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1.
Bull Exp Biol Med ; 176(5): 645-648, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38727954

RESUMO

Using the method of dominant lethal mutations, we assessed the frequency of the death of Drosophila melanogaster embryos under combined exposure to ionizing γ-radiation and non-ionizing pulsed magnetic field at various doses and modes of exposure. Mutagenic effect of combined exposure is antagonistic in nature. The antagonism is more pronounced when the following mode of exposure was used: exposure to non-ionizing pulsed magnetic field for 5 h followed by exposure to γ-radiation at doses of 3, 10, and 60 Gy. In case of reverse sequence of exposures, the antagonistic effect was statistically significant after exposure to γ-radiation at doses of 3 and 10 Gy, whereas at a dose of 20 Gy, a synergistic interaction was noted.


Assuntos
Drosophila melanogaster , Raios gama , Animais , Drosophila melanogaster/efeitos da radiação , Drosophila melanogaster/genética , Raios gama/efeitos adversos , Radiação Eletromagnética , Relação Dose-Resposta à Radiação , Campos Eletromagnéticos/efeitos adversos , Embrião não Mamífero/efeitos da radiação , Radiação Ionizante , Mutação/efeitos da radiação , Mutagênese/efeitos da radiação
2.
PLoS One ; 19(5): e0299017, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38758777

RESUMO

A growing threat to male infertility has become a major concern for the human population due to the advent of modern technologies as a source of radiofrequency radiation (RFR). Since these technologies have become an integral part of our daily lives, thus, it becomes necessary to know the impression of such radiations on human health. In view of this, the current study aims to focus on the biological effects of radiofrequency electromagnetic radiations on mouse Leydig cell line (TM3) in a time-dependent manner. TM3 cells were exposed to RFR emitted from 4G cell phone and also exposed to a particular frequency of 1800 MHz and 2450 MHz from RFR exposure system. The cells were then evaluated for different parameters such as cell viability, cell proliferation, testosterone production, and ROS generation. A considerable reduction in the testosterone levels and proliferation rate of TM3 cells were observed at 120 min of exposure as compared to the control group in all exposure settings. Conversely, the intracellular ROS levels showed a significant rise at 60, 90 and 120 min of exposure in both mobile phone and 2450 MHz exposure groups. However, RFR treatment for different time durations (15, 30, 45, 60, 90, and 120 min) did not have significant effect on cell viability at any of the exposure condition (2450 MHz, 1800 MHz, and mobile phone radiation). Therefore, our findings concluded with the negative impact of radiofrequency electromagnetic radiations on Leydig cell's physiological functions, which could be a serious concern for male infertility. However, additional studies are required to determine the specific mechanism of RFR action as well as its long-term consequences.


Assuntos
Proliferação de Células , Sobrevivência Celular , Células Intersticiais do Testículo , Ondas de Rádio , Espécies Reativas de Oxigênio , Testosterona , Masculino , Células Intersticiais do Testículo/efeitos da radiação , Células Intersticiais do Testículo/metabolismo , Animais , Camundongos , Espécies Reativas de Oxigênio/metabolismo , Ondas de Rádio/efeitos adversos , Proliferação de Células/efeitos da radiação , Testosterona/metabolismo , Sobrevivência Celular/efeitos da radiação , Linhagem Celular , Telefone Celular , Radiação Eletromagnética
3.
Environ Sci Pollut Res Int ; 31(24): 35161-35172, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38724846

RESUMO

Modern life is filled with radiofrequency electromagnetic radiation (RF-EMR) in various frequency bands, while the health risks are not clear. In this study, mice were whole-body exposed to 0.9/1.5/2.65 GHz radiofrequency radiation at 4 W/kg for 2 h per day for 4 weeks to investigate the emotional effects. It was found that the mice showed anxiety but no severe depression. The ELISA results showed a significant decrease in amino acid neurotransmitters (GABA, DA, 5-HT), although acetylcholine (ACH) levels were not significantly altered. Furthermore, Western blot results showed that BDNF, TrkB, and CREB levels were increased in the cerebral cortex, while NF-κB levels were decreased. In addition, pro-inflammatory factors (IL-6, IL-1ß, TNF-α) were significantly elevated, and anti-inflammatory factors (IL-4, IL-10) tended to decrease. In conclusion, multi-frequency electromagnetic radiation induces an inflammatory response through the CREB-BDNF-TrkB and NF-κB pathways in the cerebral cortex and causes a decrease in excitatory neurotransmitters, which ultimately causes anxiety in mice.


