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1.
Sci Rep ; 12(1): 13497, 2022 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-35931730

RESUMO

Boosting of thermal transportation is the demand of current era. Several techniques have been used to do so. One of an important way is the mixing of nanoparticles to boost thermal performance. Current investigation has been prepared to study the inclusion of tri hybrid nanoparticles in Prandtl fluid model past over a stretched heated sheet. Modelling of consider problem has been done due to consideration of movement in flow in Cartesian coordinates which results coupled partial differential equation system thermal transport in presented by considering generalized heat flux model and heat generation/absorption. The derived coupled complex partial differential equations (PDEs) system is simplified by engaging boundary layer theory. Such developed model is used in coolants regarding automobiles, dynamics in fuel and production of solar energy, fuel cells, optical chemical sensors, automotive parts, dental products, cancer therapy, electrical insulators and dental products. Handling of complex PDEs for the solution is a challenging task. Due to complexity in computational work these PDEs have been transformed into ordinary differential equations (ODEs) after applying similarity transformation afterwards converted ODEs have been approximated via finite element algorithm coded in MAPLE 18.0 symbolic computational package. Comparative study has been presented for the validity of code and authenticity of obtained result. It is observed that fluid velocity for tri-hybrid nanoparticles is higher than fluidic motion for pure fluid, nanofluid and hybrid nanomaterial.


Assuntos
Nanopartículas , Nanoestruturas , Análise de Elementos Finitos , Modelos Teóricos , Movimento (Física)
2.
Anal Chim Acta ; 1221: 340101, 2022 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-35934347

RESUMO

With the aid of good biocompatibility and stability with hydroxyapatite (HAp) in protein separation and adsorption fields, we developed a novel extraction-isolation albumin analysis method by relying on the specific adsorption capacity of HAp, combining with surface-enhanced Raman spectroscopy (SERS) for prostate cancer screening. Two different nanostructures of HAp particles, including the HAp flower and HAp sphere, were synthesized with a hydrothermal method, and the targeted binding and extraction abilities of serum albumin of these two HAp particles were compared. By changing the morphology of the nanostructure, the albumin-adsorption capacity of HAp varied significantly. Compared with spherical HAp particles, HAp flower particles have more albumin binding sites per unit area. Thus, the HAp flower displayed the superior capacity for adsorption-release of albumin, which was further employed for clinical prostate cancer screening. Based on the superior adsorption-extraction ability of albumin of HAp flower, serum albumin was adsorbed and extracted by HAp flower from serum samples of prostate cancer patients (n = 30) and healthy volunteers (n = 30), and mixed with silver colloids to perform SERS spectral analysis. The partial least square-support vector machines (PLS-SVM) model is used to analyze the obtained serum albumin SERS spectra and establish the diagnostic model, the diagnostic accuracy was up to 95.00% for differentiating the normal volunteer from prostate patient groups. The results demonstrate that the PLS-SVM model provides superior performance in the classification of a prostate cancer diagnosis. Due to the advantages of simplicity and rapidness, the HAp flower-adsorbed-released albumin combined with SERS was expected to become a promising tool for prostate cancer detection.


Assuntos
Nanoestruturas , Neoplasias da Próstata , Durapatita/química , Detecção Precoce de Câncer , Humanos , Masculino , Próstata , Antígeno Prostático Específico , Neoplasias da Próstata/diagnóstico , Albumina Sérica , Análise Espectral Raman/métodos
3.
Biomater Adv ; 136: 212797, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35929296

