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1.
Magn Reson Imaging Clin N Am ; 30(1): 35-51, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34802580

RESUMO

MR imaging is the modality of choice in the evaluation of oral cavity and oropharyngeal cancer. Routine postcontrast MR imaging is important for the accurate localization and characterization of the locoregional extension of oral cavity and oropharyngeal cancers. The anatomy of the oral cavity and oropharynx is complex; accurate interpretation is vital for description of the extension of the masses. Understanding the new changes in the eighth edition of the American Joint Committee on Cancer staging system. MR imaging is the imaging modality of choice for detection of perineural spread.


Assuntos
Imageamento por Ressonância Magnética , Neoplasias Orofaríngeas , Humanos , Boca/diagnóstico por imagem , Boca/patologia , Estadiamento de Neoplasias , Neoplasias Orofaríngeas/diagnóstico por imagem , Neoplasias Orofaríngeas/patologia
2.
Rev. Odontol. Araçatuba (Impr.) ; 42(3): 50-55, set.-dez. 2021.
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-1291673

RESUMO

A pandemia gerada pelo SARS-CoV-2 gerou uma série de estudos sobre essa nova doença. Este cenário proporcionou mudanças na odontologia, modificando a forma de atendimento e a rotina do consultório. O conhecimento sobre as implicações desse vírus no sistema estomatognático pode fornecer informações valiosas no conhecimento sobre o mecanismo dessa doença na cavidade oral. Dessa forma, foi realizada uma revisão de literatura, a fim de discutir os efeitos do COVID-19 na cavidade oral. No entanto, há poucas evidências na literatura sobre a correlação da COVID-19 e manifestações orais. Pode-se concluir que o vírus possui reflexo na cavidade oral, apresentando diferentes alterações, tais como: úlceras, periodontite, alterações do paladar, infecções oportunistas, dentre outras. Ainda se faz necessária a realização de mais estudos, para compreensão dos mecanismos fisiopatológicos da doença. Além disso, o trabalho ressalta a importância do cirurgião-dentista no ambiente hospitalar, para diagnóstico e conduta no tratamento dessas manifestações na cavidade oral(AU)


The SARS-CoV-2 pandemic has spawned several studies on this new disease. This scenario provided changes in Dentistry by modifying the form of care and the routine of the office. The knowledge about the implications of this virus in the stomatognathic system can provide valuable information in the knowledge about the mechanism of this disease in the oral cavity. Thus, a literature review was carried out to discuss the effects of COVID-19 on the oral cavity. However, there is little evidence in the literature about the correlation between COVID-19 and oral manifestations. It can be concluded that the virus is reflected in the oral cavity, such as ulcers, periodontitis, changes in taste, opportunistic infections, among others. Further studies are still needed to understand the pathophysiological mechanisms of the disease. Besides, the work highlights the importance of the Dental Surgeon in the hospital environment for diagnosis and management in the treatment of these manifestations in the oral cavity(AU)


Assuntos
Manifestações Bucais , Assistência Odontológica , COVID-19 , Periodontite , Úlcera , Infecções Oportunistas , Sistema Estomatognático , Odontólogos , Boca
3.
BMC Oral Health ; 21(1): 567, 2021 11 08.
Artigo em Inglês | MEDLINE | ID: mdl-34749700