Assuntos
Ansiedade , Córtex Cerebral , Radiação Eletromagnética , Inflamação , Animais , Camundongos , Córtex Cerebral/efeitos da radiação , Masculino , Fator Neurotrófico Derivado do Encéfalo/metabolismo , NF-kappa B/metabolismo
4.
Chem Rev ; 124(11): 7165-7213, 2024 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-38758918

RESUMO

Melanin, especially integumentary melanin, interacts in numerous ways with electromagnetic radiation, leading to a set of critical functions, including radiation protection, UV-protection, pigmentary and structural color productions, and thermoregulation. By harnessing these functions, melanin and melanin-like materials can be widely applied to diverse applications with extraordinary performance. Here we provide a unified overview of the melanin family (all melanin and melanin-like materials) and their interactions with the complete electromagnetic radiation spectrum (X-ray, Gamma-ray, UV, visible, near-infrared), which until now has been absent from the literature and is needed to establish a solid fundamental base to facilitate their future investigation and development. We begin by discussing the chemistries and morphologies of both natural and artificial melanin, then the fundamentals of melanin-radiation interactions, and finally the exciting new developments in high-performance melanin-based functional materials that exploit these interactions. This Review provides both a comprehensive overview and a discussion of future perspectives for each subfield of melanin that will help direct the future development of melanin from both fundamental and applied perspectives.


Assuntos
Radiação Eletromagnética , Melaninas , Melaninas/química , Melaninas/metabolismo , Humanos , Animais
5.
Proc Natl Acad Sci U S A ; 121(15): e2313903121, 2024 Apr 09.
Artigo em Inglês | MEDLINE | ID: mdl-38557178

RESUMO

Electromagnetic radiation (EMR) in the environment, particularly in the microwave range, may constitute a public health concern. Exposure to 2.4 GHz EMR modulated by 100 Hz square pulses was recently reported to markedly increase wakefulness in mice. Here, we demonstrate that a similar wakefulness increase can be induced by the modulation frequency of 1,000 Hz, but not 10 Hz. In contrast to the carrier frequency of 2.4 GHz, 935 MHz EMR of the same power density has little impact on wakefulness irrespective of modulation frequency. Notably, the replacement of the 100 Hz square-pulsed modulation by sinusoidal-pulsed modulation of 2.4 GHz EMR still allows a marked increase of wakefulness. In contrast, continuous sinusoidal amplitude modulation of 100 Hz with the same time-averaged power output fails to trigger any detectable change of wakefulness. Therefore, alteration of sleep behavior by EMR depends upon not just carrier frequency but also frequency and mode of the modulation. These results implicate biological sensing mechanisms for specific EMR in animals.


Assuntos
Radiação Eletromagnética , Vigília , Camundongos , Animais , Campos Eletromagnéticos
6.
Environ Sci Pollut Res Int ; 31(21): 31015-31027, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38619766

RESUMO

The 5G sub-6 GHz radio frequency (RF) electromagnetic fields (EMF) are the most widely used in China's communications. The public has expressed concerns about possible brain health effects of the higher frequency bands in 5G compared to 2G, 3G, and 4G bands. It is imperative to empirically investigate the potential health hazards of these novel frequency bands in 5G communication technology. This study evaluates the assessment of brain tissue dose coupling from sub-6 GHz band EMF emitted by base stations in China. Based on the 3D virtual human body model, the simulation environment was established. Dose including specific absorption rate (SAR) and internal electric field (IEF) between 2G, 3G, and 4G bands and 5G sub-6 GHz was investigated using normalized exposure values and exposure limits. The results indicate that the sub-6 GHz high-frequency band of 5G has the lowest dose value. It can be concluded that high-frequency electromagnetic radiation in 5G sub-6 GHz reduces the dose and health threats to the brain. This provides strong support for the promotion of 5G commutation in China and other regions.


