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1.
Zhongguo Zhong Yao Za Zhi ; 47(17): 4658-4664, 2022 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-36164872

RESUMO

The endophytic fungus Nigrospora sphaerica S5 derived from the semi-mangrove plant Myoporum bontioides was fermented. Its metabolites were purified by column chromatography. Nine compounds were obtained and identified as terezine P(1), 3-(1-hydroxyethyl)-4-methyl dihydrofuran-2(3H)-one(2), methylhydroheptelidate(3), hydroheptelidic acid(4), 5, 7-dimethoxy-4, 6-dimethylphthalide(5),(3R,4S)-(-)-4-hydroxymellein(6), pestalopyrone(7), indole-3-formaldehyde(8) and p-hydroxybenzaldehyde(9) by spectroscopic techniques. Terezine P(1) was a new alkaloid belonging to the terezine class with a pyrazine ring. Compounds 2-7 were lactones, of which 3 and 4 belonged to sesquiterpenes. Compounds 8 and 9 were indole alkaloids and phenols, respectively. Compounds 3-6 were purified from Nigrospora sp. for the first time. These compounds showed different degrees of antibacterial activity against Staphylococcus aureus, Escherichia coli of O6 serotype and E. coli of O78 serotype.


Assuntos
Alcaloides , Ascomicetos , Myoporum , Sesquiterpenos , Antibacterianos/farmacologia , Ascomicetos/química , Escherichia coli , Formaldeído , Indóis/farmacologia , Lactonas , Estrutura Molecular , Myoporum/química , Myoporum/microbiologia , Fenóis , Pirazinas
2.
Nat Prod Res ; 36(22): 5708-5714, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34927497

RESUMO

A new sesquiterpene glucoside (1), two new norsesquiterpenes (2, 3), and a new homomonoterpene (4), named myobontioids A-D respectively, along with twelve known flavonoids and lignans (5-16) were isolated from Myoporum bontioides A. Gray. Flavanones 5-11 specifically inhibited Phytophthora capsici and Magnaoeporthe grisea at the concentrations of 125, 250 and 500 µg.mL-1. Notably, the new compound 4 possessed a strong activity against Phytophthora capsici with IC50 below 63.5 µg.mL-1 and 90.4% inhibition at 125 µg.mL-1.


Assuntos
Myoporum , Phytophthora , Sesquiterpenos , Antifúngicos/farmacologia , Folhas de Planta , Flavonoides/farmacologia , Sesquiterpenos/farmacologia
3.
J Econ Entomol ; 112(4): 1645-1650, 2019 08 03.
Artigo em Inglês | MEDLINE | ID: mdl-30937449

RESUMO

Myoporum spp. (Lamiales: Scrophulariaceae) native to Australia and New Zealand have been introduced into North America and have been widely planted as shrubs and ground covers in the California urban landscape. The invasive thrips, Klambothrips myopori Mound and Morris, invaded California in 2005 and feed exclusively on Myoporum. However, some commercial cultivars have suffered extensive damage, whereas others have not. In field studies and laboratory feeding tests of six different potential host species or cultivars, Myoporum laetum and Myoporum 'Pacificum' were identified as most suitable host plants of K. myopori. In laboratory trials, K. myopori failed to complete development on M. 'Clean n Green' and M. 'Putah Creek'. Of the six varieties of Myoporum tested, K. myopori damage was only observed on M. laetum and M. 'Pacificum'. Although K. myopori can successfully colonize and reproduce on several varieties of Myoporum, they demonstrated a preference for M. laetum and M. 'Pacificum' in laboratory and field trials.


