiate aPDT in vivo using an animal model of localized fungal infection. We employed oral candidiasis in immunosuppressed mice caused by a bioluminescent strain of Candida albicans and monitored by bioluminescence imaging.


Assuntos
Anti-Infecciosos , Iodo , Micoses , Fotoquimioterapia , Animais , Antibacterianos , Modelos Animais de Doenças , Iodetos , Mamíferos , Camundongos , Fotoquimioterapia/métodos , Iodeto de Potássio/farmacologia , Iodeto de Potássio/uso terapêutico
5.
Chem Soc Rev ; 51(8): 3243-3262, 2022 Apr 19.
Artigo em Inglês | MEDLINE | ID: mdl-35363235

RESUMO

Nuclear power will continue to provide energy for the foreseeable future, but it can pose significant challenges in terms of the disposal of waste and potential release of untreated radioactive substances. Iodine is a volatile product from uranium fission and is particularly problematic due to its solubility. Different isotopes of iodine present different issues for people and the environment. 129I has an extremely long half-life of 1.57 × 107 years and poses a long-term environmental risk due to bioaccumulation. In contrast, 131I has a shorter half-life of 8.02 days and poses a significant risk to human health. There is, therefore, an urgent need to develop secure, efficient and economic stores to capture and sequester ionic and neutral iodine residues. Metal-organic framework (MOF) materials are a new generation of solid sorbents that have wide potential applicability for gas adsorption and substrate binding, and recently there is emerging research on their use for the selective adsorptive removal of iodine. Herein, we review the state-of-the-art performance of MOFs for iodine adsorption and their host-guest chemistry. Various aspects are discussed, including establishing structure-property relationships between the functionality of the MOF host and iodine binding. The techniques and methodologies used for the characterisation of iodine adsorption and of iodine-loaded MOFs are also discussed together with strategies for designing new MOFs that show improved performance for iodine adsorption.


Assuntos
Iodo , Estruturas Metalorgânicas , Adsorção , Humanos , Íons , Estruturas Metalorgânicas/química
6.
J Environ Sci (China) ; 114: 412-421, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35459504

RESUMO

Marine aerosols play an important role in the global aerosol system. In polluted coastal regions, ultra-fine particles have been recognized to be related to iodine-containing species and is more serious due to the impact of atmospheric pollutants. Many previous studies have identified iodine pentoxide (I2O5, IP) to be the key species in new particles formation (NPF) in marine regions, but the role of IP in the polluted coastal atmosphere is far to be fully understood. Considering the high humidity and concentrations of pollutants in the polluted coastal regions, the gas-phase hydration of IP catalyzed by sulfuric acid (SA), nitric acid (NA), dimethylamine (DMA), and ammonia (A) have been investigated at DLPNO-CCSD(T)//ωB97X-D/aug-cc-pVTZ + aug-cc-pVTZ-PP with ECP28MDF (for iodine) level of theory. The results show that the hydration of IP involves a significant energy barrier of 22.33 kcal/mol, while the pollutants SA, NA, DMA, and A all could catalyze the hydration of IP. Especially, with SA and DMA as catalysts, the hydration reactions of IP present extremely low barriers and high rate constants. It is suggested that IP is unstable under the catalysis of SA and DMA to generate iodic acid, which is the key component in NPF in marine regions. Thus, the catalytic hydration of IP is very likely to trigger the formation of iodine-containing particles. Our research provides a clear picture of the catalytic hydration of IP as well as theoretical guidance for NPF in the polluted coastal atmosphere.


