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1.
BMC Ophthalmol ; 24(1): 235, 2024 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-38840075

RESUMO

AIMS: To explore the application and long-term clinical effects of modified Yamane technique in intrascleral intraocular lens (IOL) fixation combined with or without iris reconstruction. SETTINGS AND DESIGN: The data of patients receiving IOL fixation with modified Yamane technique in an ophthalmology department between December 2021 and August 2023 were analyzed retrospectively. The longest follow-up duration was > 12 months. METHODS AND MATERIAL: The trailing haptic was fixed with the needle before the leading haptic. The silicone haptic stoppers were used to stabilize the IOL when iris reconstruction was combined. Preoperative and postoperative best-corrected visual acuity (BCVA), corneal endothelial cells (CECs), postoperative intraocular pressure (IOP), surgical indications and methods, and postoperative complications were recorded. Anterior segment optical coherence tomography (OCT) was used to evaluate IOL decentration and tilt. The paired sample t-test or Wilcoxon rank sum test were used to compare the results of the same index before and after the operation. RESULTS: Twelve patients (12 eyes) were included in this cohort. There were 1 case of IOL dislocation, eight cases of lens dislocation or subluxation, and three cases of aphakia. Traumatic lens dislocation was the main cause of aphakia. Primary lens extraction was performed in previous surgeries, and all three were combined with pars plana vitrectomy (PPV). Four of 12 patients underwent IOL fixation and iris reconstruction. The mean age of participants was 63 ± 10.61 years. The mean BCVA increased from 0.89 ± 0.72 logMAR to 0.39 ± 0.56 logMAR at the last visit (p < 0.05). The postoperative relative refractive error was - 0.13 ± 0.42 D (-0.60 D to + 0.57 D). The OCT showed that the IOLs were well centered, with a mean decentration of 0.20 ± 0.13 mm and a mean tilt of 2.31°±0.93°. Ten patients did not experience any complications. CONCLUSIONS: The modified Yamane technique in IOL fixation surgery, especially combined with iris reconstruction, reduces operation difficulty, increases operational stability and safety, and improves postoperative visual acuity without serious intra- or postoperative complications. The long-term improvement effect was remarkable.


Assuntos
Iris , Implante de Lente Intraocular , Lentes Intraoculares , Esclera , Acuidade Visual , Humanos , Feminino , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Implante de Lente Intraocular/métodos , Iris/cirurgia , Idoso , Acuidade Visual/fisiologia , Esclera/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Tomografia de Coerência Óptica/métodos , Seguimentos
2.
Nat Commun ; 15(1): 5048, 2024 Jun 13.
Artigo em Inglês | MEDLINE | ID: mdl-38871723

RESUMO

Despite the advent of genomic sequencing, molecular diagnosis remains unsolved in approximately half of patients with Mendelian disorders, largely due to unclarified functions of noncoding regions and the difficulty in identifying complex structural variations. In this study, we map a unique form of central iris hypoplasia in a large family to 6q15-q23.3 and 18p11.31-q12.1 using a genome-wide linkage scan. Long-read sequencing reveals a balanced translocation t(6;18)(q22.31;p11.22) with intergenic breakpoints. By performing Hi-C on induced pluripotent stem cells from a patient, we identify two chromatin topologically associating domains spanning across the breakpoints. These alterations lead the ectopic chromatin interactions between APCDD1 on chromosome 18 and enhancers on chromosome 6, resulting in upregulation of APCDD1. Notably, APCDD1 is specifically localized in the iris of human eyes. Our findings demonstrate that noncoding structural variations can lead to Mendelian diseases by disrupting the 3D genome structure and resulting in altered gene expression.


Assuntos
Cromatina , Iris , Linhagem , Translocação Genética , Humanos , Cromatina/metabolismo , Cromatina/genética , Iris/metabolismo , Masculino , Feminino , Cromossomos Humanos Par 6/genética , Cromossomos Humanos Par 18/genética , Células-Tronco Pluripotentes Induzidas/metabolismo , Adulto , Doenças da Íris/genética , Doenças da Íris/metabolismo , Doenças da Íris/patologia , Ligação Genética
3.
Comput Biol Med ; 177: 108631, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38824787

RESUMO

The incident light reflected from the cornea is rich in information about the human surroundings, and these reflected rays are imaged by the camera, which can be used for research on human consciousness and gaze analysis, and produce certain help in the fields of psychology, human computer interaction and disease diagnosis. However, limited by the low corneal reflection ability, when a high-definition camera captures corneal reflecting rays, a large amount of color and texture interference from the iris can seriously contaminate the corneal reflection images, resulting in low usability and ubiquity of corneal reflection images. In this paper, we propose a corneal reflection image extraction method with multiple eye images as input. We align the iris regions of multiple eye images with the help of iris localization method, and by comparing multiple iris regions, we obtain the complementary iris regions, so that the iris interference in the corneal reflection region can be stripped completely. A large number of experiments have demonstrated that our work can effectively mitigate iris interference and effectively improve the quality of corneal reflection images.