RESUMO

Since the discovery that nanostructured surfaces were able to kill bacteria, many works have been published focusing on the design of nanopatterned surfaces with antimicrobial properties. Synthetic bone grafts, based on calcium phosphate (CaP) formulations, can greatly benefit from this discovery if adequate nanotopographies can be developed. However, CaP are reactive materials and experience ionic exchanges when placed into aqueous solutions which may in turn affect cell behaviour and complicate the interpretation of the bactericidal results. The present study explores the bactericidal potential of two nanopillared CaP prepared by hydrolysis of two different sizes of α-tricalcium phosphate (α-TCP) powders under biomimetic or hydrothermal conditions. A more lethal bactericidal response toward Pseudomonas aeruginosa (~75% killing efficiency of adhered bacteria) was obtained from the hydrothermally treated CaP which consisted in a more irregular topography in terms of pillar size (radius: 20-60 nm), interpillar distances (100-1500 nm) and pillar distribution (pillar groups forming bouquets) than the biomimetically treated one (radius: 20-40 nm and interpillar distances: 50-200 nm with a homogeneous pillar distribution). The material reactivity was greatly influenced by the type of medium (nutrient-rich versus nutrient-free) and the presence or not of bacteria. A lower reactivity and superior bacterial attachment were observed in the nutrient-free medium while a lower attachment was observed for the nutrient rich medium which was explained by a superior reactivity of the material paired with the lower tendency of planktonic bacteria to adhere on surfaces in the presence of nutrients. Importantly, the ionic exchanges produced by the presence of materials were not toxic to planktonic cells. Thus, we can conclude that topography was the main contributor to mortality in the bacterial adhesion tests.


Assuntos
Biomimética , Nanoestruturas , Antibacterianos/farmacologia , Aderência Bacteriana , Fosfatos de Cálcio/farmacologia
4.
Sci Rep ; 12(1): 13408, 2022 Aug 04.
Artigo em Inglês | MEDLINE | ID: mdl-35927565

RESUMO

Composites of polymer and graphene-based nanomaterials (GBNs) combine easy processing onto porous 3D membrane geometries due to the polymer and cellular differentiation stimuli due to GBNs fillers. Aiming to step forward to the clinical application of polymer/GBNs composites, this study performs a systematic and detailed comparative analysis of the influence of the properties of four different GBNs: (i) graphene oxide obtained from graphite chemically processes (GO); (ii) reduced graphene oxide (rGO); (iii) multilayered graphene produced by mechanical exfoliation method (Gmec); and (iv) low-oxidized graphene via anodic exfoliation (Ganodic); dispersed in polycaprolactone (PCL) porous membranes to induce astrocytic differentiation. PCL/GBN flat membranes were fabricated by phase inversion technique and broadly characterized in morphology and topography, chemical structure, hydrophilicity, protein adsorption, and electrical properties. Cellular assays with rat C6 glioma cells, as model for cell-specific astrocytes, were performed. Remarkably, low GBN loading (0.67 wt%) caused an important difference in the response of the C6 differentiation among PCL/GBN membranes. PCL/rGO and PCL/GO membranes presented the highest biomolecule markers for astrocyte differentiation. Our results pointed to the chemical structural defects in rGO and GO nanomaterials and the protein adsorption mechanisms as the most plausible cause conferring distinctive properties to PCL/GBN membranes for the promotion of astrocytic differentiation. Overall, our systematic comparative study provides generalizable conclusions and new evidences to discern the role of GBNs features for future research on 3D PCL/graphene composite hollow fiber membranes for in vitro neural models.


Assuntos
Grafite , Nanoestruturas , Animais , Grafite/química , Poliésteres/química , Polímeros , Ratos
5.
Front Public Health ; 10: 904544, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35910929

RESUMO

As with toxicology in general, major challenges have emerged in its subfield neurotoxicology regarding the testing of engineered nanomaterials (ENM). This is on the one hand due to their complex physicochemical properties, like size, specific surface area, chemical composition as well as agglomeration and dissolution behavior in biological environments. On the other hand, toxicological risk assessment has faced an increasing demand for the development and implementation of non-animal alternative approaches. Regarding the investigation and interpretation of the potential adverse effects of ENM on the brain, toxicokinetic data are relatively scarce and thus hampers dose selection for in vitro neurotoxicity testing. Moreover, recent in vivo studies indicate that ENM can induce neurotoxic and behavioral effects in an indirect manner, depending on their physicochemical properties and route of exposure. Such indirect effects on the brain may proceed through the activation and spill-over of inflammatory mediators by ENM in the respiratory tract and other peripheral organs as well via ENM induced disturbance of the gut microbiome and intestinal mucus barrier. These ENM specific aspects should be incorporated into the ongoing developments of advanced in vitro neurotoxicity testing methods and strategies.


