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1.
Environ Sci Pollut Res Int ; 31(6): 8812-8827, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38180671

RESUMO

Estimating the asymmetrical influence of foreign direct investment is the primary goal of the current study. In addition, further controlled variables affect environmental degradation in OIC nations. Due to this, current research employs the asymmetric (NPARDL) approach and the data period from 1980 to 2021 to estimate about viability of the EKC (environmental Kuznets curve) theory. The study utilized greenhouse gas (GHG) including emissions of carbon dioxide (CO2), nitrous oxide (N2O), methane (CH4), and ecological footprint as substantial parameters of environmental quality. A nonlinear link between foreign direct investments, trade openness, economic growth, urbanization, energy consumption, and environmental pollution with CO2, N2O, CH4, and ecological footprint in the OIC nations is confirmed by the study's outcomes, which however reveals inconsistent results. Furthermore, the results also show that wrong conclusions might result from disregarding intrinsic nonlinearities. The study's conclusions provide the most important recommendations for decision-makers.


Assuntos
Dióxido de Carbono , Transferência de Tecnologia , Dióxido de Carbono/análise , Poluição Ambiental , Internacionalidade , Investimentos em Saúde , Desenvolvimento Econômico , Meio Ambiente
2.
J Behav Health Serv Res ; 51(1): 123-131, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37872261

RESUMO

Technology transfer centers (TTCs) facilitate the movement of evidence-based practices in behavioral healthcare from theory to practice. One of the largest such networks is the Substance Abuse and Mental Health Services Administration's (SAMHSA) TTC Network. This brief report shares findings from an organizational network analysis (ONA) of the network conducted as part of an external evaluation. For non-supervisory TTCs (n = 36) across three focus areas (addiction, prevention, and mental health), the authors computed network density, harmonic closeness, and non-null dyadic reciprocity for five types of interactions (e.g., "collaborated in workgroups"), then, for each interaction type, used Welch's T-test to compare mean harmonic closeness of standalone TTC grantees versus multiple-TTC grantees. ONA identified potentially isolated regional TTCs as well as mismatches between some centers' desired scope and their network centrality and enabled investigation of broader questions around behavioral health support systems. The approach appears useful for evaluating TTCs and similar support networks.


Assuntos
Comportamento Aditivo , Serviços de Saúde Mental , Transtornos Relacionados ao Uso de Substâncias , Estados Unidos , Humanos , United States Substance Abuse and Mental Health Services Administration , Transferência de Tecnologia , Transtornos Relacionados ao Uso de Substâncias/prevenção & controle
3.
Artigo em Inglês | MEDLINE | ID: mdl-38082995

RESUMO

Quantitatively assessing the level of readiness of medical technology improves its chance of successfully transfer from research to industry but remains a challenge. As many innovative medical devices are associated with or incorporate software, this article presents a methodology for evaluating the software maturity of a "Software-driven Medical Technology" (SdMT) during the research phase. A technological maturity model is developed by methodologically extracting relevant terms from the ISO/IEC 62304 standard, the main industry standard for medical device software, and results in a list of required software engineering artifacts. This list and the relative weight of the artifacts are used to establish a software maturity score for SdMT and the corresponding assessment questionnaire. The consistency of the model is demonstrated by analyzing the obtained score system relatively with the standard. The maturity score of a SdMT can be assessed during the research phase and depends on the number and importance of the artifacts already present at the time of evaluation.Clinical relevance- The proposed quantitative maturity score can help the medical technology innovation actors (clinicians, researchers and industrials) to better identify, improve and fasten the readiness of technology for clinical investigation and technology transfer.


Assuntos
Software , Tecnologia , Invenções , Transferência de Tecnologia , Indústrias
4.
5.
PLoS One ; 18(12): e0293951, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38096227