Assuntos
Córnea , Processamento de Imagem Assistida por Computador , Humanos , Córnea/diagnóstico por imagem , Processamento de Imagem Assistida por Computador/métodos , Iris/diagnóstico por imagem , Algoritmos
4.
Mol Genet Genomic Med ; 12(6): e2481, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38867642

RESUMO

PURPOSE: To characterize the phenotype and genotype of a Chinese family with autosomal-dominant retinitis pigmentosa (RP) accompanied by iris coloboma. METHODS: The proband, a 34-year-old male, was examined with his family by using fundus photography, optical coherence tomography (OCT), autofluorescence, and full-field electroretinography (ffERG). Genetic analyses were conducted through whole-exome sequencing (WES) to screen for variations. RESULTS: Three members of this Chinese family were shown to be bilateral iris coloboma. The male proband and his mother exhibited typical RP feature. The proband's late grandfather had been documented manifestation of iris coloboma. The mode of inheritance was confirmed to be autosomal dominance. Through linkage analysis and WES, a heterozygous variation in the miR-204 gene (n.37C>T), a noncoding RNA gene, was identified in these three members. CONCLUSIONS: In this third independent and the first Asian family, the existence of a miR-204 variant associated with RP accompanied by iris coloboma was confirmed. Our findings reinforce the significance of miR-204 as an important factor influencing visual function in the retina. When phenotypes like RP accompanied by iris coloboma in an autosomal-dominant pattern, including in Chinese patients, miR-204 aberrations should be considered.


Assuntos
Coloboma , MicroRNAs , Linhagem , Retinose Pigmentar , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Coloboma/genética , Coloboma/patologia , População do Leste Asiático , Iris/anormalidades , Iris/patologia , MicroRNAs/genética , Fenótipo , Retinose Pigmentar/genética
5.
Biomed Res Int ; 2024: 8112209, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38884018

RESUMO

Existing security issues like keys, pins, and passwords employed presently in almost all the fields that have certain limitations like passwords and pins can be easily forgotten; keys can be lost. To overcome such security issues, new biometric features have shown outstanding improvements in authentication systems as a result of significant developments in biological digital signal processing. Currently, the multimodal authentications have gained huge attention in biometric systems which can be either behavioural or physiological. A biometric system with multimodality club data from many biometric modalities increases each biometric system's performance and makes it more resistant to spoof attempts. Apart from electrocardiogram (ECG) and iris, there are a lot of other biometric traits that can be captured from the human body. They include face, fingerprint, gait, keystroke dynamics, voice, DNA, palm vein, and hand geometry recognition. Electrocardiograms (ECG) have recently been employed in unimodal and multimodal biometric recognition systems as a novel biometric technology. When compared to other biometric approaches, ECG has the intrinsic quality of a person's liveness, making it difficult to fake. Similarly, the iris also plays an important role in biometric authentication. Based on these assumptions, we present a multimodal biometric person authentication system. The projected method includes preprocessing, segmentation, feature extraction, feature fusion, and ensemble classifier where majority voting is presented to obtain the final outcome. The comparative analysis shows the overall performance as 96.55%, 96.2%, 96.2%, 96.5%, and 95.65% in terms of precision, F1-score, sensitivity, specificity, and accuracy.


Assuntos
Identificação Biométrica , Eletrocardiografia , Iris , Humanos , Eletrocardiografia/métodos , Identificação Biométrica/métodos , Iris/fisiologia , Iris/anatomia & histologia , Algoritmos , Biometria/métodos , Masculino , Feminino
6.
Expert Rev Med Devices ; 21(5): 439-446, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38803101