Assuntos
Microbioma Gastrointestinal , Nanoestruturas , Nanoestruturas/toxicidade , Medição de Risco
6.
Biomater Adv ; 139: 213040, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35914429

RESUMO

Curcumin (Cur) plays a key role in photodynamic antibacterial activity as a photosensitizer. On the other hand, the antimicrobial potential of graphene oxide (GO) has been reported controversially, and how to improve its antimicrobial ability has become an meaningful study. In this study, we prepared polydopamine-curcumin (PDA-Cur) by pi-pi stacking and loaded it onto the GO surface to obtain GO/PDA-Cur composite nanomaterials. GO/PDA-Cur was characterized by physical and optical means, and GO/PDA-Cur possessed good dispersion and stability in water. In vitro antibacterial results showed that GO/PDA-Cur mediated photodynamic therapy significantly reduced Gram-positive Staphylococcus aureus (S. aureus) by 4 orders of magnitude with a bactericidal rate of 99.99 %. The antibacterial mechanism stems from the fact that GO/PDA-Cur can generate reactive oxygen species (ROS) under white light irradiation (405-780 nm), which causes bacterial outer membrane breakage and cellular deformation. In addition, GO/PDA-Cur has good biocompatibility. The antibacterial ability of graphene oxide was significantly improved by combining it with PDA-Cur, which allows it to be used as a photodynamic antibacterial material.


Assuntos
Curcumina , Nanoestruturas , Antibacterianos/farmacologia , Curcumina/farmacologia , Grafite , Indóis , Polímeros , Staphylococcus aureus
7.
Adv Food Nutr Res ; 101: 237-275, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35940707

RESUMO

Bioactive compounds in foods, nutraceuticals and pharmaceutical have been gaining interest due to health benefits, which can help to reduce the risk of certain chronic diseases. Recently, nanoencapsulation have attract attention because it is an efficient and promising approach for protection of bioactive compounds, and delivery them to the target physiological sites for controlled release and improvement absorption. Food proteins are promising materials to be fabricated into a variety of nanostructured delivery systems because of their high nutritional value, good functional properties, and health-benefiting effects. Various techniques and approaches are utilized to prepare nanostructured food protein. This chapter introduces the major techniques for the fabrication of nanoparticles and nanoemulsions from food proteins. The basic principles, advantages, and limitations of the techniques are discussed. The encapsulation and release of bioactive compounds in different nanostructured food proteins are illustrated in specific case studies. Due to the fast growing interest of bioactive encapsulation in various sectors, this chapter is of importance for guiding the development of nanostructured food protein loaded with bioactive ingredients for food, nutraceutical and pharmaceutical applications.


Assuntos
Nanopartículas , Nanoestruturas , Suplementos Nutricionais , Preparações Farmacêuticas
8.
Methods Mol Biol ; 2516: 157-167, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35922627

RESUMO

Direct, live imaging of protein-DNA interactions under physiological conditions is invaluable for understanding the mechanism and kinetics of binding and understanding the topological changes of the DNA strand. The DNA origami technology allows for precise placement of target molecules in a designed nanostructure. Here, we describe a protocol for the self-assembly of DNA origami frames with 2 stretched DNA sequences containing the binding site of a transcription factor, i.e., the Protein FadR, which is a TetR-family tanscription factor regulator for fatty acid metabolism in the archaeal organism Sulfolobus acidocaldarius. These frames can be used to study the dynamics of transcription factor binding using high-speed AFM and obtain mechanistic insights into the mechanism of action of transcription factors.


Assuntos
DNA , Nanoestruturas , DNA/química , Microscopia de Força Atômica/métodos , Nanoestruturas/química , Nanotecnologia/métodos , Conformação de Ácido Nucleico , Fatores de Transcrição
9.
Chempluschem ; 87(8): e202200127, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35914775

RESUMO

Numerous nucleic acid nanostructures of unique addressability and programmability have been fabricated for emerging applications. Structural characterization with atomic force microscopy and electron microscopy can provide information on the structural morphology and precision of these nanostructures. However, either structural information of native nucleic acid nanostructures in hydrated environment or the availability of addressable sites on these nanostructures could not be determined. Alternatively, DNA points accumulation for imaging in nanoscale topography (DNA-PAINT) enables direct optical visualization of nucleic acid nanostructures in native forms, as well as evaluation of the accessibility of addressable sites on them. In this Review, the working principle of DNA-PAINT is introduced, followed by the summary on advances of DNA-PAINT characterization of various nucleic acid nanostructures. Finally, the current challenges and prospects for DNA-PAINT characterization are presented. We envision DNA-PAINT to be a potent characterization tool for functional nanomaterials.


