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1.
Int J Infect Dis ; 115: 48-61, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34838720

RESUMO

OBJECTIVES: This study is aimed to report a case of SV-related gastritis and the results of a systematic literature review of SV infections. METHODS: Following a case presentation, we systematically searched different databases (MEDLINE, PubMed, Scopus, Web of Science, EMBASE, google scholar) for the items "sarcina," "ventriculi," "clostridium" with AND/OR. RESULTS: A total of 55 articles reporting 65 cases of Sarcina Ventriculi were found. Thus, 66 patients, including our case, were reviewed. The median age was 51 years (IQR: 0-87 years). Females accounted for 51% of cases. 68% of patients had one or more comorbidities. SV was isolated in the gastrointestinal tract (88%), respiratory (5%), urine (4%), and bloodstream (3%) systems. Upper endoscopy was performed in 52 patients (79%). Biopsies were obtained in all 52 cases and were normal in 23%. Surgery was warranted in 15 patients (23%), and specific antimicrobial therapy was delivered in 34 (52%) patients. Mortality was 14%. At follow-up, 88% of patients showed complete eradication of the SV infection. CONCLUSIONS: Upper gastrointestinal biopsy positive for SV should prompt an evaluation of the clinical conditions, considering the risk of gastric perforation is not negligible. Antibiotic therapy may eradicate the infection and prevent complications. Emergency surgery is required in case of source control.


Assuntos
Sarcina , Gastropatias , Antibacterianos/uso terapêutico , Clostridium , Feminino , Humanos , Pessoa de Meia-Idade
2.
Nat Commun ; 12(1): 763, 2021 02 03.
Artigo em Inglês | MEDLINE | ID: mdl-33536429

RESUMO

Human and animal infections with bacteria of the genus Sarcina (family Clostridiaceae) are associated with gastric dilation and emphysematous gastritis. However, the potential roles of sarcinae as commensals or pathogens remain unclear. Here, we investigate a lethal disease of unknown etiology that affects sanctuary chimpanzees (Pan troglodytes verus) in Sierra Leone. The disease, which we have named "epizootic neurologic and gastroenteric syndrome" (ENGS), is characterized by neurologic and gastrointestinal signs and results in death of the animals, even after medical treatment. Using a case-control study design, we show that ENGS is strongly associated with Sarcina infection. The microorganism is distinct from Sarcina ventriculi and other known members of its genus, based on bacterial morphology and growth characteristics. Whole-genome sequencing confirms this distinction and reveals the presence of genetic features that may account for the unusual virulence of the bacterium. Therefore, we propose that this organism be considered the representative of a new species, named "Candidatus Sarcina troglodytae". Our results suggest that a heretofore unrecognized complex of related sarcinae likely exists, some of which may be highly virulent. However, the potential role of "Ca. S. troglodytae" in the etiology of ENGS, alone or in combination with other factors, remains a topic for future research.


Assuntos
Doenças dos Símios Antropoides/diagnóstico , Enfisema/diagnóstico , Gastrite/diagnóstico , Infecções por Bactérias Gram-Positivas/diagnóstico , Sarcina/genética , Animais , Doenças dos Símios Antropoides/microbiologia , DNA Bacteriano/análise , DNA Bacteriano/genética , Enfisema/microbiologia , Gastrite/microbiologia , Infecções por Bactérias Gram-Positivas/microbiologia , Infecções por Bactérias Gram-Positivas/veterinária , Humanos , Pan troglodytes , Sarcina/classificação , Sarcina/patogenicidade , Serra Leoa , Virulência/genética , Sequenciamento Completo do Genoma/métodos
3.
Autops. Case Rep ; 11: e2021337, 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1345356