Assuntos
Myoporum , Tisanópteros , Animais , Austrália , California , Nova Zelândia
4.
Mar Drugs ; 17(2)2019 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-30717119

RESUMO

Four new isocoumarin derivatives, botryospyrones A (1), B (2), C (3), and D (4), and a new natural tryptamine, (3aS, 8aS)-1-acetyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo [2,3b] indol-3a-ol (5), were isolated from a marine mangrove endophytic fungus Botryosphaeria ramosa L29, obtained from the leaf of Myoporum bontioides. Their structures were elucidated using spectroscopic analysis. The absolute configurations of compounds 3, 4, and 5 were determined by comparison of their circular dichroism (CD) spectra with the calculated data. The inhibitory activities of compound 1 on Fusarium oxysporum, of compounds 2 and 3 on F. oxysporum and Fusarium graminearum, and of compound 5 on F. oxysporum, Penicillium italicum, and F. graminearum were higher than those of triadimefon, widely used as an agricultural fungicide. Compound 5 was produced after using the strategy we called "using inhibitory stress from components of the host" (UISCH), wherein (2R, 3R)-3, 5, 7-trihydroxyflavanone 3-acetate, a component of M. bontioides with weak growth inhibitory activity towards B. ramosa L29, was introduced into the culture medium.


Assuntos
Antifúngicos/química , Ascomicetos/química , Fusarium/efeitos dos fármacos , Isocumarinas/química , Isocumarinas/farmacologia , Triptaminas/química , Triptaminas/farmacologia , Antifúngicos/farmacologia , Dicroísmo Circular , Endófitos/química , Espectroscopia de Ressonância Magnética , Myoporum , Penicillium/efeitos dos fármacos , Áreas Alagadas
5.
Mar Drugs ; 16(11)2018 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-30413080

RESUMO

The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, which led to the isolation of two new sesquiterpene alkaloids (1 and 2) and six known furanosesquiterpenes (3⁻8). Their structures were elucidated on the basis of extensive analysis of their 1D, 2D NMR and mass spectroscopic data. These two new alkaloids (1 and 2) displayed potent anti-MRSA activity with MIC value of 6.25 µg/mL. This is the first report of sesquiterpene alkaloids from the plants of Myoporum genus and their anti-MRSA activity.


Assuntos
Alcaloides/farmacologia , Antibacterianos/farmacologia , Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos , Myoporum/química , Sesquiterpenos/farmacologia , Alcaloides/química , Alcaloides/isolamento & purificação , Antibacterianos/química , Antibacterianos/isolamento & purificação , Avaliação Pré-Clínica de Medicamentos , Testes de Sensibilidade Microbiana , Estrutura Molecular , Folhas de Planta/química , Sesquiterpenos/química , Sesquiterpenos/isolamento & purificação , Áreas Alagadas
6.
Molecules ; 22(7)2017 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-28708125

RESUMO

Investigation of the single plant source bee glue type originating from Southern Australia resulted in the isolation and structure elucidation of major serrulatane diterpenes, novel 7,8,18-trihydroxyserrulat-14-ene (1), along with its oxidized product, 5,18-epoxyserrulat-14-en-7,8-dione (3) and known (18RS)-5,18-epoxyserrulat-14-en-8,18-diol (2). Exploration into the botanical origin revealed Myoporum insulare R. Br, as the plant source of the bee glue materials. This discovery was made through comparative analysis of the myoporum bee glue samples collected from the beehives, analyses of plant resinous exudate, and resin carried on the hind legs of bees foraging for bee glue.


Assuntos
Diterpenos/química , Plantas/química , Própole/química , Resinas Vegetais/química , Animais , Abelhas , Estrutura Molecular , Myoporum/química , Scrophulariaceae/química
7.
Molecules ; 22(3)2017 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-28294989

RESUMO

Myoporum bontioides is a traditional medicinal plant in Asia with various biological activities, including anti-inflammatory and anti-bacterial characteristics. To identify the bioactive constituents from M. bontioides, a newly-identified flavone, 3,4'-dimethoxy-3',5,7-trihydroxyflavone (compound 1), along with eight known compounds, were investigated in human MCF-7 breast cancer, SCC4 oral cancer, and THP-1 monocytic leukemia cells. Among these compounds, compound 1 exhibited the strongest antiproliferative activity with half-maximal inhibitory concentration (IC50) values ranging from 3.3 µM (MCF-7) to 8.6 µM (SCC4). Flow cytometric analysis indicated that compound 1 induced G2/M cell cycle arrest in MCF-7 cells. Mechanistic evidence suggests that the G2/M arrest could be attributable to compound 1's modulatory effects on the phosphorylation and expression of numerous key signaling effectors, including cell division cycle 2 (CDC2), CDC25C, and p53. Notably, compound 1 downregulated the expression of histone deacetylase 2 (HDAC2) and HDAC4, leading to increased histone H3 acetylation and p21 upregulation. Together, these findings suggest the translational potential of compound 1 as a breast cancer treatment.