Assuntos
Nanoestruturas , Ácidos Nucleicos , DNA/química , Microscopia de Fluorescência/métodos , Nanoestruturas/química , Nanotecnologia/métodos
10.
Drug Deliv ; 29(1): 2579-2591, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35915055

RESUMO

Benign prostatic hyperplasia (BPH) is a nonmalignant growth of the prostate tissue and causes urinary tract symptoms. To provide effective treatment, tamsulosin (TM), saw palmetto oil (SP), and pumpkin seed oil (PSO) were combined and fabricated a nanostructured lipid carrier (NLC) as TM-S/P-NLC using experimental design. The purpose was to enhance the permeation and therapeutic activity of TM; combining TM with SP and PSO in an NLC generates a synergistic activity. An optimized TM-S/P-NLC was obtained after statistical analysis, and it had a particle size, percentage of entrapment efficiency, and steady-state flux of 102 nm, 65%, and 4.5 µg/cm2.min, respectively. Additionally, the optimized TM-S/P-NLC had spherical particles with a more or less uniform size and a stability score of 95%, indicating a high level of stability. The in vitro release studies exhibited the optimized TM-S/P-NLC had the maximum release profile for TM (81 ± 4%) as compared to the TM-NLCs prepared without the addition of S/P oil (59 ± 3%) or the TM aqueous suspension (30 ± 5%). The plasma TM concentration-time profile for the TM-S/P-NLC and the marketed TM tablets indicated that when TM was supplied in a TM-S/P-NLC, the pharmacokinetic profile of the drug was improved. Simultaneously, in vivo therapeutic efficacy studies also showed favorable results for the TM-S/P-NLC in terms of the prostate weight and prostate index following treatment of BPH. Based on the findings of present study, we suggest that in the future, the TM-S/P-NLC could be a novel drug delivery system for treating BPH.


Assuntos
Cucurbita , Nanoestruturas , Hiperplasia Prostática , Portadores de Fármacos/farmacocinética , Excipientes , Humanos , Lipídeos , Masculino , Tamanho da Partícula , Extratos Vegetais , Óleos Vegetais , Hiperplasia Prostática/tratamento farmacológico , Serenoa , Tansulosina/uso terapêutico
11.
Biomater Adv ; 135: 212735, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35929201

RESUMO

Developing multifunctional nanostructures that promote bone repair while fighting infection is highly desirable in bone regenerative therapies. Previous efforts have focused on achieving one property or another by altering the chemical makeup of nanostructures or using growth factors or antibiotics. We present nanostructures with several simultaneous functional attributes including positive effects of strontium on bone formation and prevention of osteoclast differentiation along with incorporation of antimicrobial peptides (AMP) to prevent infection. To form these multifunctional nanostructures, mesoporous calcium silicate (CaMSN) was modified with high levels of strontium. For this, CaMSNs were either partially substituted (20 wt% Ca) or completely replaced with strontium (Sr) to form Sr-CaMSN or SrMSN. The mesoporous nature of these bioactive silicate nanostructures rendered a configuration for substantial AMP loading as well as their effective delivery. The physico-chemical and structural characterization of synthesized MSNs confirmed the mesoporous nature of the synthesized MSNs and their total surface area, pore size, pore volume and SBF-mediated bioactivity remained unaltered with the incorporation of Sr. However, biological evaluation confirmed that synthesized SrMSN upregulated osteogenic differentiation of mesenchymal stromal cells and significantly downregulated osteoclast differentiation. Also, the AMP-loaded MSNs prevented formation and growth of methicillin resistant Staphylococcus aureus (MRSA) biofilms. Thus, high Sr-containing AMP-loaded SrMSNs may combat MRSA-associated infection while promoting bone regeneration. The controlled availability of therapeutic Sr and AMP release as SrMSN degrade enables its potential application in bone tissue regeneration.