RESUMO

BACKGROUND: The oral cavity represents a main entrance of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Angiotensin-converting enzyme 2 (ACE-2), neuropilin-1 (NRP-1), and transmembrane serine protease 2 (TMPRSS2) are essential for the entry of SARS-CoV-2 to the host cells. Both ACE-2 and NRP-1 receptors and TMPRSS2 have been identified in the oral cavity. However, there is limited knowledge about the impact of periapical lesions and their metabolites on the expression of these critical genes. This study aims to measure the impact of periapical lesions and their unique fatty acids (FAs) metabolites on the expression of the aforementioned genes, in addition to interleukin 6 (IL-6) gene and hence SARS-CoV-2 infection loads can be estimated. METHODS: Gene expression of ACE-2, NRP-1, TMPRSS2, and IL-6 was performed in periapical lesions in comparison to healthy oral cavity. Since FAs are important immunomodulators required for the lipid synthesis essential for receptors synthesis and viral replication, comparative FAs profiling was determined in oral lesions and healthy pulp tissues using gas chromatography-mass spectrometry (GC-MS). The effect of major identified and unique FAs was tested on mammalian cells known to express ACE-2, NRP-1, and TMPRSS2 genes. RESULTS: Gene expression analysis indicated that ACE-2, NRP-1, and TMPRSS2 were significantly upregulated in healthy clinical samples compared to oral lesions, while the reverse was true with IL-6 gene expression. Saturated and monounsaturated FAs were the major identified shared and unique FAs, respectively. Major shared FAs included palmitic, stearic and myristic acids with the highest percentage in the healthy oral cavity, while unique FAs included 17-octadecynoic acid in periapical abscess, petroselinic acid and L-lactic acid in periapical granuloma, and 1-nonadecene in the radicular cyst. Computational prediction showed that the binding affinity of identified FAs to ACE-2, TMPRSS2 and S protein were insignificant. Further, FA-treated mammalian cells showed significant overexpression of ACE-2, NRP-1 and TMPRSS2 genes except with L-lactic acid and oleic acid caused downregulation of NRP-1 gene, while 17-octadecynoic acid caused insignificant effect. CONCLUSION: Collectively, a healthy oral cavity is more susceptible to viral infection when compared to that complicated with periapical lesions. FAs play important role in viral infection and their balance can affect the viral loads. Shifting the balance towards higher levels of palmitic, stearic and 1-nonadecene caused significant upregulation of the aforementioned genes and hence higher viral loads. On the other hand, there is a reverse correlation between inflammation and expression of SARS-CoV-2 receptors. Therefore, a mouth preparation that can reduce the levels of palmitic, stearic and 1-nonadecene, while maintaining an immunomodulatory effect can be employed as a future protection strategy against viral infection.


Assuntos
COVID-19 , SARS-CoV-2 , Animais , Humanos , Boca , Carga Viral
4.
Stomatologiia (Mosk) ; 100(5): 71-76, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34752039

RESUMO

THE PURPOSE OF THE STUDY: To show the effectiveness of the use of the drug Panavir in patients with a combined clinical manifestation of viral herpetic lesions of the oral mucosa and genital area. MATERIAL AND METHODS: Patient S., 42 years old, complained of discomfort, pain and rashes in the mouth and on the genitals. To assess the patient's condition, clinical (dental examination using luminescent stomatoscopy and dermatovenerological examination) and laboratory methods were used: clinical blood and urine tests, microscopy of smears from the urethra, cervical canal, vagina, rectum and PCR-examination of the discharge from the elements of the lesion of the oral mucosa, urethra, cervical canal and the contents of vesicular rashes on the skin of the perianal area. RESULTS: The prescribed antiviral treatment with the inclusion of 0.004% Panavir scheme in the form of injections and drugs for topical use on the oral mucosa, genitals and on the skin, made it possible to quickly achieve a resolution of the inflammatory infectious process. On the third day after the start of therapy, the patient noted a decrease in the area of inflammation. Subjective sensations in the form of discomfort during urination, burning and soreness in the foci were leveled. After 7 days, the foci in the mouth and on the skin of the perianal area completely regressed. CONCLUSION: The use of Panavir in the complex treatment of severe forms of recurrent herpes virus lesions of the oral mucosa and genital area has shown its high efficiency, good tolerability, no side effects and an increase in the remission period.


Assuntos
Herpes Simples , Adulto , Antivirais/uso terapêutico , Feminino , Herpes Simples/tratamento farmacológico , Humanos , Boca
5.
J Contemp Dent Pract ; 22(8): 959-963, 2021 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-34753852