Assuntos
Neoplasias da Mama/metabolismo , Flavonas/farmacologia , Pontos de Checagem da Fase M do Ciclo Celular , Myoporum/química , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/patologia , Ciclo Celular/efeitos dos fármacos , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Ensaios de Seleção de Medicamentos Antitumorais , Feminino , Flavonas/química , Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos , Humanos , Células MCF-7 , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Transdução de Sinais/efeitos dos fármacos
8.
Zootaxa ; 4073(1): 1-84, 2016 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-27395952

RESUMO

The Triozidae is a diverse, cosmopolitan family of jumping plant-lice (Hemiptera: Psylloidea) from an exceptionally diverse range of plant families, but with few described Australian species. As a direct outcome of the Australian Biological Resources Study Bush Blitz species discovery program, many new Psylloidea from novel host plants in remote localities have been revealed. In this study a new genus Myotrioza Taylor gen. nov. and 20 new species are described from southern and central Australia which also establishes the first host plant records from Eremophila and Myoporum (Scrophulariaceae: Myoporeae). New species, delineated using a combination of morphological and mitochondrial COI sequence data, are: Myotrioza clementsiana sp. nov., M. darwinensis sp. nov., M. desertorum sp. nov., M. eremi sp. nov., M. eremophili sp. nov., M. flindersiana sp.nov., M. gawlerensis sp. nov., M. insularis sp. nov., M. interioris sp. nov., M. interstantis sp. nov., M. longifoliae sp. nov., M. markmitchelli sp. nov., M. myopori sp. nov., M. oppositifoliae sp. nov., M. pantonii sp. nov., M. platycarpi sp. nov., M. remota sp. nov., M. scopariae sp. nov., M. serrulatae sp. nov., and M. telowiensis sp. nov. Genetic divergence data, host associations, biogeographic data, diagnoses and a key to species are presented. Myotrioza appears to be particularly diverse in ephemeral southern Australia, especially in inland Western Australia and South Australia, matching regions of high diversity of the host genera; some species are likely to be short range endemics.


Assuntos
Afídeos/classificação , Eremophila (Planta)/parasitologia , Myoporum/parasitologia , Distribuição Animal , Estruturas Animais/anatomia & histologia , Estruturas Animais/crescimento & desenvolvimento , Animais , Afídeos/anatomia & histologia , Afídeos/genética , Afídeos/crescimento & desenvolvimento , Tamanho Corporal , Ecossistema , Feminino , Masculino , Tamanho do Órgão , Filogenia
9.
Mar Drugs ; 13(7): 4492-504, 2015 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-26204946

RESUMO

Racemic new cyclohexenone and cyclopentenone derivatives, (±)-(4R*,5S*,6S*)-3-amino-4,5,6-trihydroxy-2-methoxy-5-methyl-2-cyclohexen-1-one (1) and (±)-(4S*,5S*)-2,4,5-trihydroxy-3-methoxy-4-methoxycarbonyl-5-methyl-2-cyclopenten-1-one (2), and two new xanthone derivatives 4-chloro-1,5-dihydroxy-3-hydroxymethyl-6-methoxycarbonyl-xanthen-9-one (3) and 2,8-dimethoxy-1,6-dimethoxycarbonyl-xanthen-9-one (4), along with one known compound, fischexanthone (5), were isolated from the culture of the mangrove endophytic fungus Alternaria sp. R6. The structures of these compounds were elucidated by analysis of their MS (Mass), one and two dimensional NMR (nuclear magnetic resonance) spectroscopic data. Compounds 1 and 2 exhibited potent ABTS [2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)] scavenging activities with EC50 values of 8.19 ± 0.15 and 16.09 ± 0.01 µM, respectively. In comparison to Triadimefon, compounds 2 and 3 exhibited inhibitory activities against Fusarium graminearum with minimal inhibitory concentration (MIC) values of 215.52 and 107.14 µM, respectively, and compound 3 exhibited antifungal activity against Calletotrichum musae with MIC value of 214.29 µM.