RESUMO

OBJECTIVES: Differentiation of iris and ciliary body lesions as benign or malignant and cystic or solid is important. The aim of this study was to compare anterior segment swept-source optical coherence tomography (AS SS-OCT) and ultrasound biomicroscopy (UBM) findings in iris and ciliary body tumors. RESEARCH DESIGN AND METHODS: Forty-two eyes of 38 cases with iris and ciliary body tumors imaged with UBM and AS SS-OCT between September 2018 and September 2023 were evaluated retrospectively. RESULTS: Of 42 eyes, 14 had melanoma, 14 iris pigment epithelial (IPE) cysts, 7 nevi, 3 Lisch nodules, 2 iris stromal cysts, 1 pars plana cysts, and 1 iris mammillations. An equivalent (100%) visualization of the anterior tumor margin was obtained with both techniques. Compared to AS SS-OCT, UBM was superior for posterior margin visualization in melanocytic tumors and IPE cysts. Bland-Altman plots demonstrated good agreement between UBM and AS SS-OCT for melanocytic tumors < 2.5 mm in base diameter and < 2 mm in thickness. CONCLUSIONS: Although, UBM is the gold standard for ciliary body and iridociliary tumors. AS SS-OCT should be considered as an excellent alternative to UBM, especially in minimally elevated iris lesions.


Assuntos
Corpo Ciliar , Microscopia Acústica , Tomografia de Coerência Óptica , Humanos , Tomografia de Coerência Óptica/métodos , Microscopia Acústica/métodos , Corpo Ciliar/diagnóstico por imagem , Corpo Ciliar/patologia , Masculino , Feminino , Pessoa de Meia-Idade , Adulto , Estudos Retrospectivos , Idoso , Neoplasias Uveais/diagnóstico por imagem , Neoplasias Uveais/patologia , Segmento Anterior do Olho/diagnóstico por imagem , Segmento Anterior do Olho/patologia , Neoplasias da Íris/diagnóstico por imagem , Adulto Jovem , Doenças da Íris/diagnóstico por imagem , Iris/diagnóstico por imagem , Iris/patologia , Adolescente
7.
BMJ Case Rep ; 17(5)2024 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-38719268

RESUMO

A young a presented with painless, progressive diminution of vision in both eyes (BE). Slit lamp examination revealed the presence of a single central corneal opacity in the right eye and multiple corneal opacities of varying sizes in the left eye (LE), limited to the anterior-mid corneal stroma. Microcornea with reduced central corneal thickness and complete inferonasal iris coloboma along with inferior fundal coloboma, sparing both the disc and macula, were noted in BE. A diagnosis of BE macular corneal dystrophy (MCD) and iridofundal coloboma (IFC) was made. The patient underwent LE sutureless anterior lamellar therapeutic keratoplasty. On histopathological examination, the excised corneal tissue revealed stromal lamellar disarray with positive colloidal iron staining, strongly suggestive of MCD. Whole-exome sequencing revealed the presence of a likely pathogenic carbohydrate sulfotransferase 6 (CHST6) mutation, confirming the diagnosis of MCD. This concurrent presence of IFC with a corneal stromal dystrophy is previously unreported in the literature, to the best of our knowledge.


Assuntos
Coloboma , Distrofias Hereditárias da Córnea , Humanos , Coloboma/genética , Coloboma/diagnóstico , Coloboma/complicações , Distrofias Hereditárias da Córnea/genética , Distrofias Hereditárias da Córnea/diagnóstico , Distrofias Hereditárias da Córnea/complicações , Distrofias Hereditárias da Córnea/cirurgia , Masculino , Iris/anormalidades , Iris/patologia , Carboidrato Sulfotransferases , Sulfotransferases/genética , Transplante de Córnea/métodos , Opacidade da Córnea/genética , Opacidade da Córnea/diagnóstico , Opacidade da Córnea/complicações , Córnea/anormalidades , Córnea/patologia
8.
Indian J Ophthalmol ; 72(6): 920, 2024 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-38804805

RESUMO

BACKGROUND: Glaucoma, the silent thief of sight, is one of the most common vision-threatening conditions. Even though POAG (primary open angle glaucoma) is more common, PACG (primary angle closure glaucoma) is the dreaded variant. ISGEO (International Society for Geographical and Epidemiological Ophthalmology) has classified primary angle closure as PACS (primary angle closure suspect), PAC (primary angle closure), and PACG (primary angle closure glaucoma. The inconspicuous nature of PACS makes its diagnosis and treatment very tricky. PURPOSE: To determine which cases are best suited for laser peripheral iridotomy. SYNOPSIS: Laser peripheral iridotomy is the gold standard for acute primary angle closure glaucoma treatment. But there is a lot of confusion regarding its use in PACS as a prophylactic measure. We have tried to throw light on laser peripheral iridotomy, a much debatable topic. The video focuses on various trials regarding laser peripheral iridotomy, the indications, side effects, and contraindications. We have also discussed its use as a therapeutic and prophylactic procedure. HIGHLIGHTS: The video highlights that the approach of laser peripheral iridotomy should be on a case-by-case basis. VIDEO LINK: https://youtu.be/kiEYI9ct2Oo.