Assuntos
Anti-Infecciosos , Staphylococcus aureus Resistente à Meticilina , Nanoestruturas , Monofosfato de Adenosina/farmacologia , Anti-Infecciosos/farmacologia , Nanoestruturas/uso terapêutico , Osteogênese , Peptídeos/farmacologia , Silicatos/farmacologia , Estrôncio/farmacologia
12.
Biomater Adv ; 135: 212725, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35929205

RESUMO

The increasing cancer morbidity and mortality requires the development of high-efficiency and low-toxicity anticancer approaches. In recent years, photodynamic therapy (PDT) has attracted much attention in cancer therapy due to its non-invasive features and low side effects. Photosensitizer (PS) is one of the key factors of PDT, and its successful delivery largely determines the outcome of PDT. Although a few PS molecules have been approved for clinical use, PDT is still limited by the low stability and poor tumor targeting capacity of PSs. Various nanomaterial systems have shown great potentials in improving PDT, such as metal nanoparticles, graphene-based nanomaterials, liposomes, ROS-sensitive nanocarriers and supramolecular nanomaterials. The small molecular PSs can be loaded in functional nanomaterials to enhance the PS stability and tumor targeted delivery, and some functionalized nanomaterials themselves can be directly used as PSs. Herein, we aim to provide a comprehensive understanding of PDT, and summarize the recent progress of nanomaterials-based PSs and delivery systems in anticancer PDT. In addition, the concerns of nanomaterials-based PDT including low tumor targeting capacity, limited light penetration, hypoxia and nonspecific protein corona formation are discussed. The possible solutions to these concerns are also discussed.


Assuntos
Nanoestruturas , Neoplasias , Fotoquimioterapia , Humanos , Lipossomos/uso terapêutico , Nanoestruturas/uso terapêutico , Neoplasias/tratamento farmacológico , Fármacos Fotossensibilizantes/uso terapêutico
13.
J Appl Biomater Funct Mater ; 20: 22808000221114708, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35938572

RESUMO

Gold-based metal nanoparticles serve a key role in diagnosing and treating important illnesses such as cancer and infectious diseases. In consideration of this, the current work develops a mathematical model for viscoelastic nanofluid flow in the peristaltic microchannel. Nanofluid is considered as blood-based fluid suspended with gold nanoparticles. In the investigated geometry, various parametric effects such as Joule heating, magnetohydrodynamics, electroosmosis, and thermal radiation have been imposed. The governing equations of the model are analytically solved by using the lubrication theory where the wavelength of the channel is considered large and viscous force is considered more dominant as compared to the inertia force relating the applications in biological transport phenomena. The graphical findings for relevant parameters of interest are given. In the current analysis, the ranges of the parameters have been considered as: 0<κ<6,0<λ1<0.6,2

Assuntos
Nanopartículas Metálicas , Nanoestruturas , Simulação por Computador , Ouro , Modelos Teóricos
14.
Nature ; 608(7922): S2-S3, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35948724

Assuntos
Nanoestruturas
15.
Chem Rev ; 122(13): 11169-11171, 2022 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-35822299
16.
Biosensors (Basel) ; 12(8)2022 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-35892464

RESUMO

Biosensors are powerful analytical tools used to identify and detect target molecules. Electrochemical biosensors, which combine biosensing with electrochemical analysis techniques, are efficient analytical instruments that translate concentration signals into electrical signals, enabling the quantitative and qualitative analysis of target molecules. Electrochemical biosensors have been widely used in various fields of detection and analysis due to their high sensitivity, superior selectivity, quick reaction time, and inexpensive cost. However, the signal changes caused by interactions between a biological probe and a target molecule are very weak and difficult to capture directly by using detection instruments. Therefore, various signal amplification strategies have been proposed and developed to increase the accuracy and sensitivity of detection systems. This review serves as a reference for biosensor and detector research, as it introduces the research progress of electrochemical signal amplification strategies in olfactory and taste evaluation. It also discusses the latest signal amplification strategies currently being employed in electrochemical biosensors for nanomaterial development, enzyme labeling, and nucleic acid amplification techniques, and highlights the most recent work in using cell tissues as biosensitive elements.