Assuntos
Alternaria/química , Antifúngicos/isolamento & purificação , Antifúngicos/farmacologia , Fusarium/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Testes de Sensibilidade Microbiana , Myoporum/microbiologia , Phyllachorales/efeitos dos fármacos
10.
Mar Drugs ; 12(5): 2840-50, 2014 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-24828291

RESUMO

Three new resveratrol derivatives, namely, resveratrodehydes A-C (1-3), were isolated from the mangrove endophytic fungus Alternaria sp. R6. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. All compounds showed broad-spectrum inhibitory activities against three human cancer cell lines including human breast MDA-MB-435, human liver HepG2, and human colon HCT-116 by MTT assay (IC50 < 50 µM). Among them, compounds 1 and 2 both exhibited marked cytotoxic activities against MDA-MB-435 and HCT-116 cell lines (IC50 < 10 µM). Additionally, compounds 1 and 3 showed moderate antioxidant activity by DPPH radical scavenging assay.


Assuntos
Alternaria/química , Antioxidantes/química , Estilbenos/química , Alternaria/metabolismo , Antibióticos Antineoplásicos/biossíntese , Antibióticos Antineoplásicos/química , Antibióticos Antineoplásicos/farmacologia , Linhagem Celular Tumoral , Fermentação , Sequestradores de Radicais Livres/química , Sequestradores de Radicais Livres/farmacologia , Humanos , Myoporum/microbiologia , Resveratrol
11.
Mar Pollut Bull ; 85(2): 738-46, 2014 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-24768170

RESUMO

The effect of different concentrations of NaCl, 0, 100, 200, 300 and 400 mM, on the anatomical features and physiology of Myoporum bontioides was investigated. The photosynthetic rates (Pn) were significantly reduced by salt stress, with the lowest values at 400 mM NaCl. The content of malondialdehyde (MDA), proline and soluble sugar, as well as the activities of peroxidase (POD) and catalase (CAT) increased at the beginning, but became similar to the control as the experiment proceeded. The NaCl effect on superoxide dismutase (SOD) was different from the other parameters, with a significant reduction at 400 mM NaCl at Day 7. Salt glands were found in both upper and lower epidermis, and the ratios of the thickness of palisade to spongy mesophyll tissues increased with NaCl concentrations. The medullary ray was clearly damaged by NaCl at levels of 200 and 300 mM. These results demonstrated that M. bontioides could adapt to a relatively low salinity, and was not a halophilous species.


Assuntos
Antioxidantes/análise , Myoporum/fisiologia , Folhas de Planta/efeitos dos fármacos , Cloreto de Sódio/química , Catalase/metabolismo , China , Estuários , Água Doce , Malondialdeído/química , Myoporum/anatomia & histologia , Osmose/efeitos dos fármacos , Peroxidase/metabolismo , Fotossíntese/efeitos dos fármacos , Caules de Planta/efeitos dos fármacos , Prolina/química , Salinidade , Superóxido Dismutase/metabolismo
12.
J Asian Nat Prod Res ; 15(2): 209-14, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23323861

RESUMO

A new di-O-prenylated flavone, named 7,3'-di-(γ,γ-dimethylallyloxy)-5-hydroxy-4'-methoxyflavone (1), was isolated from the culture broth of the endophytic actinomycete Streptomyces sp. MA-12 isolated from the root of the semi-mangrove plant Myoporum bontioides A. Gray. The structure of 1 was determined by comprehensive spectroscopic methods, including 1D and 2D NMR experiments (COSY, HMQC, and HMBC). Primary bioassays showed that 1 at concentration of 0.25 mM had moderate inhibitory activity against three plant pathogenic fungi including Colletotrichum musae, Gibberella zeae (Schweinitz) Petch, and Penicillium citrinum Thom.