Assuntos
Glaucoma de Ângulo Fechado , Pressão Intraocular , Iridectomia , Iris , Terapia a Laser , Humanos , Glaucoma de Ângulo Fechado/cirurgia , Glaucoma de Ângulo Fechado/diagnóstico , Glaucoma de Ângulo Fechado/fisiopatologia , Iridectomia/métodos , Pressão Intraocular/fisiologia , Terapia a Laser/métodos , Iris/cirurgia , Gonioscopia
9.
BMJ Case Rep ; 17(5)2024 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-38782424

RESUMO

The authors describe a case of reverse pupillary block with pigment dispersion following sequential phakic intraocular lens (pIOL) implantation for high myopia, in a young female patient. The intraocular pressure (IOP) elevation began 3 weeks postoperatively, for which Nd-YAG laser peripheral iridotomies (PIs) were attempted elsewhere. Despite maximum medical therapy, the IOP was uncontrolled. She was referred to our institute for further management. Examination showed anteriorly displaced iris-pIOL diaphragm, iris pigment dispersion and raised IOP. The PIs were incomplete. Based on clinical evaluation and investigations, we concluded that the excess area of contact of the posterior iris over the pIOL caused a reverse pupillary block and pigment dispersion. The IOPs were controlled by repeating laser iridotomies and with medical therapy. Subsequently, the patient developed a low lens vault leading to bilateral cataract. Sequential explantation of the pIOL along with cataract extraction was performed and her vision was restored.


Assuntos
Pressão Intraocular , Implante de Lente Intraocular , Lentes Intraoculares Fácicas , Distúrbios Pupilares , Humanos , Feminino , Lentes Intraoculares Fácicas/efeitos adversos , Distúrbios Pupilares/etiologia , Implante de Lente Intraocular/efeitos adversos , Implante de Lente Intraocular/métodos , Adulto , Miopia/cirurgia , Hipertensão Ocular/etiologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Iris/cirurgia , Extração de Catarata/efeitos adversos , Extração de Catarata/métodos
10.
Anat Histol Embryol ; 53(3): e13052, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38735035

RESUMO

One crucial component of the optical system is the ciliary body (CB). This body secretes the aqueous humour, which is essential to maintain the internal eye pressure as well as the clearness of the lens and cornea. The histological study was designed to provide the morphological differences of CB and iris in the anterior eye chambers of the following vertebrate classes: fish (grass carp), amphibians (Arabian toad), reptiles (semiaquatic turtle, fan-footed gecko, ocellated skink, Egyptian spiny-tailed lizard, Arabian horned viper), birds (common pigeon, common quail, common kestrel), and mammals (BALB/c mouse, rabbit, golden hamster, desert hedgehog, lesser Egyptian jerboa, Egyptian fruit bat). The results showed distinct morphological appearances of the CB and iris in each species, ranging from fish to mammals. The present comparative study concluded that the morphological structure of the CB and iris is the adaptation of species to either their lifestyle or survival in specific habitats.


Assuntos
Corpo Ciliar , Iris , Animais , Corpo Ciliar/anatomia & histologia , Iris/anatomia & histologia , Coelhos/anatomia & histologia , Camundongos/anatomia & histologia , Lagartos/anatomia & histologia , Vertebrados/anatomia & histologia , Répteis/anatomia & histologia , Peixes/anatomia & histologia , Aves/anatomia & histologia , Câmara Anterior/anatomia & histologia , Tartarugas/anatomia & histologia , Carpas/anatomia & histologia , Camundongos Endogâmicos BALB C , Anfíbios/anatomia & histologia , Cricetinae , Codorniz/anatomia & histologia , Ouriços/anatomia & histologia , Columbidae/anatomia & histologia , Mesocricetus/anatomia & histologia
11.
Zhonghua Yan Ke Za Zhi ; 60(5): 416-422, 2024 May 11.
Artigo em Chinês | MEDLINE | ID: mdl-38706079