Assuntos
Poluentes Ambientais , Iodo , Aerossóis , Atmosfera , Catálise , Iodetos
7.
J Assoc Physicians India ; 70(4): 11-12, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35443323

RESUMO

The thyroid gland and it's function are both affected physiologically by pregnancy. During pregnancy, the thyroid gland expands by 10% in iodine-sufficient women and to a higher extent in iodine-deficient women. Anemia is a worldwide health problem affecting 33% of non-pregnant women and 38% of pregnant women. According to Western literature, the prevalence of hypothyroidism in pregnancy is roughly 2.5 percent. In India, there are few reports of prevalence of hypothyroidism during pregnancy, with prevalence rates ranging from 4.8 percent to 11 percent. Hypothyroidism was shown to be prevalent in 13.13 percent of pregnant women in Dhanwal et al study, with the majority of these hypothyroid pregnant women having subclinical hypothyroidism. There were only few studies in India regarding this, hence this study was carried out with objectives of 1) To assess the prevalence of thyroid diseases in pregnancy 2) To evaluate association between iron deficiency and thyroid disorders in early pregnancy. MATERIAL: This was across sectional study conductedbetween Jan 2017 to June 2019 at JSS Hospital, a tertiary care hospital in Mysuru.500 consecutive pregnant women aged 18-45 years in first trimester of pregnancy were recruited.Under all aseptic precautions, venous blood of about 5ml was drawn and sent for analysis of Hb, TSH, T3, T4, Anti TPO antibody and Serum Ferritin which were measured by chemiluminiscence method for all pregnant women. TSH value>2.5 but less than or equal to 10 with normal T4 were considered to have subclinical hypothyroidism, TSH value>10 irrespective of T4 values and TSH value >2.5 with low T4 values were considered to have overt Hypothyroidism(American Thyroid Association and National Guidelines). OBSERVATION: Out of 500 women, 9 were excluded because of pre analytical error, hence there were 491 pregnant women in the study. Among 491 pregnant women,156(31.77%) were hypothyroid and 7(1.42%) had thyrotoxicosis. Among 156 Hypothyroid women, 9(5.76%) had overt hypothyroidism and 147(94.23%) had subclinical hypothyroidism. Predominant symptom in Hypothyroid women was fatigue(35.6%) followed by hair loss(31.7%), cold intolerance(16.9%),dry skin(6.72%), constipation(2.65%), weight gain(2.24%) and poor memory(2.04%).Goitre was present in 10(6.41%) women. Among 491 pregnant women, 211(42.9%) had iron deficiency and 280(57%) had normal ferritin.Among 156 hypothyroid women,60 (38.46%) had low ferritin and 96(61.53%) had normal ferritin. Chi square analysis did not show any significant association between iron deficiency and hypothyroidism(p value of 0.168). CONCLUSION: The prevalence of hypothyroidism was very high in our setting compared to that seen in other published reports that is 31% of pregnant women. There was no association found between hypothyroidism and iron deficiency in this study.


Assuntos
Hipotireoidismo , Iodo , Complicações na Gravidez , Doenças da Glândula Tireoide , Feminino , Ferritinas , Hospitais , Humanos , Hipotireoidismo/diagnóstico , Hipotireoidismo/epidemiologia , Gravidez , Complicações na Gravidez/epidemiologia , Complicações na Gravidez/etiologia , Prevalência , Doenças da Glândula Tireoide/epidemiologia , Testes de Função Tireóidea , Tireotropina
8.
Radiat Prot Dosimetry ; 198(5): 281-289, 2022 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-35368083

RESUMO

This work investigates the impact of iodinated contrast medium (ICM) on radiation dose in computed tomography (CT) scans using linear models established through a phantom study. Thermoluminescence dosemeters (TLDs) were calibrated using semi-conductor X-ray dosemeters. An electron density phantom, with a vial containing TLDs and different concentrations of iodinated blood, were scanned at different tube voltages. Irradiated TLD outputs were measured and absorbed dose to iodinated blood calculated. CT numbers (tissue attenuation as measured by Hounsfield units) were plotted against absorbed doses to obtain linear models. Data from 49 real patient scans were used to validate the linear models. At each X-ray energy, CT numbers were linearly correlated with the absorbed doses, that is with the increase of blood iodine concentration, the CT number increased and the absorbed dose increased accordingly. ICM can cause an increase of organ dose; the average dose increases were 31.8 ± 8.9% for thyroid, 37.1 ± 9.2% for cardiac muscle, 77.7 ± 14.0% for cardiac chamber, 7.1 ± 2.3% for breast, 26.1 ± 7.3% for liver, 39.8 ± 11.8% for spleen, 96.3 ± 12.2% for renal cortex and 82.4 ± 11.6% for medulla nephrica. ICM used in enhanced CT scan resulted in increased organ doses. Our models for estimating organ dose based on CT number were established by experiment and verified in clinical use.