Assuntos
Encéfalo , Campos Eletromagnéticos , Ondas de Rádio , China , Humanos , Encéfalo/efeitos da radiação , Radiação Eletromagnética
7.
Electromagn Biol Med ; 43(1-2): 117-124, 2024 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-38521997

RESUMO

This paper presents data on pain perception in rats exposed to 6 GHz radiofrequency electromagnetic radiation (RF-EMR). Rats were divided into two groups: control (n = 10, 4 replicates per test) and RF-EMR exposed group (n = 10, 4 replicates per test). Nociceptive responses of the groups were measured using rodent analgesiometry. Rats were divided into control and RF-EMR exposed groups. Nociceptive responses were measured using rodent analgesiometry. RF-EMR exposed rats had a 15% delay in responding to hot plate thermal stimulation compared to unexposed rats. The delay in responding to radiant heat thermal stimulation was 21%. We determined that RF-EMR promoted the occurrence of pressure pain as statistical significance by + 42% (p < 0.001). We observed that RF-EMR exposure increased nociceptive pain by + 35% by promoting cold plate stimulation (p < 0.05). RF-EMR exposure did not affect thermal preference as statistical significance but did support the formation of pressure pain perception.


In this study, we present data on pain perception in rats exposed to 6GHz RF-EMR. RF-EMR exposed rats showed delayed responses to hot plate and radiant heat thermal stimulation. RF-EMR increased pressure and nociceptive pain as statistically significance. In particular, the effects of RF-EMR should be considered when assessing hyperalgesic and hypoalgesic symptoms in the clinic. The results of this study indicate the need to take precautions against the possible negative effects of RF-EMR on human health with the rise of 5G technology.


Assuntos
Percepção da Dor , Ondas de Rádio , Animais , Ratos , Percepção da Dor/efeitos da radiação , Ondas de Rádio/efeitos adversos , Masculino , Radiação Eletromagnética , Ratos Sprague-Dawley , Temperatura Alta
8.
Zygote ; 32(2): 149-153, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38384250

RESUMO

Electromagnetic radiation (EMR) has deleterious effects on sperm motility and viability, as well as oocyte membrane and organelle structure. The aim was to assess the effects of cell phone radiation on preimplantation embryo morphokinetics and blastocyst viability in mice. For superovulation, 20 female mice were treated with intraperitoneal (IP) injections of 10 IU pregnant mare's serum gonadotropin (Folligon® PMSG), followed by 10 IU of human chorionic gonadotropin (hCG) after 48 h. The zygotes (n = 150) from the control group were incubated for 4 days. The experimental zygotes (n = 150) were exposed to a cell phone emitting EMR with a frequency range 900-1800 MHz for 30 min on day 1. Then, all embryos were cultured in the time-lapse system and annotated based on time points from the 2-cell stage (t2) to hatched blastocyst (tHDyz), as well as abnormal cleavage patterns. Blastocyst viability was assessed using Hoechst and propidium iodide staining. Significant increases (P < 0.05) were observed in the cleavage division time points of t2, t8, t10, and t12 of the experimental group compared with the controls. In terms of blastocyst formation parameters, a delay in embryo development was observed in the experimental group compared with the controls. Data analysis of the time intervals between the two groups showed a significant difference in the s3 time interval (P < 0.05). Also, the rates of fragmentation, reverse cleavage, vacuole formation, and embryo arrest were significantly higher in the experimental group (P < 0.05). Furthermore, the cell survival rate in the experimental group was lower than the control group (P < 0.05). Exposure to EMR has detrimental consequences for preimplantation embryo development in mice. These effects can manifest as defects in the cleavage stage and impaired blastocyst formation, leading to lower cell viability.