RESUMO

Objective: To investigate the clinical characteristics and treatment outcomes of glaucoma secondary to congenital ectropion uveae (CEU) using penetrating Schlemm's canaloplasty. Methods: This was a retrospective case series study. Medical records of patients diagnosed with glaucoma secondary to CEU and undergoing penetrating Schlemm's canaloplasty at the Eye Hospital of Wenzhou Medical University between August 2020 and December 2021 were collected. Clinical characteristics including the extent and location of iris ectropion, type of glaucoma, were analyzed. Follow-up visits were conducted at 1, 3, 6 months, and 1 year postoperatively. Visual acuity, intraocular pressure (IOP), anterior segment and fundus condition, filtering bleb morphology, use of IOP-lowering medications, ultrasound biomicroscopy results, and other indicators were analyzed to summarize surgical outcomes. Results: Six cases (6 eyes) of glaucoma secondary to CEU were included, all unilateral, with 3 left eyes and 3 right eyes; median age was 10.0 (5.3, 28.8) years; including 3 males and 3 females. Preoperative IOP was (31.7±10.0) mmHg (1 mmHg=0.133 kPa), and the preoperative number of IOP-lowering medications used was 2.0 (2.0, 3.2). The extent of iris ectropion in the 6 cases ranged from 270 ° to 360 °, with peripheral anterior synechiae corresponding to the location of iris ectropion, and angle closure with the degree of synechiae extending beyond Schwalbe's line. No surgical complications occurred in any of the 6 cases postoperatively. At 1 month postoperatively, the IOP was (16.4±3.2) mmHg, with a median of 0.0 (0.0, 1.5) medications used. At 3 months postoperatively, the IOP was (14.8±6.0) mmHg, with a median of 0.0 (0.0, 2.2) medications used. At 6 months postoperatively, the IOP was (18.1±6.1) mmHg, with a median of 0.0 (0.0, 0.5) medications used. Among them, 5 patients had a follow-up period of 1 year postoperatively, all achieving controlled IOP without the use of IOP-lowering medications, with an average IOP of (15.5±3.1) mmHg. No obvious filtering bleb formation was observed at the surgical site in all patients. Conclusions: Glaucoma secondary to CEU manifests primarily as closed-angle glaucoma, with a correspondence between the closure range of anterior iris adhesions in the angle and the extent of iris ectropion. Penetrating Schlemm's canaloplasty demonstrates favorable and stable efficacy for its treatment.


Assuntos
Ectrópio , Glaucoma , Pressão Intraocular , Humanos , Estudos Retrospectivos , Masculino , Feminino , Glaucoma/cirurgia , Glaucoma/etiologia , Ectrópio/etiologia , Ectrópio/cirurgia , Criança , Pré-Escolar , Adulto , Úvea/cirurgia , Cirurgia Filtrante/métodos , Resultado do Tratamento , Acuidade Visual , Iris/cirurgia , Adulto Jovem , Adolescente
12.
Invest Ophthalmol Vis Sci ; 65(5): 13, 2024 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-38713484

RESUMO

Purpose: The purpose of this study was to measure intraocular pressure (IOP) elevation while applying standard gonioscopy, selective laser trabeculoplasty (SLT), and laser iridotomy procedural lenses. Methods: Twelve cadaver eyes were mounted to a custom apparatus and cannulated with a pressure transducer which measured IOP. The apparatus was mounted to a load cell which measured the force on the eye. Six ophthalmologists performed simulated gonioscopy (Sussman 4 mirror lens), SLT (Latina lens), and laser iridotomy (Abraham lens) while a computer recorded IOP (mm Hg) and force (grams). The main outcome measures were IOP and force applied to the eye globe during ophthalmic diagnostics and procedures. Results: The average IOP's during gonioscopy, SLT, and laser iridotomy were 43.2 ± 16.9 mm Hg, 39.8 ± 9.9 mm Hg, and 42.7 ± 12.6 mm Hg, respectively. The mean force on the eye for the Sussman, Latina, and Abraham lens was 40.3 ± 26.4 grams, 66.7 ± 29.8 grams, and 65.5 ± 35.9 grams, respectively. The average force applied to the eye by the Sussman lens was significantly lower than both the Latina lens (P = 0.0008) and the Abraham lens (P = 0.001). During gonioscopy indentation, IOP elevated on average to 80.5 ± 22.6 mm Hg. During simulated laser iridotomy tamponade, IOP elevated on average to 82.3 ± 27.2 mm Hg. Conclusions: In cadaver eyes, the use of standard ophthalmic procedural lenses elevated IOP by approximately 20 mm Hg above baseline.