RESUMO

AIM: The present manuscript aims at providing a comprehensive overview of the epidemiology, risk factors, diagnostic aids, and management of halitosis in a pediatric population. BACKGROUND: Halitosis refers to bad breath from the mouth that seems unpleasant or offensive to others. This condition is prevalent worldwide, including all age-groups. However, studies on the pediatric population are limited. Self-confidence and personality development are important factors that the child builds up during their developmental stages. Halitosis may affect them both on personal and social aspects; hence, it is important to have beforehand knowledge and the modes to intercept it, paving the way to a positive growth of the child. REVIEW RESULTS: On reviewing the literature, the common risk factors for halitosis in children constituted predominantly oral factors that varied from poor oral hygiene, gingivitis, periodontal diseases, dental caries, tongue coating, mouth breathing, and so on. Their diagnosis commonly included the organoleptic test, sulfide monitoring, and gas chromatography along with the assessment of questionnaire by the parents and older children. The management was predominantly directed toward the identified source of halitosis along with instructions and counseling on the benefits of a good oral hygiene regime. CONCLUSION: The importance of cultivating a day-to-day practice of oral hygiene regime in the children will not only accustom them toward the benefits of good oral health but also help them to tackle halitosis and in turn their inhibitions associated with it. CLINICAL SIGNIFICANCE: Halitosis, though a prevalent condition experienced at various stages of life, is crucial to identify and manage, especially in the pediatric population owing to its influence on personal and on social aspects of life.


Assuntos
Cárie Dentária , Halitose , Adolescente , Criança , Halitose/diagnóstico , Halitose/epidemiologia , Halitose/etiologia , Humanos , Boca , Fatores de Risco , Língua
6.
Niger J Clin Pract ; 24(11): 1689-1693, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34782510

RESUMO

Background: Sleeve gastrectomy is a stapler dependent bariatric procedure. A stapleless sleeve gastrectomy can be necessary for certain circumstances. Aims: Here, we aimed to show whether laparoscopic stapleless sleeve gastrectomy with natural orifice specimen extraction (NOSE) can be an alternative procedure to stapled sleeve gastrectomy. Patients and Methods: In the stapleless group (n = 6), no staplers were used and after vertical resection of the stomach by energy devices, the stomach remnant was closed by two rows of intracorporeal sutures. The resected specimen was removed through the mouth using an endoscopic snare. In the stapler group (n = 7), sleeve gastrectomy was carried out with linear stapler under the guidance of 36 Fr bougie. The specimens were extracted from the left upper quadrant trocar site. Results: A total of 13 patients were compared (stapleless = 6 and stapled group = 7). All the sleeve gastrectomies were completed laparoscopically. The operative time was longer at 200 minutes (range 120-300) versus 120 minutes, (range 90-200) p = 0.07) and the amount of bleeding was higher at 100 ml (range 50-200) versus 30 ml (range 10-50) (p = 0.004) in the stapleless group. Leakage and gastrointestinal bleeding were seen in the stapleless group but no complications were found in the stapler group. No statistically significant difference was found between the metabolic outcomes of the two groups after the operation (p > 0.05). Decrease in BMI at similar rates was observed in 5 postoperative year (stapleless group: 35 kg/m2 (range 31-39) versus stapled group: 36.5 kg/m2 (range 31-39), p > 0.05). Conclusion: Laparoscopic stapleless sleeve gastrectomy with natural orifice specimen extraction has longer procedure time, more blood loss and complications.


Assuntos
Laparoscopia , Gastrectomia , Humanos , Boca , Duração da Cirurgia , Estômago
7.
Pol Merkur Lekarski ; 49(293): 382-384, 2021 Oct 22.
Artigo em Inglês | MEDLINE | ID: mdl-34800030

RESUMO

A significant increase is currently being observed in the number of patients hospitalized due to respiratory system diseases, such as chronic obstructive pulmonary disease (COPD), and bronchial asthma with a predominantly allergic component. Treatment of COPD and bronchial asthma is mainly based on the use of beta-2-mimetics and glucocorticosteroids (GCS). However, the GCS inhalation therapy may be associated with developing a risk of various types of complications, which are especially manifested in the initial part of the respiratory system. In the paper the side effects resulting from the chronic use of inhaled GCS was presented with discussion how to reduce their negative effects. The negative side effects of chronic GCS therapy for the treatment of pulmonary diseases result mainly from their modifying effect on the proper functioning of the immune system, and on their generation of salivary secretion disorders. When using inhaled GCS, drugs deposit on the mucosa membrane of the throat and oral cavity, which promotes the development of candidiasis which accompanied by xerostomia leads to difficulty in swallowing and speaking. The reduced salivation promotes the development of caries disease due to the impairment of the physiological mechanism of tooth surface cleaning. Attention to proper oral hygiene is fundamental and an appropriate antifungal therapy is required. When conducting a physical examination, it is important to pay attention to those patients using inhaled steroids, especially on a chronic basis. This is because with careful clinical evaluation, the side effects of these drugs can be detected at an early stage and the appropriate treatment of their negative effects can be applied.