Assuntos
Blastocisto , Telefone Celular , Radiação Eletromagnética , Desenvolvimento Embrionário , Animais , Feminino , Blastocisto/efeitos da radiação , Blastocisto/fisiologia , Blastocisto/citologia , Camundongos , Desenvolvimento Embrionário/efeitos da radiação , Masculino , Gravidez , Técnicas de Cultura Embrionária/métodos , Sobrevivência Celular/efeitos da radiação , Superovulação/efeitos da radiação
9.
Artigo em Russo | MEDLINE | ID: mdl-38372736

RESUMO

OBJECTIVE: To identify features of development of adaptive protective reactions when applying drinking sulfate mineral water (MW) and low-intensity electromagnetic radiation of extremely high frequency (EMR EHF) against the background of a high-calorie diet and after its elimination at an early stage of development of experimental metabolic syndrome. MATERIAL AND METHODS: Experiments were conducted on 40 non-linear male rats with 200-220 g. weight. The model of metabolic syndrome was reproduced for 60 days. All animals were divided into 5 groups: 2 study groups, 2 control groups and 1 intact one. Rats of the 1st study group were given sulfate MW in combination with EMR EHF against the background of a high-calorie diet, controlled by rats receiving only a high-energy diet. Rats of the 2nd study group also received sulfate MW in combination with EMR EHF but when the metabolic syndrome simulation was finished and the high-calorie diet was eliminated, control was done by rats that were given standard food after eliminating the high-energy diet. Liver, testes and blood were objects of the study. Light-optical, morphometric methods of examination and electron microscopy were used. RESULTS AND DISCUSSION: The use of sulfate MW in combination with EMR EHF against the background of the high-calorie diet was the most cause of increased activity of the antioxidant system and the plastic processes were weaker; the activation of natural adaptive reactions was noted after the elimination of the diet that in combination with actions of MW and EMR EHF led to the further intensification of protein synthesis (RNA, DNA, total protein), intensification of cellular and intracellular regeneration processes. The identified adaptive shifts during the action of the studied factors were caused by their antioxidant, membrane stabilizing and detoxifying actions. CONCLUSION: The results of the study can be used to develop the problem of regulating adaptive reactions with the application of therapeutic physical factors and to create new highly effective methods of preventing and treating metabolic syndrome.


Assuntos
Água Potável , Síndrome Metabólica , Masculino , Animais , Ratos , Antioxidantes , Minerais , Radiação Eletromagnética , Sulfatos
11.
Nano Lett ; 24(4): 1145-1152, 2024 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-38194429

RESUMO

We present a novel technique of genetic transformation of bacterial cells mediated by high frequency electromagnetic energy (HF EME). Plasmid DNA, pGLO (5.4 kb), was successfully transformed into Escherichia coli JM109 cells after exposure to 18 GHz irradiation at a power density between 5.6 and 30 kW m-2 for 180 s at temperatures ranging from 30 to 40 °C. Transformed bacteria were identified by the expression of green fluorescent protein (GFP) using confocal scanning microscopy (CLSM) and flow cytometry (FC). Approximately 90.7% of HF EME treated viable E. coli cells exhibited uptake of the pGLO plasmid. The interaction of plasmid DNA with bacteria leading to transformation was confirmed by using cryogenic transmission electron microscopy (cryo-TEM). HF EME-induced plasmid DNA transformation was shown to be unique, highly efficient, and cost-effective. HF EME-induced genetic transformation is performed under physiologically friendly conditions in contrast to existing techniques that generate higher temperatures, leading to altered cellular integrity. This technique allows safe delivery of genetic material into bacterial cells, thus providing excellent prospects for applications in microbiome therapeutics and synthetic biology.


Assuntos
Escherichia coli , Transformação Bacteriana , Plasmídeos/genética , DNA/metabolismo , Bactérias/genética , Radiação Eletromagnética
12.
Electromagn Biol Med ; 43(1-2): 19-30, 2024 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-38278143