Assuntos
Cadáver , Gonioscopia , Pressão Intraocular , Iris , Terapia a Laser , Trabeculectomia , Humanos , Pressão Intraocular/fisiologia , Terapia a Laser/métodos , Iris/cirurgia , Trabeculectomia/métodos , Tonometria Ocular , Idoso , Iridectomia/métodos , Feminino , Masculino , Idoso de 80 Anos ou mais
13.
J AAPOS ; 28(3): 103922, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38679138

RESUMO

PURPOSE: To report the long-term clinical and endothelial cell count (ECC) results of lensectomy with primary anterior chamber iris claw lens implantation in the eyes of patients ≤18-year-old with ectopia lentis due to Marfan syndrome. METHODS: The medical records of Marfan patients operated on at a single institution from September 2007 to August 2020, with minimum follow-up of 2 years, were reviewed retrospectively. The following data were analyzed: sex, age at surgery, indication for surgery, the position of the lens in relation to the undilated and dilated pupil, corneal endothelial cell counts (ECC), peri- and postoperative complications, pre- and postoperative best-corrected visual acuity. RESULTS: A total of forty-two eyes of 23 patients (12 girls and 11 boys) were included. At least two or more postoperative ECCs were collected from 33 eyes (17 patients). Median age at IOL implantation was 6.1 years (range, 1.8-18). Median overall follow-up time was 6.2 years (range, 2-13.5). Median ECC follow-up time was 6.2 years (range, 2-10). Mean best-corrected visual acuity was 0.71 ± 0.38 logMAR before surgery and 0.02 ± 0.25 logMAR at final follow-up. The mean annual ECC decline was 0.71% ± 2.24. Total cell loss from first to last postoperative measurement was 150 cells ± 394 cells/mm2 (4.81%). Pre- and first postoperative data were available for 17 eyes of 10 patients, with a mean cell loss before and directly after surgery of 269 ± 268 cells (7.94%). Surgery related complications were iris bombé due to blockage of peripheral iridectomy in 3 eyes and claw dislocation due to direct impact trauma in 3 eyes. CONCLUSIONS: In our large, pediatric study cohort, anterior chamber iris claw IOL implantation resulted in an excellent visual outcome and normal endothelial cell loss compared with normative data. Safety measures are recommended to avoid traumatic dislocation of IOLs.


Assuntos
Câmara Anterior , Ectopia do Cristalino , Iris , Implante de Lente Intraocular , Síndrome de Marfan , Acuidade Visual , Humanos , Ectopia do Cristalino/cirurgia , Síndrome de Marfan/complicações , Síndrome de Marfan/cirurgia , Feminino , Masculino , Criança , Implante de Lente Intraocular/métodos , Estudos Retrospectivos , Acuidade Visual/fisiologia , Pré-Escolar , Adolescente , Iris/cirurgia , Câmara Anterior/patologia , Seguimentos , Lactente , Lentes Intraoculares , Complicações Pós-Operatórias , Endotélio Corneano/patologia , Contagem de Células
14.
BMC Ophthalmol ; 24(1): 188, 2024 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-38654174

RESUMO

BACKGROUND: Ultrasound cycloplasty is a noninvasive surgery used to reduce intraocular pressure in patients with glaucoma, with fewer severe complications. This report presents several cases of iris neovascularization and neurotrophic keratopathy following ultrasound cycloplasty. CASE PRESENTATION: Six patients diagnosed with refractory glaucoma underwent ultrasound cycloplasty at our clinic. Three cases developed iris neovascularization at postoperative day 3, week 2 and week 4 respectively, with intraocular pressure ranging from 12 to 24 mmHg. The other three cases developed neurotrophic keratopathy at postoperative week 3, week 6 and week 8 which completely healed within 60 days. CONCLUSIONS: Iris neovascularization and neurotrophic keratopathy can be triggered after ultrasound cycloplasty, which are uncommon and self-limited but potentially vision-threatening. Preoperative risk assessment and regular postoperative follow-up are recommended to manage complications effectively.


Assuntos
Glaucoma , Pressão Intraocular , Iris , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças da Córnea/cirurgia , Doenças da Córnea/etiologia , Glaucoma/cirurgia , Pressão Intraocular/fisiologia , Iris/cirurgia , Iris/irrigação sanguínea , Iris/diagnóstico por imagem , Neovascularização Patológica , Complicações Pós-Operatórias
15.
JCI Insight ; 9(7)2024 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-38587075

RESUMO

Inflammatory lymphangiogenesis is intimately linked to immune regulation and tissue homeostasis. However, current evidence has suggested that classic lymphatic vessels are physiologically absent in intraocular structures. Here, we show that neolymphatic vessels were induced in the iris after corneal alkali injury (CAI) in a VEGFR3-dependent manner. Cre-loxP-based lineage tracing revealed that these lymphatic endothelial cells (LECs) originate from existing Prox1+ lymphatic vessels. Notably, the ablation of iridial lymphangiogenesis via conditional deletion of VEGFR3 alleviated the ocular inflammatory response and pathological T cell infiltration. Our findings demonstrate that iridial neolymphatics actively participate in pathological immune responses following injury and suggest intraocular lymphangiogenesis as a valuable therapeutic target for the treatment of ocular inflammation.