Assuntos
Asma , Doença Pulmonar Obstrutiva Crônica , Administração por Inalação , Asma/induzido quimicamente , Asma/tratamento farmacológico , Humanos , Boca , Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico , Esteroides/uso terapêutico
8.
Int J Oral Implantol (Berl) ; 14(4): 401-416, 2021 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-34726849

RESUMO

PURPOSE: Long-term success of titanium dental implants is influenced by various factors, including the maintenance of good oral hygiene. The present study aimed to evaluate cleaning effectiveness and patient satisfaction with glycine powder air polishing and traditional professional oral hygiene treatments when applied to implant-supported full-arch restorations without removal of the fixed prosthesis. MATERIALS AND METHODS: A total of 85 patients with 357 implants supporting full-arch fixed restorations were included. After removal of the prosthesis (T0), the following parameters were recorded: Plaque Index, peri-implant spontaneous bleeding, probing depth and bleeding on probing. The prosthesis was then reinserted. The patients were divided into three groups, each of which received two hygiene therapies randomly administered in each hemiarch using a split-mouth design. The possible treatments were glycine powder air polishing and use of sponge floss vs sponge floss only in group 1; glycine powder air polishing vs use of an ultrasonic device with a polyetheretherketone fibre tip coating in group 2; and glycine powder air polishing vs use of carbon fibre curettes and sponge floss in group 3. After instrumentation, the prostheses were removed to assess the Plaque Index and peri-implant spontaneous bleeding. Questionnaires were used to record patients' levels of comfort and satisfaction in relation to the various treatments. RESULTS: Glycine powder air polishing resulted in a significantly higher reduction in plaque around implants compared to control treatments (sponge floss only, ultrasonic device with polyetheretherketone fibre tip coating, and manual scaling with carbon fibre curettes and use of sponge floss) (P = 0.020). Glycine powder air polishing followed by application of sponge floss provided the greatest reduction of plaque deposits on the prosthetic surfaces. On average, 80% of patients rated glycine powder air polishing highest with regard to satisfaction. CONCLUSIONS: Glycine powder air polishing is a highly effective and comfortable treatment to maintain good oral hygiene in clinical practice, and could be used as an alternative to manual and mechanical instrumentation when dealing with implant-supported restorations.


Assuntos
Implantes Dentários , Placa Dentária , Índice de Placa Dentária , Humanos , Boca , Índice Periodontal
10.
Acta Otorhinolaryngol Ital ; 41(5): 436-442, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34734579

RESUMO

Objectives: To evaluate the association between upper airway obstruction and occlusal anomalies in mouth-breathing children. Methods: 356 mouth-breathing children were evaluated by ENT physicians and specialists in orthodontics. ENT examination included nasal endoscopy to assess the adenoidal hypertrophy, tonsillar grading and presence of nasal septum deviation. Clinical orthodontic examination was performed to record occlusal variables. Univariate and multivariable logistic regression were performed to study the association between registered variables. Results: 221 patients (mean age ± sd = 6.2 ± 2.5 years) met inclusion criteria. 81.4% of children presented malocclusion. A significant association between tonsillar grade 2 and the presence of malocclusion, Class II relation and increased overjet was shown. Tonsillar grade 4 showed a significant association with the presence of malocclusion and increased overjet. Adenoidal hypertrophy and nasal septum deviation did not show any association with occlusal findings. Conclusions: A high frequency of orthodontic problems was seen in mouth-breathing children. Our results suggested that severe tonsillar hypertrophy may determine presence of malocclusion and increased overjet. On the other hand, the association between mild tonsillar hypertrophy and many occlusal anomalies in mouth-breathers suggest an important role of malocclusion in the onset of oral breathing in children.