Assuntos
Antifúngicos/isolamento & purificação , Flavonas/isolamento & purificação , Myoporum/microbiologia , Streptomyces/química , Antifúngicos/química , Antifúngicos/farmacologia , Flavonas/química , Flavonas/farmacologia , Testes de Sensibilidade Microbiana , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Raízes de Plantas/microbiologia
13.
Int J Syst Evol Microbiol ; 62(Pt 5): 1215-1219, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-21828013

RESUMO

Citeromyces hawaiiensis sp. nov. (NRRL Y-11581(T)  = CBS 12303(T), type strain) is described from 12 strains isolated from flux of the sandalwood (Myoporum sandwicense) and adjacent soil in Hawaii, USA. Analyses of gene sequences from the D1/D2 domains of nuclear large subunit rRNA, internal transcribed spacer (ITS), mitochondrial small-subunit rRNA and translation elongation factor-1α each separated the proposed novel species from Citeromyces matritensis and Citeromyces siamensis, the other known species of the genus Citeromyces. The three species are morphologically similar but they can be separated by growth reactions in standard assimilation tests. An additional strain of Citeromyces siamensis (NRRL Y-11788), a species previously known only from Thailand, was obtained from spoiled condensed milk in Ohio, USA.


Assuntos
Myoporum/microbiologia , Saccharomycetales/classificação , Saccharomycetales/isolamento & purificação , Microbiologia do Solo , Análise por Conglomerados , DNA Fúngico/química , DNA Fúngico/genética , DNA Ribossômico/química , DNA Ribossômico/genética , DNA Espaçador Ribossômico/química , DNA Espaçador Ribossômico/genética , Genes de RNAr , Hawaii , Dados de Sequência Molecular , Técnicas de Tipagem Micológica , Fator 1 de Elongação de Peptídeos/genética , Filogenia , RNA Fúngico/genética , RNA Ribossômico/genética , RNA Ribossômico 16S/genética , Saccharomycetales/genética , Saccharomycetales/metabolismo , Análise de Sequência de DNA
14.
Phytochemistry ; 69(13): 2517-22, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-18755483

RESUMO

Sixteen compounds were isolated from the MeOH extract of leaves of Myoporum bontioides. The five compounds hitherto unknown, were elucidated to be a chlorine-containing iridoid, named myopochlorin, and an iridoid glucoside, an acylated iridoid glucoside, a linear acetogenin glucoside, and an acyclic monoterpene glucoside, named myobontiosides A-D, respectively, by means of spectroscopic analyses.


Assuntos
Cloro/química , Glucosídeos/química , Iridoides/química , Myoporum/química , Folhas de Planta/química , Cromatografia Líquida de Alta Pressão , Glucosídeos/isolamento & purificação , Iridoides/isolamento & purificação , Espectrometria de Massas , Estrutura Molecular
15.
Pest Manag Sci ; 64(2): 203-7, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18069657

RESUMO

BACKGROUND: In order to understand the bioactivity of Myoporum bontioides A. Gray against plant pathogens and determine its active ingredients, the inhibitory activities of methanol extracts from M. bontioides against Fusarium oxysporum f. sp. niveum (E. F. Smith) Snyder & Hansen, Pestalotia mangiferae P. Henn., Thielaviopsis paradoxa (De Seynes) v. Hohnel, Colletotrichum musae (Berk. & M. A. Curtis) v. Arx, Alternaria alternata (Fr.) Keissler, Mycosphaerella sentina (Fr.) Schroter and Sphaceloma fawcettii Jenk. were evaluated using a growth rate method, and the active ingredient was isolated by activity-directed isolation and identified by determination and analysis of IR, (1)H NMR, (13)C NMR and mass spectra and correlative physical constants. RESULTS: The results showed that the extracts from stems and leaves of M. bontioides exhibited inhibitory activity against the seven fungi, with > 58% inhibition at 10 g L(-1) after 72 h. The active compound was isolated and identified as (-)-epingaione, and showed inhibitory activity against the above seven fungi. The inhibitory activity against P. mangiferae was the highest, with an EC(50) value of 77 mg L(-1). The EC(50) values against the other six fungi were 147-245 mg L(-1). (-)-Epingaione also inhibited spore germination of F. oxysporum f. sp. niveum, T. paradoxa and S. fawcettii. CONCLUSION: (-)-Epingaione demonstrated broad-spectrum inhibitory activity against plant pathogenic fungi and is promising for exploitation as a fungicide.