Assuntos
Lesões da Córnea , Linfangiogênese , Humanos , Linfangiogênese/fisiologia , Células Endoteliais , Álcalis , Linfócitos T , Inflamação , Iris
17.
Cryo Letters ; 45(2): 69-87, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38557986

RESUMO

Despite the routine use of cryopreservation for the storage of biological materials, its outcomes are often sub-optimal (including reduced post-thaw viability, recovery, and functionality) due to the damage caused by uncontrolled ice growth. Traditional cryoprotective agents (CPAs), including dimethyl sulfoxide (DMSO), fail to prevent damage caused by ice growth and concerns over CPA cytotoxicity have fostered an increased interest in developing improved CPAs and cryoprotection strategies. The inhibition of ice recrystallization by natural antifreeze (glyco)proteins [AF(G)Ps] to improve cryopreservation outcomes has been examined; however, the ice binding properties of these substances and their challenging large-scale production make them poor CPA candidates. Therefore, the development and deployment of biocompatible, small-molecule ice recrystallization inhibitors (IRIs) for use as CPAs is a worthwhile objective. Extensive structure-activity relationship studies on AF(G)Ps revealed that simple carbohydrate derivatives could inhibit ice recrystallization. It was later discovered that this activity could be fine-tuned by delicately balancing the molecule's hydrophobicity and hydrophilicity. Current generation small-molecule IRIs have been meticulously designed to avoid binding to the surface of ice and subsequent biological testing (for both cytotoxicity and cryopreservation efficacy) has demonstrated significant improvements to the cryopreservation outcomes of several cell types. However, an individualized cell-specific approach for the simultaneous assessment of multiple cryopreservation outcomes is necessary to realize the full potential of IRIs as CPAs. This article provides a detailed overview of the development of small-molecule carbohydrate-based IRIs and highlights the crucial cell-specific biological considerations that must be taken into account when assessing cryopreservation outcomes. https://doi.org/10.54680/fr24210110112.


Assuntos
Criopreservação , Gelo , Sobrevivência Celular , Crioprotetores/farmacologia , Crioprotetores/química , Carboidratos , Iris
18.
Rom J Ophthalmol ; 68(1): 13-18, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38617724

RESUMO

Aim: To compare the anatomical and functional results and patient satisfaction following retropupillary implantation of Artisan Aphakia iris-fixated intraocular lens (rAAIF) and sutured scleral fixated intraocular lens (SFIOL). Subjects and methods: We presented a prospective double-arm non-blinded study. Forty-one eyes with acquired aphakia, no age-related macular degeneration, no previous keratoplasty, no combined procedures, no AC reaction (cells, fibrin), normal intraocular pressure, no history of endothelial corneal dystrophy in relatives or fellow eye were included. Indications, complications, corrected distance visual acuity (CDVA), endothelial cell density (ECD), and patient satisfaction score were assessed. Results: Retropupillary AAIF was implanted in 21 (51.22%) eyes and SFIOL in 20 (48.78%) eyes. The most common indication was complicated cataract surgery in 18 cases (43.90%), followed by trauma in 16 (39.02%), and spontaneous dislocation in 7 (17.07%). No difference between rAAIF and SFIOL in terms of sex, laterality (χ=0.13, p=0.72), indications (χ=0.78, p=0.68), previous ocular history, and comorbidities was observed. The complications and the visual outcomes at 6 months postoperatively were similar between the two groups (p=0.95 and p=0.321, respectively). The ECD loss in the two groups was also similar (p=0.89). The patient satisfaction score was 58.67±8.80 in the rAAIF and 56.69±11.50 in the SFIOL group, which was statistically similar (p=0.764). Conclusion: Retropupillary AAIF and SFIOL showed similar results concerning visual acuity, endothelial cell loss, and patient satisfaction. Careful preoperative individual assessment is required to have optimal results with either technique. Abbreviations: AAIF = Artisan Aphakia iris-fixated intraocular lens, rAAIF = retropupillary Artisan Aphakia iris-fixated intraocular lens, CDVA = corrected distance visual acuity, ECD = endothelial cell density, IOL = intraocular lens, SD = standard deviation, SFIOL = scleral fixated intraocular lens.