Assuntos
Obstrução das Vias Respiratórias , Má Oclusão , Obstrução Nasal , Obstrução das Vias Respiratórias/complicações , Criança , Humanos , Má Oclusão/complicações , Má Oclusão/epidemiologia , Boca , Respiração Bucal/complicações , Septo Nasal
11.
Pulm Med ; 2021: 4712406, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34765263

RESUMO

Periodontal diseases are a range of polymicrobial infectious disorders, such as gingivitis and periodontitis, which affect tooth-supporting tissues and are linked to playing a role in the exacerbation of several pulmonary diseases. Pulmonary diseases, such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, tuberculosis, COVID-19, and bronchiectasis, significantly contribute to poor quality of life and mortality. The association between periodontal disease and pulmonary outcomes is an important topic and requires further attention. Numerous resident microorganisms coexist in the oral cavity and lungs. However, changes in the normal microflora due to oral disease, old age, lifestyle habits, or dental intervention may contribute to altered aspiration of oral periodontopathic bacteria into the lungs and changing inflammatory responses. Equally, periodontal diseases are associated with the longitudinal decline in spirometry lung volume. Several studies suggest a possible beneficial effect of periodontal therapy in improving lung function with a decreased frequency of exacerbations and reduced risk of adverse respiratory events and morbidity. Here, we review the current literature outlining the link between the oral cavity and pulmonary outcomes and focus on the microflora of the oral cavity, environmental and genetic factors, and preexisting conditions that can impact oral and pulmonary outcomes.


Assuntos
Microbiota , Boca/microbiologia , Doenças Periodontais/complicações , Doença Pulmonar Obstrutiva Crônica/complicações , Causalidade , Meio Ambiente , Humanos
12.
Zootaxa ; 5032(1): 136-142, 2021 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-34811138

RESUMO

The snailfish Osteodiscus abyssicola sp. nov. is described from a single specimen collected off the Pacific coast of Hokkaido, northern Japan, at a depth of 4,6714,744 m. It is distinguished from all currently recognized congeners by the following combination of characters: vertebrae 49; dorsal-fin rays 44; anal-fin rays 39; principal caudal-fin rays 8; pyloric caeca 5; mouth horizontal; teeth on both jaws simple and sharp, without cusps; upper and lower jaw symphyses without diastema; cephalic pore sizes moderate, similar to or slightly larger than nostril; gill slit extending ventrally to 2nd pectoral-fin ray base; pectoral fin notched; mandibular symphysis to center of anus 101.6% head length (HL); posterior edge of pelvic disk to center of anus 15.5% HL; epural 1, reduced; epipleural ribs absent. An emended diagnosis and key to the species of Osteodiscus are provided.


Assuntos
Gadiformes , Perciformes , Animais , Brânquias , Japão , Boca
13.
Georgian Med News ; (318): 43-49, 2021 Sep.
Artigo em Russo | MEDLINE | ID: mdl-34628377

RESUMO

The quality of the formation of the relief of the soft tissues of the prosthetic bed after surgical tooth extraction is a significant criterion for the success of further permanent removable prosthetics. However, after a surgical operation, an inflammatory response in the soft tissues of the oral cavity inevitably occurs, and their deformation also occurs. These processes can be aggravated due to insufficient control over inflammatory phenomena with possible functional overload of the prosthetic bed at the stage of primary orthopedic rehabilitation with the help of immediate prosthetics. Objectivity of monitoring the course of inflammation can be ensured using the methods of vital staining of the oral mucosa and analysis of the dynamics of vascular changes in the area of ​​surgical intervention. The use of iodine-containing diagnostic solutions, revealing an increased content of glycogen and inflammatory enzymes in the mucous membrane of this area, contributes to the early detection of the latent inflammatory process. Glycogen is the main energy source for cellular and glycolytic biochemical inflammatory reactions, and is also present in the adventitia of newly formed vessels in the focus of damage, and acts as a marker of changes in the density of the vascular network. Thus, the aim of the study is to optimize the control over the course of latent inflammation in the area of ​​the prosthetic bed at the stage of using removable lamellar immediate prostheses in patients with partial absence of teeth due to surgical extraction. The study included 2 groups of patients with the absence of 4 to 10 teeth due to surgical extraction. The study group of patients underwent the manufacture of lamellar immediate-prostheses under the control of diagnostic staining of the mucous membrane. For patients of the second group, prostheses were made using the traditional method. According to the results of the study, in the study group, the time for complete resolution of inflammatory phenomena and the formation of the optimal state of the prosthetic bed was reduced by 33% compared to the control group. It was found that early detection of foci of chronic inflammation in the area of ​​the prosthetic bed makes it possible to promptly correct the tactics of orthopedic treatment by transforming the bases of immediate prostheses, which generally increased the quality of early prosthetics in this study.