RESUMO

Sarcina ventriculi is a gram-positive bacterium, able to survive in extreme low pH environment. It's first description dates from 1842, by John Goodsir. Since then, just a few cases have been reported. In veterinary medicine, especially in ruminants, it causes bloating, vomiting, gastric perforation and death of the animal. It is commonly associated with delayed gastric emptying or obstruction to gastric outlet, although it's pathogenicity in humans is not fully understood. We report two cases with identification of the bacteria in gastric specimens stained with hematoxylin-eosin staining, in different clinical settings. The first patient is a young female patient, presenting cardiac arrest and death after gastric perforation and the second patient an adult male presenting with gastric adenocarcinoma, treated with partial gastrectomy followed by adjuvant chemoradiation. In our literature review, we identified forty-five cases reporting Sarcina ventriculi appearance, with a sudden increase since 2010.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Pessoa de Meia-Idade , Sarcina/patogenicidade , Infecções por Clostridium/patologia , Gastroparesia/complicações
5.
Scott Med J ; 65(2): 40-45, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32208839

RESUMO

In 1842, when John Goodsir was Conservator to the Museum of the RCSEd, he saw a 19-year-old male patient who vomited a large volume of acidic, fermented-smelling, watery fluid every morning. Under his microscope, Goodsir found the vomitus to be populated with a micro-organism he named Sarcina ventriculi, which he considered to be causative. In so-doing, Goodsir became one of the first people to link a specific micro-organism with a disease. Goodsir recommended small doses of creosote as an antiseptic and claimed that the boy was eventually cured of the vomiting condition. In August of 1863 Charles Darwin was hugely celebrated by the scientific community and the public, but he had suffered from severe stomach problems all his adult life and at this point, he was vomiting daily. He read Goodsir's paper and contacted him and asked if he could send some vomitus samples to Edinburgh in the hope that Goodsir might find Sarcina in it and solve the mystery of his debilitating stomach symptoms and perhaps cure them with creosote. Goodsir examined samples in his microscope, but failed to find Sarcina. Sadly, Darwin went on to suffer constantly from severe stomach problems, recently attributed to lactose intolerance, until he died in 1882, some 20 years later.


Assuntos
Dispepsia/microbiologia , Infecções por Bactérias Gram-Positivas/diagnóstico , Sarcina/isolamento & purificação , Gastropatias/microbiologia , Vômito/microbiologia , Causalidade , Infecções por Bactérias Gram-Positivas/história , História do Século XIX , Humanos , Masculino , Gastropatias/metabolismo , Adulto Jovem
7.
Int J Surg Pathol ; 28(2): 206-209, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31496372

RESUMO

Sarcina species are anaerobic gram-positive cocci rarely seen in the upper gastrointestinal tract and associated with delayed gastric emptying. We present 3 cases of Sarcina infection with varying clinical presentations including the first reported case of Sarcina in a patient with eosinophilic esophagitis. Although the pathogenesis of Sarcina is unclear, awareness of the bacteria is important as they can usually only be detected on histopathologic examination of upper gastrointestinal biopsies. Treatment in symptomatic patients may prevent severe complications such as emphysematous gastritis and gastric perforation.


Assuntos
Esôfago/microbiologia , Infecções por Bactérias Gram-Positivas/microbiologia , Sarcina/isolamento & purificação , Estômago/microbiologia , Idoso , Antibacterianos/uso terapêutico , Criança , Ciprofloxacina/uso terapêutico , Feminino , Infecções por Bactérias Gram-Positivas/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade
14.
Int J Pharm ; 549(1-2): 436-445, 2018 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-30118833