Assuntos
Meios de Contraste , Iodo , Humanos , Imagens de Fantasmas , Doses de Radiação , Tomografia Computadorizada por Raios X/métodos
9.
Int J Mol Sci ; 23(7)2022 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-35408964

RESUMO

Reactions of N'N'-bis(3-pyridylmethyl)oxalamide (L1), N'N'-bis(4-pyridylmethyl)oxalamide (L2), or N,N'-bis(3-pyridylmethyl)adipoamide) (L3) with angular dicarboxylic acids and Ni(II) salts under hydro(solvo)thermal conditions afforded a series of coordination polymers: {[Ni(L1)(OBA)(H2O)]·H2O}n (H2OBA = 4,4-oxydibenzoic acid), 1, {[Ni(L1)(SDA)(H2O)2]·H2O·CH3OH}n (H2SDA = 4,4-sulfonyldibenzoic acid), 2, {[Ni(L2)(OBA)]·C2H5OH}n, 3, {[Ni(L2)(OBA)]·CH3OH}n, 4, {[Ni2(L2)(SDA)2(H2O)3]·5H2O}n, 5, {[Ni2(L2)(SDA)2(H2O)3]·H2O·2C2H5OH}n, 6, {[Ni(L3)(OBA)(H2O)2]·2H2O}n, 7, {[Ni(L3)(SDA)(H2O)2]·2H2O}n, 8, and {[Ni(L3)0.5(SDA)(H2O)2]·0.5C2H5OH}n, 9, which have been structurally characterized by using single-crystal X-ray crystallography. Complex 1 exhibits an interdigitated 2D layer with the 2,4L2 topology and 2 is a 2D layer with the sql topology, while 3 and 4 are 3D frameworks resulting from polycatenated 2D nets with the sql topology and 5 and 6 are 2-fold interpenetrated 3D frameworks with the dia topology. Complexes 7 and 8 are 1D looped chains and 9 is a 2D layer with the 3,4L13 topology. The various structural types in 1-9 indicate that the structural diversity is subject to the flexibility and donor atom position of the neutral spacer ligands and the identity of the angular dicarboxylate ligands, while the role of the solvent is uncertain. The iodine adsorption of 1-9 was also investigated, demonstrating that that the flexibility of the spacer L1-L3 ligands can be an important factor that governs the feasibility of the iodine adsorption. Moreover, complex 9 shows a better iodine adsorption and encapsulates 166.55 mg g-1 iodine in the vapor phase at 60 °C, which corresponded to 0.38 molecules of iodine per formula unit.


Assuntos
Iodo , Níquel , Adsorção , Amidas , Ácidos Dicarboxílicos/química , Iodetos , Ligantes , Níquel/química , Polímeros/química
10.
Klin Monbl Augenheilkd ; 239(4): 593-596, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35472813