Assuntos
Prótese Parcial Removível , Mucosa Bucal , Humanos , Boca , Mucosa Bucal/cirurgia , Próteses e Implantes , Coloração e Rotulagem
14.
Prog Orthod ; 22(1): 37, 2021 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-34604918

RESUMO

BACKGROUND: The aims of this study were to evaluate the efficacy of alveolar corticotomy (AC) and piezocision (PZ) in accelerating maxillary canine retraction, and their effects on multiple bone remodeling expression in gingival crevicular fluid (GCF). A split-mouth, randomized controlled clinical trial was performed at the Department of Orthodontics of Pontifical Catholic University of Minas Gerais, Brazil. Eligibility criteria included orthodontic need for first maxillary premolars extractions, followed by canine retraction. Fifty-one adult patients were recruited and randomly assigned to 3 groups (allocation ratio 1:1:1). Random allocation of surgical or control interventions to each side of the maxillary arch was also conducted: G1 - AC × Control, G2 - PZ × Control, and G3 - AC × PZ. Both the definition of the group and the decision of the experimental or control sides were randomized by the software. Intraoral digital scans were performed before, 7 and 14 days after the beginning of canine retraction, and subsequently, at every 14 days until a maximum period of 6 months. GCF samples were collected before, and 1, 2, 4, 8, and 12 weeks. The primary outcome consisted in the cumulative distal movement of the canines and was measured by digital model superimposition. The secondary outcome consisted in GCF bone remodeling samples that were quantified in a multiplex immunoassay. The measurements examinator was properly blinded. RESULTS: Forty-seven patients, 19 males and 28 females, were analyzed (mean age 20.72, SD = 6.66, range 15 to 38). Statistically significant differences in canine distal movement between AC and control in G1 were not observed (p > 0.05). In G2, PZ showed lower cumulative incisal and cervical measurements than control from the 2nd to the 24th week (p < 0.05). In G3, PZ showed a lower cumulative incisal and cervical measurements than AC from the16th to the 24th week (p < 0.05). In all groups, differences on biomarkers expression occurred at specific timepoints (p < 0.05), but a distinct pattern was not observed. CONCLUSIONS: AC and PZ were not effective to accelerate maxillary canine retraction and did not induce a distinct pattern of biomarker expression. TRIAL REGISTRATION: NCT03089996 . Registered 24 March 2017 - Registered.


Assuntos
Líquido do Sulco Gengival , Boca , Adulto , Remodelação Óssea , Brasil , Hematopoiese Clonal , Feminino , Humanos , Masculino , Adulto Jovem
15.
Braz Dent J ; 32(2): 53-63, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34614061

RESUMO

The present study was a prospective, controlled, randomized, clinical short-term trial aiming to evaluate the clinical performance of adhesively luted, lithium disilicate and feldspathic glass-ceramics onlays over a period up to 2 years. A total of 11 patients (7 female, 4 male; age range: 18-60 years, mean age: 39 years) were selected for this study. Each patient received a maximum of two restorations per group in a split-mouth-design. LD: Eleven onlays, performed with lithium disilicate-based ceramic (IPS e.max CAD, Ivoclar Vivadent, Schaan, Liechtenstein), and FP: Eleven onlays, performed with feldspathic ceramic (Vita Mark II, Vita Zanhfabrik, Bad Säckingen). Recalls were performed at 2 weeks (baseline = R1), 1 year (R2) and 2 years (R3) after the cementation by three calibrated blinded independent investigators using mirrors, magnifying eyeglasses, probes and bitewing radiographs. The postoperative sensitivity, secondary caries, marginal integrity, marginal discoloration, color match, surface roughness, tooth integrity, and restoration integrity were evaluated. The Friedman test was used to determine if there was a statistically significant difference in time-to-time comparison of the parameters in the ceramics restorations. A total of 95.4% of the restorations were clinically acceptable at the 2-year recall, without a difference for any evaluation parameter for both ceramic materials. Based on the 2-year data, the CAD-CAM onlays manufactured with feldspathic and lithium-disilicate based ceramics showed similar clinical performance.