RESUMO

A promising strategy to design safer and more effective cationic lipids for gene delivery with inherent antibacterial properties is to covalently tether a lipophilic moiety with oligomeric aminoglycosides (AGs), a large family of Gram-negative-active antibiotics. Herein, we reported the development of a new class of multicationic-head AG-based amphiphiles built on the tetramino-tetrahexyloxycalix[4]arene (4A4Hex-calix-calix[4]) scaffold. Three different conjugates, namely 4A4Hex-calix-calix[4]-neomycin, -neamine, and -paromomycin, were synthesized and characterized. Due to the inherent multivalency of AGs and the amphiphilic behaviour, every 4A4Hex-calix-calix[4]-AG exhibited greater DNA binding ability than the gold standard transfectant 25 kDa bPEI and striking DNA packing ability. DNA/4A4Hex-calix-calix[4]-AG complexes at charge ratios (CRs, +/-) used for transfections displayed good colloidal stability, with a hydrodynamic diameters of ≈150 nm and an overall surface charges of ≈+30 mV. DNA/4A4Hex-calix[4]-AGs nanoassemblies, everyone tested at the optimal CR, invariably showed good transfection efficiency in two cell lines, along with low-to-negligible cytotoxicity. Besides, DNA/4A4Hex-calix-calix[4]-AG complexes exhibited appreciable antimicrobial activity against Gram-negative bacteria, even greater than uncomplexed 4A4Hex-calix-calix[4]-AGs. Altogether, these results disclose 4A4Hex-calix[4]-AGs as promising gene delivery tools with unique antibacterial properties.


Assuntos
Antibacterianos/síntese química , Antibacterianos/farmacologia , Calixarenos/síntese química , Calixarenos/farmacologia , Desenho de Fármacos , Escherichia coli/efeitos dos fármacos , Fenóis/síntese química , Fenóis/farmacologia , Tensoativos/síntese química , Tensoativos/farmacologia , Transfecção/métodos , Transporte Ativo do Núcleo Celular , Antibacterianos/metabolismo , Sítios de Ligação , Calixarenos/metabolismo , DNA/química , DNA/metabolismo , Escherichia coli/crescimento & desenvolvimento , Regulação da Expressão Gênica , Células HeLa , Humanos , Estrutura Molecular , Conformação de Ácido Nucleico , Fenóis/metabolismo , Sarcina/efeitos dos fármacos , Sarcina/crescimento & desenvolvimento , Relação Estrutura-Atividade , Propriedades de Superfície , Tensoativos/metabolismo
15.
Diagn Cytopathol ; 46(10): 876-878, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30051973

RESUMO

Sarcina ventriculi is a rare gram-positive, anaerobic bacteria, associated with delayed gastric emptying. We report a case of a 45-year-old lady, who presented with features of gastric outlet obstruction, and coinfection of S. ventriculi and Candida was detected on examining gastric brushings and biopsy. S. ventriculi is identified by its peculiar configuration in the form of tetrads and octets. Coexistence of S. ventriculi with other organisms is highly unusual.


Assuntos
Candida/fisiologia , Coinfecção/microbiologia , Obstrução da Saída Gástrica/microbiologia , Antro Pilórico/microbiologia , Antro Pilórico/patologia , Sarcina/fisiologia , Coinfecção/diagnóstico por imagem , Coinfecção/patologia , Feminino , Obstrução da Saída Gástrica/diagnóstico por imagem , Obstrução da Saída Gástrica/patologia , Humanos , Pessoa de Meia-Idade , Antro Pilórico/diagnóstico por imagem , Tomografia Computadorizada por Raios X
19.
J Am Anim Hosp Assoc ; 53(6): 321-325, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28892423

RESUMO

An 11 yr old spayed female domestic longhair cat was presented for an acute onset of vomiting. Abdominal radiographs and ultrasound revealed severe gastric dilatation (GD) without evidence of gastric outflow obstruction. On esophagogastroduodenoscopy, the duodenal mucosa was mildly erythematous, and a moderate, diffuse, chronic enteritis was found by histological examination of duodenal biopsies. Large numbers of Sarcina-like bacteria without associated inflammation were present in gastric mucosal biopsies. To the authors' knowledge, this is the first report of GD associated with colonization by Sarcina-like bacteria in a cat. Gastric colonization by Sarcina-like bacteria should be suspected when cats are presented with acute onset of GD and vomiting.


Assuntos
Doenças do Gato/diagnóstico , Enterite/veterinária , Dilatação Gástrica/veterinária , Sarcina/isolamento & purificação , Animais , Doenças do Gato/microbiologia , Gatos , Enterite/diagnóstico , Enterite/microbiologia , Feminino , Dilatação Gástrica/diagnóstico , Dilatação Gástrica/microbiologia
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