Assuntos
Técnicas Biossensoriais , Nanoestruturas , Técnicas Biossensoriais/métodos , Técnicas Eletroquímicas/métodos , Técnicas de Amplificação de Ácido Nucleico/métodos , Paladar
17.
Small ; 18(30): e2202002, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35775952

RESUMO

The protein corona effect has long been treated as the evil source behind delivery efficacy issues. In this study, this concept is challenged by showcasing that the protein corona can serve as a versatile functionalization approach to improve the delivery efficacy or mitigate nanocytotoxicity. To this end, the depleted serum is introduced to create nanomaterials carrying functionally distinct protein corona, referred to as PCylated nanomaterials. It is confirmed that the passivation with depleted serum helps reduce the toxicity and pro-inflammatory response. Furthermore, the same method can be leveraged to enhance the capacity of nanomaterials to undergo endocytosis as well as their potential as an agonist for the NF-κB pathways. The comparable stability of protein corona created by late and early-stage serum reveals that the chanceless interaction with nanomaterials, rather than an inadequate binding strength, may be behind the failure of enriching certain components. The PCylation strategy is extended to cancer patient-derived fluid, creating a set of T1 and T3-stage cancer-specific nanotherapeutics to retard the metastasis of cancer cells, while leaving normal endothelial negligibly affected. It is hoped the novel PCylation approach validated here can shed light on the future development of precision nanomedicine with improved delivery efficacy.


Assuntos
Nanoestruturas , Coroa de Proteína , Endocitose , Humanos , Nanomedicina/métodos , Coroa de Proteína/metabolismo , Proteínas
18.
Chem Commun (Camb) ; 58(60): 8352-8355, 2022 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-35792065

RESUMO

Herein we utilized the thermal hysteresis method to directly probe the self-assembly process of amphiphilic DNA nanostructures, with the use of an amphiphilic tetrahedral DNA framework (am-TDF) as a model system. The analysis of the reaction rate surfaces under different ionic strengths revealed that strands of amphiphilic DNA first formed metastable micelles via an entropy-driven process, which were then enthalpically transformed into am-TDF.


Assuntos
Micelas , Nanoestruturas , DNA/química , Entropia , Nanoestruturas/química
19.
Small ; 18(30): e2201417, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35801427

RESUMO

Plants are anatomically and physiologically different from humans and animals; however, there are several possibilities to utilize the unique structures and physiological systems of plants and adapt them to new emerging technologies through a strategic biomimetic approach. Moreover, plants provide safe and sustainable results that can potentially solve the problem of mass-producing practical materials with hazardous and toxic side effects, particularly in the biomedical field, which requires high biocompatibility. In this review, it is investigated how micro-nanostructures available in plants (e.g., nanoparticles, nanofibers and their composites, nanoporous materials, and natural micromotors) are adapted and utilized in the design of suitable materials for a micro-nanorobot platform. How plants' work on micro- and nanoscale systems (e.g., surface roughness, osmotically induced movements such as nastic and tropic, and energy conversion and harvesting) that are unique to plants, can provide functionality on the platform and become further prospective resources are examined. Furthermore, implementation across organisms and fields, which is promising for future practical applications of the plant-actuated micro-nanorobot platform, especially on biomedical applications, is discussed. Finally, the challenges following its implementation in the micro-nanorobot platform are also presented to provide advanced adaptation in the future.


Assuntos
Nanopartículas , Nanoestruturas , Animais , Biomimética , Humanos , Nanoestruturas/química , Nanotecnologia/métodos
20.
Toxicology ; 476: 153253, 2022 06 30.
Artigo em Inglês | MEDLINE | ID: mdl-35811011

RESUMO

The adsorption of biological molecules to nanomaterials (NMs) will significantly impact NMs' behavior in complex microenvironments. Previously we proposed the need to consider the interactions between food components and NMs for the evaluation of oral toxicity of NMs. This review updated this concept as nutrient molecule corona, that the adsorption of nutrient molecules alters the uptake of nutrient molecules and/or NMs, as well as the signaling pathways to induce a combined toxicity due to the biologically active nature of nutrient molecules. Even with the presence of protein corona, nutrient molecules may still bind to NMs to change the identities of NMs in vivo. Furthermore, this review proposed the binding of excessive nutrient molecules to NMs to induce a combined toxicity under pathological conditions such as metabolic diseases. The structures of nutrient molecules and physicochemical properties of NMs determine nutrient molecule corona formation, and these aspects should be considered to limit the unwanted effects brought by nutrient molecule corona. In conclusion, similar to other biological molecule corona, the formation of nutrient molecule corona due to the presence of food components or excessive nutrient molecules in pathophysiological microenvironments will alter the behaviors of NMs.


Assuntos
Nanoestruturas , Coroa de Proteína , Nanoestruturas/química , Nanoestruturas/toxicidade , Nutrientes
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