Assuntos
Restaurações Intracoronárias , Boca , Adolescente , Adulto , Porcelana Dentária , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Adulto Jovem
16.
BMC Infect Dis ; 21(1): 1067, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34654380

RESUMO

BACKGROUND: Myiasis is caused by dipterous larvae, and rarely affects the mouth. Diagnosis by traditional means is easy to be confused with other similar species. Here, we report a case of oral myiasis, in a 5-month-old infant who was diagnosed by morphological examination and molecular biological methods. CASE PRESENTATION: A 5-month old infant with acute myeloid leukemia was admitted due to recurrent skin masses for more than 4 months. The infant had lip swelling, which prevented him from closing the mouth and membranes were present in his mouth and there were also oral ulcers and erosions. Ten maggots were found in the mouth and one in the ear canal with pus flowing out and were confirmed as the third stage larvae of Sarcophaga ruficornis by morphological examination and a comparison of sequence of cytochrome oxidase subunit 1 (COX1) gene. After removal of the maggots and chemotherapy, the infant 's condition was gradually improved. CONCLUSIONS: To the best of our our knowledge, this is the first neonatal oral myiasis case reported in China and its diagnosis requires a high index of suspicion. Microscopy combined with specific DNA sequence analysis is an effective technological tool to provide rapid diagnoses of the larva specimen and cases of rare diseases, as illustrated in the current case.


Assuntos
Dípteros , Miíase , Sarcofagídeos , Animais , Humanos , Lactente , Larva , Masculino , Boca , Miíase/diagnóstico
17.
J Med Microbiol ; 70(10)2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34668852

RESUMO

Introduction . Capnocytophaga species are common inhabitants of the oral cavity and can be responsible for systemic diseases in immunocompromised patients with granulocytopenia. Furthermore, it has been reported that some clinical isolates of Capnocytophaga species produce extended-spectrum ß-lactamases (ESBLs).Gap statement. Information is lacking about the types of ß-lactamase genes possessed by Capnocytophaga spp. and the antimicrobial susceptibility of Capnocytophaga spp. possessing each ß-lactamase gene.Aim. The aim of this study was to investigate the presence of ß-lactamase genes in clinical strains of ß-lactamase-producing Capnocytophaga species isolated from clinical samples acquired at Shinshu University Hospital and examine the antimicrobial susceptibility of those strains.Methodology. The ß-lactamase-producing Capnocytophaga species (n=49) were obtained from clinical specimens. PCR assays were used to detect bla CfxA, bla CSP, bla TEM, bla CepA/CblA and transposon Tn4555 genes. Southern hybridization assays were used to detect bla CfxA and bla CSP. The minimum inhibitory concentration of some ß-lactams was determined using the E-test method.Results. PCR analysis indicated that the bla CfxA gene was present in 15 (30.6 %) and the bla CSP gene in 35 (69.3 %) of the 49 Capnocytophaga strains investigated, . Both bla CfxA and bla CSP genes were detected in a Capnocytophaga gingivalis strain. The PCR results were confirmed by Southern hybridization assays. Transposon Tn4555 was only detected in Capnocytophaga spp. harbouring the bla CfxA gene. All the ß-lactamase-producing Capnocytophaga isolates were susceptible to ceftazidime-clavulanic acid, cefoxitin and imipenem. In contrast, most of the isolates were resistant to amoxicillin.Conclusions. The clinical isolates of Capnocytophaga spp. showed a high prevalence of the bla CSP gene in Japan. The presence of the bla CSP gene was distributed in Capnocytophaga sputigena as well as other Capnocytophaga spp. These results seem to suggest the dissemination of bla CfxA and bla CSP ß-lactamase genes among Capnocytophaga species.