RESUMO

Electromagnetic radiation (EM) pollution has a certain impact on human life and health, and the reconstruction of the EM space field in this paper is of great practical significance for EM analysis and research. The radial basis function (RBF) sufficiently considers the influence of each sampling point and is more suitable for reconstructing the EM space field than other spatial interpolation methods. Currently, when RBF is used to reconstruct the EM space field, the optimal determination of the basis function and shape parameter (SP) is rarely considered. This ultimately leads to low reconstruction accuracy of the EM space field. Therefore, in this paper, the particle swarm optimization (PSO) is used to calculate the optimal SP of the RBF. On this basis, reliable EM space field reconstruction is performed, which helps people understand the EM distribution characteristics in actual situations from a visual perspective. The EM sampling data of a region on the Yunnan Normal University campus are used as the data source, and the RBF under the optimal parameters is used for EM reconstruction. The accuracy of its interpolation results is evaluated and compared and analyzed with inverse distance weighting (IDW) after distance index optimization. The results show that the RBF under optimal parameters reconstructs the EM space field with high accuracy and good effect, which can truly reflect the actual distribution of EM.


Electromagnetic radiation (EM) pollution has a great impact on the surrounding environment. Therefore, EM space field reconstruction can help us analyze the characteristics of the electromagnetic environment in a visual way. Radial Basis Function (RBF) is a method more suitable for EM space field reconstruction than other methods because it fully considers the influence of each sampling point. However, when currently using RBF to reconstruct the EM space field, few researchers consider how to choose the most appropriate basis function and shape parameter (SP). This results in low reconstruction accuracy. Therefore, this study uses particle swarm optimization (PSO) to find the optimal SP parameters for reliable EM space field reconstruction. The study used the EM sampling data of an area within the campus of Yunnan Normal University as the study material, and a parameter-optimized RBF method was adopted for the reconstruction of the EM space field. The reconstruction results were then evaluated for accuracy and compared and analyzed with the IDW method optimized with a distance index. Research results show that using RBF with optimal parameters to reconstruct the EM space field has high accuracy and can effectively reflect the actual EM distribution, thereby helping people better understand the characteristics of the electromagnetic environment.


Assuntos
Radiação Eletromagnética
13.
Aesthetic Plast Surg ; 48(6): 1156-1165, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37957393

RESUMO

BACKGROUND: Emsculpt Neo (EmSculpt NEO Device, BTL Industries, Inc.) is a FDA-cleared noninvasive body contouring treatment for increasing muscle tone and/or reducing fat. The device uses high-intensity electromagnetic energy to stimulate muscle contractions and to build muscle mass (Emsculpt) or a combination of electromagnetic energy with radiofrequency (Emsculpt NEO) to produce a synergistic effect of building muscle mass and reducing fat. In this study, we conduct a high-quality systematic review to evaluate outcomes for Emsculpt and Emsculpt NEO treatments for noninvasive body contouring. METHODS: An electronic search was performed of the PubMed, MEDLINE, Embase, and Web of Science databases using the key terms "High intensity focused electromagnetic therapy; HIFEM; Emsculpt; Emsculpt NEO; BTL Industries." The search included all articles published in English through January 2023. Inclusion criteria included articles noninvasive body contouring and reporting at least one outcome of interest (clinical or patient-reported outcomes). Methodological quality and risk of bias were assessed using the GRADE criteria. Articles involving applications other than for body contouring, animal studies, and review articles were excluded. RESULTS: Of the 159 articles identified in the initial search strategy, 51 met relevance based on abstract screening. Fifteen clinical studies were identified, including Emsculpt (n=11) and Emsculpt NEO (n=2). The typical protocol involved four treatments given over a 2-4-week period (range 3-8 treatments) with increase to 100% intensity setting and 1-6-month follow-ups. No complications were reported. Abdominal measurements were obtained using imaging were reported in eight studies. Treated areas included the buttocks (n=4), thighs (n=3), arms or calves (n=1), and abdomen (n=11). For abdominal contouring, mean reductions of fat thickness were 5.5 mm, muscle thickness of 2 mm, and rectus diastasis improvement of 3.0 mm. No studies reported weight change before and after treatment. All studies with patient-reported outcomes report high patient satisfaction. Two studies report marginal or no benefit of treatment. Certain studies failed to report comorbidities or demographic characteristics other than age and sex, which precludes analysis of specific subgroups that may benefit from treatment. Furthermore, certain studies failed to address how missing data or the final study population was analyzed. CONCLUSION: This systematic review reports on currently published evidence regarding the efficacy and safety of Emsculpt and Emsculpt NEO for body contouring. High-quality level data reporting with patient-reported outcomes will optimize shared decision-making and informed consent. LEVEL OF EVIDENCE II: Therapeutic study. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .


Assuntos
Contorno Corporal , Humanos , Contorno Corporal/métodos , Resultado do Tratamento , Satisfação do Paciente , Radiação Eletromagnética , Perna (Membro)
14.
Radiat Prot Dosimetry ; 199(20): 2455-2463, 2023 Dec 21.
Artigo em Inglês | MEDLINE | ID: mdl-38126857

RESUMO

CeO2-NPs (nanoparticles) exhibit a variety of properties, which have prompted researchers to explore various applications, such as gas sensing, biomedical, Electromagnetic Interference (EMI) shielding, etc. Zn-doped CeO2-NPs with concentrations ranging from 7 to 11 mol were synthesised using Aloe vera extract as a reducing agent by the solution combustion method. As obtained, NPs were characterised by standard techniques. Braggs reflections confirm the formation of a single-phase cubic structure of CeO2Zn NPs. Crystalline size is calculated using both the W-H plot and the Scherrer equation, which were found to be 12 and 9 nm, respectively. The Energy-dispersive X-ray analysis (EDAX) pattern confirmed the presence of Ce, O and Zn. The direct energy band values are found to be decreasing from 3 to 2.87 eV with an increase in the doping concentration of Zn from 7 to 11 mol. Total shielding efficiency (SET) will give the best representation of shielding properties. The SEt values of CeO2Zn NPs are compared to those of other conventional materials and NP materials, finding significant applications in EMI shielding.


Assuntos
Fenômenos Eletromagnéticos , Nanopartículas , Radiação Eletromagnética , Zinco
15.
Radiat Prot Dosimetry ; 199(20): 2428-2437, 2023 Dec 21.
Artigo em Inglês | MEDLINE | ID: mdl-38126861

RESUMO

Over a century, shielding harmful electromagnetic radiations (EMR) and finding a suitable material, which can replace lead has become the major interest of researchers in this field. Herein, calcium-iron-chromium oxide nanocomposites with the different atomic ratios are synthesized using the solution combustion method. The as-obtained nanoparticles (NPs) are subjected to several structural and surface characteristics such as powder X-ray diffraction, scanning electron microscopy, elemental diffraction X-ray analysis, Fourier Transform Infrared Spectroscopy and UV-visible spectroscopy analysis were performed to confirm the successful synthesis. Furthermore, the EMR shielding of as-procured NPs is investigated and observed that the obtained NPs show good shielding properties.


Assuntos
Cálcio , Nanocompostos , Ferro , Fenômenos Eletromagnéticos , Cromo , Radiação Eletromagnética
16.
PLoS One ; 18(12): e0291354, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38127949

RESUMO

This study introduces a metasurface (MS) based electrically small resonator for ambient electromagnetic (EM) energy harvesting. It is an array of novel resonators comprising double-elliptical cylinders. The harvester's input impedance is designed to match free space, allowing incident EM power to be efficiently absorbed and then maximally channelled to a single load through optimally positioned vias. Unlike the previous research works where each array resonator was connected to a single load, in this work, the received power by all array resonators is channelled to a single load maximizing the power efficiency. The performance of the MS unit cell, when treated as an infinite structure, is examined concerning its absorption and harvesting efficiency. The numerical results demonstrate that the MS unit cell can absorb EM power, with near-perfect absorption of 90% in the frequency range of 5.14 GHz to 5.5 GHz under normal incidence and with a fractional bandwidth of 21%. The MS unit cell also achieves higher harvesting efficiency at various incident angles up to 60o. The design and analysis of an array of 4x4 double elliptical cylinder MS resonators integrated with a corporate feed network are also presented. The corporate feed network connects all the array elements to a single load, maximizing harvesting efficiency. The simulation and measurement results reveal an overall radiation to AC efficiency of about 90%, making it a prime candidate for energy harvesting applications.