RESUMO

BACKGROUND: As studies have shown postsurgical polyvidone-iodine to be at least equal to postsurgical topical antibiotics, our postsurgical care regime was adjusted accordingly in 2017. Here, we retrospectively compared the postsurgical infection rate in patients who underwent strabismus surgery prior to and following this change in regimen in a routine clinical setting. PATIENTS AND METHODS: In this retrospective and explorative study, data from 162 adult patients who had undergone strabismus surgery was extracted from files: 98 patients who had received topical gentamycin in a combination ointment with steroid (postsurgery) followed by 1 week of topical gentamycin with nonsteroidal antiphlogistic eye drops for 1 week (group 1) and 64 who had received polyvidone-iodine once immediately postsurgically instead. We compared both groups' postsurgical healing period regarding occurrence of bacterial conjunctival infection and conjunctival swelling and redness as well as other complications. Data were extracted from the entries of the routine follow-up dates on postsurgical days 1, 7, and at 3 months. RESULTS: Mean age of group 1 was 49 years and 51 years in group 2. There was no significant difference between the kind of surgeries (recessions/resections) or the number of patients who had undergone a reoperation. There was no significant difference between the groups for any of the endpoints analyzed at any of the three regular follow-up dates. From group 1, 12.04% and from of group 2, 6.25% showed bacterial conjunctivitis 1 week postsurgery. There was no endophthalmitis. CONCLUSION: Topical polyvidone-iodine given once at the end of strabismus surgery is a good alternative to topical antibiotics with a comparable healing progress. It carries a comparable risk of infection as seen with a 1-week course of topical antibiotics. The advantages are less manipulation of the eye, no bacterial resistance caused, and cost efficiency. In addition, the lack of anti-inflammatories given in group 2 did not pose a disadvantage.


Assuntos
Iodo , Estrabismo , Adulto , Antibacterianos/uso terapêutico , Gentamicinas , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Estrabismo/tratamento farmacológico , Estrabismo/cirurgia
11.
Nutrients ; 14(8)2022 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-35458147

RESUMO

A universal salt iodization (USI) was introduced in Sarawak, Malaysia in 2008 to control the iodine deficiency disorders (IDD) among its population. The purpose of this study is to evaluate the impact of the USI among school children in Sarawak after 10 years of implementation. The data were extracted from 2008 and 2018 Sarawak state-wide IDD surveys. Briefly, both surveys were cross-sectional surveys covering information on the socio-demographic, status of goitre, urinary iodine, and the amount of iodine in the salt samples. A total of 1104 and 988 between the ages of 8 and 10 were involved in the 2008 and 2018 surveys, respectively. The overall prevalence of goitre among the school children in Sarawak was significantly lower in 2018 (0.1%) compared to 2008 (2.9%). The median urinary iodine concentration (UIC) in urine samples had risen significantly from 102.1 µg/L in 2008 to 126.0 µg/L in 2018. In terms of iodine content in salt samples, the median concentration improved significantly in 2018 (35.5 µg/L) compared to 2008 (14.7 µg/L). After 10 years of USI implementation in Sarawak, the results from both surveys confirmed the effectiveness of mandatory USI in increasing the nutritional iodine status of school children in Sarawak.


Assuntos
Bócio , Iodo , Criança , Bócio/epidemiologia , Humanos , Malásia/epidemiologia , Estado Nutricional , Prevalência , Cloreto de Sódio na Dieta
12.
Chem Commun (Camb) ; 58(32): 5013-5016, 2022 Apr 19.
Artigo em Inglês | MEDLINE | ID: mdl-35363232

RESUMO

Two amorphous metal-organic frameworks (aMOFs) were obtained from crystalline Co-MOF (SCNU-Z6) via temperature-induced (aT-SCNU-Z6) and water-immersed (aW-SCNU-Z6) approaches. They exhibited high iodine uptake, with the adsorption capacities of aT-SCNU-Z6 and aW-SCNU-Z6 reaching 2.05 and 5.04 g g-1, respectively. This work is the first report of iodine uptake by aMOFs.