Assuntos
Fungos/efeitos dos fármacos , Furanos/química , Furanos/farmacologia , Myoporum/química , Pentanonas/química , Pentanonas/farmacologia , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Fungicidas Industriais/química , Fungicidas Industriais/farmacologia , Estrutura Molecular
16.
Ying Yong Sheng Tai Xue Bao ; 15(7): 1171-3, 2004 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-15506092

RESUMO

The bioactivity of Myoporum bontioides extracts to Plutella xylostella was studied with IIPC as evaluated index. The results showed that petroleum ether and chloroform extracts had a higher activity than ethyl acetate and alcohol extracts. At 0.01 gDW x ml(-1), the ODR of petroleum ether and chloroform extracts was 84.69% and 79.90%, and 76.47% and 45.70% after treated 1d and 3d, while the IIPC was 0.1565 and 0.2055, respectively. Provided with a higher concentration of 0.05 gDW x ml(-1), the ODR was 88.52% and 72.25%, and 87.33%, 58.37%, while the IIPC was 0.1125 and 0.2620, respectively. From the chloroform extract of Myopdrum Bontioides, three flavonoids, 2, 3-dihydro-5, 7-dihydroxy-2-phenyl-4H-1-Benzopyran-4-one (I), 3, 5, 7-trihydroxy-2-phenyl-4H-1-Benzopyran-4-one (II) and 5, 7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4H-1-Benzopyran-4-one (III), were isolated, and their structure were identified based on the analyses of physical and spectrum data. Among these compounds, (II) had a better bioactivity to Plutella xylostella.


Assuntos
Flavonoides/farmacologia , Controle de Insetos , Mariposas/crescimento & desenvolvimento , Myoporum/química , Animais , Flavonoides/isolamento & purificação , Extratos Vegetais/farmacologia
17.
Ying Yong Sheng Tai Xue Bao ; 15(1): 149-52, 2004 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-15139209

RESUMO

This study showed that the volatile oils from Myoporum bontioides had a significant repellent action on Plutella xylostella. When Plutella xylostella adults entered into the 4-arm selective olfactometer, the preferred times and average staying duration, in the order from more to less, were 3, 1, 4, and 2 arms, which showed a tendency of keeping away from the treatment arms. The males were more sensitive to the volatile oils than the females, when the velocity of flow was 200 ml.min-1. On the first day of the 3rd bioassay, the oviposition deterrent rate and IIPC of the volatile oils on Plutella xylostella adults was 94.48% and 0.0552, respectively. A liquid component of the volatile oils from Myoporum bontioides was isolated, purified, and identified as myoporone.


Assuntos
Mariposas , Myoporum/química , Óleos Voláteis/farmacologia , Controle Biológico de Vetores , Animais , Feminino , Masculino
18.
Pesqui. vet. bras ; 23(4): 149-155, out.-dez. 2003. ilus
Artigo em Português | LILACS | ID: lil-354288

RESUMO

Amostras de Myoporum laetum foram colhidas durante a primavera e verão e administradas a cinco ovinos e seis bovinos em doses únicas de 20 e 30 g/kg. Biópsias hepáticas foram colhidas antes (controles) e 1, 3 e 7 dias após a dosagem da planta. Estas biópsias foram analisadas histológica e ultra-estruturalmente. Os sinais clínicos, em ovinos, caracterizaram-se, especialmente, por depressão, diminuição dos movimentos ruminais, fezes ressequidas, tenesmo, ranger de dentes, dispnéia e lesões típicas de fotossensibilização. Em bovinos, o quadro clínico foi discreto. Os principais achados histológicos, em ovinos, incluíram vacuolização de hepatócitos, fibrose portal, proliferação de ductos biliares e necrose de hepatócitos periportais. Os estudos ultra-estruturais, em ovinos, revelaram hiperplasia do retículo endoplasmático liso, tumefação de hepatócitos, degranulação e vesiculação do retículo endoplasmático rugoso, presença de cristais aciculares, retenção biliar, tumefação de mitocôndrias e várias outras alterações degenerativas. Em bovinos, tanto os achados histológicos, quanto os ultra-estruturais foram menos evidentes


Assuntos
Animais , Bovinos , Myoporum , Intoxicação por Plantas , Plantas Tóxicas , Ovinos
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