Assuntos
Eletricidade , Radiação Eletromagnética , Simulação por Computador , Impedância Elétrica
17.
Altern Ther Health Med ; 29(8): 75-81, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37678874

RESUMO

Objective: Leukemia is the most prevalent cancer among children and adolescents. This study investigated the potential association between exposure to magnetic fields and the risk of pediatric leukemia. Methods: We conducted a comprehensive search of electronic databases, including Scopus, EMBASE, Cochrane, Web of Science, and Medline, up to December 15, 2022, to identify relevant studies examining the link between childhood leukemia and magnetic field exposure. Results: The first meta-analysis revealed a statistically significant inverse association between pediatric leukemia and magnetic field strengths ranging from 0.4 µT to 0.2 µT, suggesting a reduced risk associated with this range. The second meta-analysis focused on wiring configuration codes and observed a potential link between residential magnetic field exposure and childhood leukemia. Pooled relative risk estimates were 1.52 (95% CI = 1.05-2.04, P = .021) and 1.58 (95% CI = 1.15-2.23, P = .006) for exposure to 24-hour magnetic field measurements, suggesting a possible causal relationship. In the third meta-analysis, the odds ratios for the exposure groups of 0.1 to 0.2 µT, 0.2 to 0.3 µT, 0.3 to 0.4 µT, and 0.4 µT above 0.2 µT were 1.09 (95% confidence interval = 0.82 to 1.43 µT), 1.14 (95% confidence interval = 0.68 to 1.92 µT), and 1.45 (95% confidence interval = 0.87 to 2.37 µT), respectively. In contrast to the findings of the three meta-analyses, there was no evidence of a statistically significant connection between exposure to 0.2 µT and the risk of juvenile leukemia. A further result showed no discernible difference between the two groups of children who lived less than 100 meters from the source of magnetic fields and those who lived closer (OR = 1.33; 95% CI = 0.98-1.73 µT). Conclusions: The collective results of three meta-analyses, encompassing magnetic field strengths ranging from 0.1 µT to 2.38 µT, underscore a statistically significant association between the intensity of magnetic fields and the occurrence of childhood leukemia. However, one specific analysis concluded that no apparent relationship exists between exposure to 0.1 µT and an elevated risk of leukemia development in children.


Assuntos
Leucemia , Neoplasias , Adolescente , Criança , Humanos , Campos Eletromagnéticos/efeitos adversos , Leucemia/epidemiologia , Leucemia/etiologia , Campos Magnéticos , Radiação Eletromagnética , Exposição Ambiental/efeitos adversos , Estudos de Casos e Controles
18.
Int J Neurosci ; 133(12): 1424-1436, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37712630

RESUMO

BACKGROUND: Due to children and adolescents' widespread use of electronic devices, researchers have focused on pre-and early postnatal electromagnetic field (EMF) exposure. However, little is known about the effects of EMF exposure on the optic nerve. The aim of study was to investigate the changes occurring in the optic nerve and the protective effects of melatonin (mel) and omega 3 (ω-3) in rats. METHODS: Thirty-five pregnant rats were divided into seven groups, Cont, Sham, EMF, EMF + melatonin (EMF + Mel), EMF + ω3, Mel, and ω3. The EMF groups were exposed to 900 megahertz (MHz) EMF daily for two hours during pregnancy. After the experiment, the right optic nerve of each offspring rat was removed and fixed in glutaraldehyde. Thin and semi-thin sections were taken for electron microscopic and stereological analyses. Myelinated axon numbers, myelin sheath thicknesses, and axonal areas were estimated using stereological methods. RESULTS: The groups had no significant differences regarding mean numbers of axons, mean axonal areas, or mean myelin sheath thicknesses (p > 0.05). Histological observations revealed impaired lamellae in the myelin sheath of most axons, and vacuolization was frequently observed between the myelin sheath and axon in the EMF-exposed group. The Mel and ω-3-treated EMF groups exhibited well-preserved myelinated nerve fibers and intact astrocytes and oligodendrocytes. CONCLUSIONS: At the ultrastructural level, Mel and ω3 exhibits a neuroprotective effect on the optic nerve exposed to prenatal EMF. The protective effects of these antioxidants on oligodendrocytes, which play an essential role in myelin formation in the central nervous system, now require detailed investigation.