Assuntos
Iodo , Estruturas Metalorgânicas , Adsorção , Iodetos , Estruturas Metalorgânicas/química , Água
13.
Chem Commun (Camb) ; 58(32): 4977-4980, 2022 Apr 19.
Artigo em Inglês | MEDLINE | ID: mdl-35403648

RESUMO

The interaction of a [bis(pyridine)iodine(I)]+ cation with a [bis(pyridine)silver(I)]+ cation, in which an iodonium ion acts as a nucleophile by transferring electron density to the silver(I) cation, is reinvestigated herein. No measurable interaction is observed between the cationic species in solution by NMR; DFT reveals that if there is an attractive interaction between these complexes in solution, it is dominantly the π-π interaction of pyridines.


Assuntos
Iodo , Cátions , Iodetos , Espectroscopia de Ressonância Magnética , Prata/química
14.
Nutrients ; 14(7)2022 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-35406006

RESUMO

Iodine deficiency is a common problem in pregnant women and may have implications for maternal and child health. Iodine supplementation during pregnancy has been recommended by several scientific societies. We undertook a cross-sectional survey to assess the efficacy of these recommendations in a European iodine-deficient region. Urinary iodine concentrations (UIC) were determined in pregnant women before (n = 203) and after (n = 136) the implementation of guidelines for iodine supplementation in pregnancy. Iodine supplementation (200 µg/day) reduced the proportion of pregnant women with severe iodine deficiency (37.4% to 18.0%, p = 0.0002). The median UIC increased from 67.6 µg/L to 106.8 µg/L but remained below the recommended target level (>150 µg/L) for pregnant women. In conclusion, iodine supplementation in pregnant women improved iodine status in this iodine-deficient region but was insufficient to achieve recommended iodine levels in pregnancy. Additional measures, such as the adjustment of the dose or timing of supplementation, or universal salt iodization, may be needed.


Assuntos
Iodo , Desnutrição , Complicações na Gravidez , Desnutrição Proteico-Calórica , Criança , Estudos Transversais , Suplementos Nutricionais , Feminino , Humanos , Iodetos , Estado Nutricional , Gravidez , Complicações na Gravidez/epidemiologia , Complicações na Gravidez/prevenção & controle , Cloreto de Sódio na Dieta
15.
Proc Natl Acad Sci U S A ; 119(17): e2119032119, 2022 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-35439051

RESUMO

SignificanceIodine-induced cleavage is widely used for detecting bacterial DNA phosphorothioation in gel electrophoresis, deep sequencing, and single-molecule optical mapping. However, we lack quantitative understanding of the phosphorothioate DNA (PT-DNA) cleavage efficiency and the chemoselectivity of this method for determination of phosphorothioate vs. phosphate. Computational explorations now reveal why iodine selectively attacks at sulfur in phosphorothioate links but not at normal phosphates. The active role of Tris buffer in the PT-DNA cleavage, and the factors controlling cleavage efficiency, were also revealed. Cleavage efficiency is limited by competition between the desired DNA backbone cleavage and unwanted P-S/P-O conversion. These mechanistic studies will guide the development of new methods for iodine-induced specific PT-DNA cleavage.


Assuntos
Iodo , Clivagem do DNA , DNA Bacteriano/genética , Iodetos , Fosfatos/química , Enxofre
16.
Inorg Chem ; 61(18): 7103-7110, 2022 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-35482439

RESUMO

Geometric analysis has been guiding the design and construction of metal-organic polyhedra. Here, a series of isohedral tetrahedra ZrIT-1 and -2 and VIT-1 and -2 were synthesized by a one-pot method relying on trivalent molecular building blocks. Structural analysis shows that the isohedral tetrahedra constructed with {V6(SO4)(CO2)3} have three different sets of prism lengths, while those constructed with {Zr3O(CO2)3} have two different sets of prism lengths. Comparison of two types of polyhedra reveals that the different sizes and coordination flexibilities of the two MBBs result in different cavity volumes. The environmentally toxic oxoanion trapping ability of ZrIT-1 was explored due to its structural stability and cation cage properties. The results show that ZrIT-1 can capture permanganate and dichromate anions in water with high efficiency and selectivity. Notably, the permanganate adsorption capacity can reach ∼276.6 mg/g, which exceeds those of most metal-organic framework materials. In addition, the adsorption and desorption of iodine showed that ZrIT-1 has a reversible adsorption capacity for iodine.