Assuntos
Capnocytophaga/genética , Resistência Microbiana a Medicamentos , Infecções por Bactérias Gram-Negativas/epidemiologia , Boca/microbiologia , beta-Lactamases/genética , Japão , Prevalência
18.
Am J Dent ; 34(5): 281-285, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34689453

RESUMO

PURPOSE: To evaluate the bleaching sensitivity and the bleaching effectiveness of in-office bleaching, following a protocol of complete cervical third protection with gingival dam in comparison with a traditional manner of applying gingival dam (used only in the gingival sulcus area). METHODS: 35 participants were selected for this double-blind split-mouth randomized clinical trial. The control group received the gingival barrier in the traditional manner, and in the experimental group the barrier was extended by about 3 mm to include the cervical region. The bleaching agent was applied in two sessions. The risk and intensity of bleaching sensitivity were assessed using two scales. The bleaching effectiveness was evaluated with a digital spectrophotometer with the tip placed in the cervical area. The absolute risk of bleaching sensitivity was compared by the McNemar's test and bleaching effectiveness (ΔEab, ΔE00 and ΔWi) and intensity of bleaching sensitivity was evaluated by Wilcoxon-paired test (α= 0.05). RESULTS: No significant difference at risk (P= 1.0) and intensity of bleaching sensitivity (P> 0.45) was seen between groups. After 30 days, bleaching effectiveness had no statistical difference between the groups (P> 0.09). CLINICAL SIGNIFICANCE: Extending the barrier in the cervical region of teeth did not reduce the risk and intensity of bleaching sensitivity, nor jeopardize the bleaching effectiveness.


Assuntos
Sensibilidade da Dentina , Clareadores Dentários , Clareamento Dental , Sensibilidade da Dentina/prevenção & controle , Humanos , Peróxido de Hidrogênio , Boca , Ensaios Clínicos Controlados Aleatórios como Assunto , Clareamento Dental/efeitos adversos , Clareadores Dentários/efeitos adversos , Resultado do Tratamento
19.
Front Cell Infect Microbiol ; 11: 714229, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34660339

RESUMO

Sex steroid hormones (SSH) are cholesterol-derived molecules. They are secreted into saliva and enter the oral cavity, triggering physiological responses from oral tissues, with possible clinical implications, such as gingival inflammation and bleeding. SSH and hormonal changes affect not only oral host cells but also oral microorganisms. Historically, most research has focused on the effect of hormonal changes on specific bacteria and yeasts. Recently a broader effect of SSH on oral microorganisms was suggested. In order to assess the role of SSH in host-microbe interactions in the oral cavity, this review focuses on how and up to what extent SSH can influence the composition and behavior of the oral microbiome. The available literature was reviewed and a comprehensive hypothesis about the role of SSH in host-microbiome interactions is presented. The limited research available indicates that SSH may influence the balance between the host and its microbes in the oral cavity.


Assuntos
Microbiota , Bactérias , Hormônios Esteroides Gonadais , Boca , Saliva
20.
Zoolog Sci ; 38(5): 397-404, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34664914

RESUMO

Vulnerability of animals immediately after hatching may induce plasticity in early ontology that becomes important for subsequent survival and growth. Ezo salamanders (Hynobius retardatus) are amphibians inhabiting ponds in Hokkaido, Japan where ezo brown frogs (Rana pirica) spawn on occasion. The salamander larvae must achieve sufficient size in order to successfully capture frog tadpoles, and we examined whether the presence of tadpoles causes development of greater body and/or gape size in newly hatched salamander larvae, which will in turn result in advantageous future prey-predator interactions. To examine this hypothesis, we conducted three laboratory experiments to demonstrate the phenotypic plasticity of salamander hatchlings in response to the presence or absence of frog tadpoles and to screen the type of signals involved in the expression of the phenotypic plasticity. First, salamander hatchlings were reared alone or with tadpoles, and the growth and morphological traits of the hatchlings were compared. The results showed that hatchling larvae grew faster with a more developed gape in the presence of tadpoles. Next, to identify the type of signals inducing this plasticity, two separate experiments with manipulated chemical and visual signals from tadpoles were conducted. The findings showed that faster growth and a more developed gape were induced by chemical but not visual signals. This plasticity may be an adaptive strategy because it increases the likelihood of preying on tadpoles in future prey-predator interactions.


Assuntos
Adaptação Fisiológica , Urodelos/crescimento & desenvolvimento , Animais , Sinais (Psicologia) , Larva/crescimento & desenvolvimento , Larva/fisiologia , Boca/anatomia & histologia , Boca/crescimento & desenvolvimento , Comportamento Predatório , Ranidae , Urodelos/fisiologia , Água/química
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