Assuntos
Afacia , Lentes Intraoculares , Humanos , Estudos Prospectivos , Iris/cirurgia , Esclera/cirurgia
19.
Int Ophthalmol ; 44(1): 198, 2024 Apr 25.
Artigo em Inglês | MEDLINE | ID: mdl-38662107

RESUMO

PURPOSE: Cataract surgery in microphthalmic eyes is challenging due to anatomical restraints, hard bulky nucleus. This series aims to evaluate the safety and efficacy of couching of intraocular lens in irido-fundal coloboma with microphthalmos. SETTING: Tertiary care centre in South India. DESIGN: Retrospective non-comparative study in eyes with irido-fundal coloboma, corneal diameter < 7 mm and brown cataract. Visual acuity less than 6/60 in other eye. METHODS: Anterior chamber entry made, zonules broken and lens dislocated into the vitreous cavity in a controlled manner. Baseline Clinico-demographic details, corrected distance visual acuity (CDVA), Intra-ocular pressure (IOP), corneal diameter, axial length, lens status and post-surgery CDVA, IOP and complications recorded and followed up for atleast 6 months. RESULTS: Fifteen eyes of 15 subjects were evaluated with a mean age 49.4 ± 10.9 years. At baseline, mean IOP 14.5 ± 3.8 mmHg, mean axial length 19.3 ± 0.5 mm, mean corneal diameter was 6.5 ± 0.34 mm and CDVA 2 logMAR which improved to 1.5 logMAR at 3 months (p value 0.002). Transient spike in IOP in 33.3% subjects was medically managed with no significant difference in IOP (p > 0.05) at baseline (14.5 ± 3.8 mmHg), 3 months post-surgery (16 ± 2.8 mmHg) and 6 months post-surgery (14.9 ± 2.5 mmHg). One patient underwent re-couching. No other major complications were noted. CONCLUSION: Couching of cataractous lens is an effective and safe method in microphthalmic eyes with irido-fundal coloboma as last resort procedure, where no other surgical procedure may work. It provides an ambulatory gain of visual acuity in previously non-ambulatory subjects. Corneal measurements help in determining the subset of patients where couching offers viable option.


Assuntos
Catarata , Coloboma , Microftalmia , Acuidade Visual , Humanos , Estudos Retrospectivos , Feminino , Coloboma/diagnóstico , Coloboma/complicações , Coloboma/cirurgia , Masculino , Microftalmia/complicações , Microftalmia/diagnóstico , Microftalmia/cirurgia , Catarata/complicações , Catarata/congênito , Catarata/diagnóstico , Pessoa de Meia-Idade , Adulto , Iris/cirurgia , Iris/anormalidades , Implante de Lente Intraocular/métodos , Extração de Catarata/métodos , Cristalino/anormalidades , Cristalino/cirurgia , Seguimentos
20.
Arq Bras Oftalmol ; 87(4): e2022, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38656019

RESUMO

We present a case report detailing the successful phacoemulsification surgery with artificial iris implantation for two individuals with oculocutaneous albinism. These women suffered from cataracts, resulting in reduced visual acuity and heightened photophobia due to iris pigmentary epithelium deficiency. The patients underwent phacoemulsification along with prosthetic artificial iris implantation into the posterior chamber. This intervention resulted in improved visual acuity, reduced photophobia and glare, and an overall enhanced quality of life. Our report highlights two cases of successful phacoemulsification and artificial iris implantation in patients with oculocutaneous albinism and cataracts, leading to improved visual acuity, reduced photophobia, and enhanced quality of life. Notably, there are no prior records in South American literature of cataract surgery combined with artificial iris implantation for oculocutaneous albinism patients up to the time of this publication.


Assuntos
Albinismo Oculocutâneo , Iris , Facoemulsificação , Acuidade Visual , Humanos , Albinismo Oculocutâneo/cirurgia , Albinismo Oculocutâneo/complicações , Feminino , Iris/cirurgia , Facoemulsificação/métodos , Resultado do Tratamento , Catarata/complicações , Catarata/congênito , Qualidade de Vida , Adulto , Órgãos Artificiais , Implantação de Prótese/métodos , Pessoa de Meia-Idade , Fotofobia/cirurgia , Fotofobia/etiologia
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