Assuntos
Iodo , Estruturas Metalorgânicas , Adsorção , Dióxido de Carbono , Iodetos , Estruturas Metalorgânicas/química , Metais
18.
J Org Chem ; 87(9): 6247-6262, 2022 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-35465667

RESUMO

A phenyliodine(III) diacetate-promoted/1,1,1,3,3,3-hexafluoroisopropanol-controlled dearomative spirocyclization of phenolic ketones was reported, providing two libraries of structurally interesting scaffolds, spirocyclohexadienonic ketals and their acetoxylated counterparts, in moderate to excellent yields under mild conditions. Control experiments unravel that the reaction proceeds through a spirocyclohexadienone-oxocarbenium cation species. In addition, an in situ-generated hypervalent iodine(III)-catalyzed version, as well as the late-stage transformation of products via conjugate additions, was also realized.


Assuntos
Iodo , Cetonas , Cátions , Fenóis
19.
Org Biomol Chem ; 20(18): 3721-3725, 2022 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-35442256

RESUMO

A series of 2,4-disubstituted 1,2,4-triazole-3-ones 4 were prepared via an iodine-DMSO-promoted three-component reaction of formaldehyde, amines and hydrazines in moderate yields.


Assuntos
Iodo , Aminas , Dimetil Sulfóxido , Hidrazinas , Iodetos , Estrutura Molecular
20.
Am J Case Rep ; 23: e935789, 2022 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-35477705

RESUMO

BACKGROUND The therapeutic approach to Graves' disease (GD) comprises thionamides, radioiodine ablation, or surgery as first-line therapy, and cholestyramine and oral iodine as second-line therapies. The role of lithium (Li) in GD as a primary or adjunctive therapy remains contentious. We present a case of GD managed by Li therapy with oral iodine solution. CASE REPORT A 26-year-old man, admitted with acute blast crisis secondary to chronic myeloid leukemia (CML), reported palpitations, 40-lb weight loss, heat intolerance, and fatigue. An examination revealed sinus tachycardia, elevated body temperature, and thyromegaly. Laboratory evaluation confirmed hyperthyroidism (TSH <0.005 mcIU/l, FT4 5.57 ng/dl, TT3 629 ng/dl) secondary to GD (TRAb >40 IU/l, TSIg 178%). Thionamides and surgery were contraindicated due to pancytopenia from a blast crisis. Inability to maintain post-radiation precautions precluded use of RAI. Cholestyramine was attempted and discontinued due to nausea. We introduced oral Li carbonate with oral iodine, which the patient tolerated. Thyroid functions improved with therapy (TSH 0.007 mcIU/l, FT4 0.82 ng/dl, TT3 122 ng/dl) with stable Li level (0.5-0.8 mmol/l). CONCLUSIONS Li inhibits iodine uptake through interference with sodium-iodide symporter and tyrosine iodination, thyroglobulin structure changes, peripheral deiodinase blockage, and preventing TSH and TSIg stimulation. Our case shows that a low therapeutic level of Li, in combination with oral iodine, can suppress thyroid overactivity without adverse effects. We suggest that low-dose Li carbonate is a safe and effective adjunctive antithyroid medication to be considered if primary therapies for hyperthyroidism are unavailable.


Assuntos
Doença de Graves , Hipertireoidismo , Iodo , Adulto , Crise Blástica , Carbonatos/uso terapêutico , Resina de Colestiramina/uso terapêutico , Doença de Graves/complicações , Doença de Graves/diagnóstico , Doença de Graves/tratamento farmacológico , Humanos , Hipertireoidismo/complicações , Hipertireoidismo/etiologia , Iodo/uso terapêutico , Radioisótopos do Iodo/uso terapêutico , Lítio/uso terapêutico , Masculino , Tireotropina
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