Assuntos
Melatonina , Humanos , Feminino , Gravidez , Criança , Ratos , Masculino , Animais , Adolescente , Melatonina/farmacologia , Campos Eletromagnéticos , Antioxidantes/farmacologia , Radiação Eletromagnética
19.
Vet Med Sci ; 9(6): 2648-2659, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-37725264

RESUMO

BACKGROUND: The risks to human health have grown over the past 10 years due to the excessive use of mobile phones. OBJECTIVES: The study was designed to determine the harmful effects of 4G mobile phone radiation on the expression of immunogenic and vascular genes and gross, microscopic and biochemical alterations in the development of chicken embryos. METHODS: Sixty individuals in the exposure group were subjected to mobile phones with a specific absorption rate of 1.4 W/kg and a frequency of 2100 MHz positioned at a distance of 12 cm in the incubator for 60 min/night for 14 days. The histopathological examination involved hematoxylin and eosin staining, whereas cresyl violet staining was used to evaluate the condition and number of neurons in the brain. The biochemical parameters of amniotic fluid were analysed using the photometry method, and the expression of VEGF-A and immunity genes (AvBD9, IL6) was measured using the real-time PCR (qPCR) technique. RESULTS: Compared to the control, the exposure group's body weight and length significantly decreased (p < 0.05). Subcutaneous bleeding was seen in the exposure group. Urea, creatinine, alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase levels were all significantly higher than in the control group (p < 0.05). The exposed group showed pathological lesions in the liver and degenerated neurons with lightly stained nuclei in the cerebral cortex. Hyperchromatic neurons were significantly higher in the exposure group (58.8 ± 2.28) compared to the control (6.6 ± 0.44) (p < 0.05). 4G exposure reduced lymphocyte count in the caecal tonsil (86.8 ± 5.38) compared to the control (147.2 ± 9.06) (p < 0.05). Vascular gene mRNA expression was higher, but immune gene expression was lower in the exposed group. CONCLUSION: Exposure to mobile phone radiation may result in gross, microscopic and biochemical changes, as well as alterations in gene expression that could hinder embryonic development.


Assuntos
Telefone Celular , Radiação Eletromagnética , Feminino , Gravidez , Embrião de Galinha , Humanos , Animais , Galinhas , Encéfalo , Expressão Gênica
20.
J Neuroeng Rehabil ; 20(1): 129, 2023 09 26.
Artigo em Inglês | MEDLINE | ID: mdl-37752553

RESUMO

PURPOSE: Tremor is one of the key characteristics of Parkinson's disease (PD), leading to physical disabilities and often showing limited responses to pharmacological treatments. To suppress tremors in PD patients, several types of non-invasive and non-pharmacological methods have been proposed so far. In the current systematic review, three electromagnetic-based radiation strategies including electrical stimulation, magnetic stimulation, and light stimulation methods were reviewed and compared. METHODS: Major databases were searched to retrieve eligible studies. For the meta-analysis, a random-effect Bayesian framework was used. Also, heterogeneity between studies was assessed using I2 statistic, prediction interval, and tau2. Publication bias was assessed using funnel plot, and the effectiveness of methods for reducing tremor was compared using network Bayesian meta-analysis. RESULTS AND CONCLUSION: Thirty-one studies were found for qualitative analysis, and 16 studies were found for quantitative synthesis. Based on the suppression ratio, methods can be ordered as electrical stimulation, light therapy, and magnetic stimulation. Furthermore, the results showed that electrical and magnetic stimulation were more effective for tremor suppression at early stages of PD, while light therapy was found to be more effective during the later stages of PD.


Assuntos
Terapia por Estimulação Elétrica , Doença de Parkinson , Humanos , Teorema de Bayes , Terapia por Estimulação Elétrica/efeitos adversos , Fenômenos Eletromagnéticos , Radiação Eletromagnética , Fenômenos Magnéticos , Doença de Parkinson/radioterapia , Tremor/etiologia , Tremor/terapia , Revisões Sistemáticas como Assunto , Metanálise como Assunto
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