RESUMO

Technological innovation and preoccupation with new markets through technological innovation have become critical factors in achieving success in the global market. Currently, companies cannot develop and commercialize all technologies. Therefore, the importance of technology transfers is rapidly increasing. Technology transfer is a crucial strategy adopted by organizations to remain innovative and competitive. However, Korea's technology transfer rate is only 37.9%. In particular, the technology transfer rate from universities to companies is lower than that from government-funded research institutes in Korea. Although the fundamental approach for resolving barriers to technology transfer have been studied, previous research has been conducted from a narrow definition of technology transfer. Furthermore, previous research has focused on analyzing the success factors of technology transfer, presenting technology transfer processes, or conducting case studies. Therefore, it is necessary to develop a technology donor diagnosis framework based on CSFs (Critical Success Factors) to eliminate obstacles to technology transfers. To lower the barriers to technology transfers, it is necessary to develop a strategy for a successful technology transfer based on the diagnosis of technology donors. This study develops a diagnosis framework for universities from the perspective of technology donors, implements and tests the framework using case studies, and proposes strategies for each stage of technology transfer growth. The framework is able to assess multidimensional perspectives, because CSFs and PMs were extracted based on BSC. Furthermore, by comparing the perspectives score of technology donors in different universities, technology donors can identify the areas in which each university is lacking in its current situation. Multidimensional diagnosis and aggregation score of technology donors offer to extract optimal CSFs for technology transfer activation for each growth stage.


Assuntos
Transferência de Tecnologia , Tecnologia , Humanos , Universidades , Governo , Coreia (Geográfico)
6.
Vaccine ; 41(49): 7307-7312, 2023 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-37949751

RESUMO

The WHO/MPP mRNA Technology Transfer Programme, initiated in 2021, focuses on establishing mRNA vaccine manufacturing capacity in LMICs. On 17-21 April 2023, Programme partners were convened to review technology transfer progress, discuss sustainability aspects and promote mRNA product development for diseases relevant to LMICs. To help guide product development, this report introduces key considerations for for understanding the likelihood of technical and regulatory success and of policy development and procurement for mRNA vaccines to be developed and manufactured in LMICs. The report underscores the potential for LMICs to establish sustainable mRNA R&D pipelines.


Assuntos
Países em Desenvolvimento , Vacinas , Transferência de Tecnologia , Comércio , Organização Mundial da Saúde
7.
JAMA ; 330(17): 1615-1616, 2023 11 07.
Artigo em Inglês | MEDLINE | ID: mdl-37801311

RESUMO

In this Viewpoint a radiologist surveys the ascent of artificial intelligence (AI) in imaging and what the future likely holds for AI in this discipline.


Assuntos
Inteligência Artificial , Radiologia , Transferência de Tecnologia , Algoritmos , Tomada de Decisões Gerenciais
8.
Epidemiol Serv Saude ; 32(2): e2022614, 2023.
Artigo em Inglês, Português | MEDLINE | ID: mdl-37610938

RESUMO

MAIN RESULTS: Technology transfer can take place at large events, as long as safety protocols are strictly enforced. It is important to disseminate, at these events, the concepts of the Responsible Research and Innovation (RRI). Implications for services: Face-to-face training course is fundamental for training public health professionals. Technology transfer between research institutions and health services results in updating and improving health system performance. PERSPECTIVES: Based on the success of the reported technology transfer, a new module will be incorporated into the next edition of VEME (Panama 2022), entitled Virus Evolution to Public Health Policy Makers. The objective of this report was to describe the first face-to-face course aimed at training public health professionals in performing real-time genomic surveillance during the pandemic period. Experience report on a theoretical-practical course focusing on genomic research and surveillance, including mobile sequencing technologies, bioinformatics, phylogenetics and epidemiological modeling. There were 162 participants in the event and it was the first major face-to-face training course conducted during the COVID-19 epidemic in Brazil. No cases of SARS-CoV-2 infection was detected among the participants at the end of the event, suggesting the safety and effectiveness of all safety measures adopted. The results of this experience suggest that it is possible to conduct professional training safely during pandemics, as long as all safety protocols are followed.


Assuntos
COVID-19 , Educação Profissional em Saúde Pública , Transferência de Tecnologia , Humanos , Brasil/epidemiologia , COVID-19/epidemiologia , Pandemias , SARS-CoV-2 , Educação Profissional em Saúde Pública/métodos
12.
PLoS One ; 18(5): e0285431, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37205677

RESUMO

Prior studies ignore the impact of infrastructure on university technology transfer. High-speed rail, China's most significant infrastructure, has played an essential role in the economy and society. Using high-speed railway construction as a quasi-experiment and a large sample of Chinese universities for the 2007-2017 period, we investigate the impact of high-speed rail on university technology transfer. We provide extensive evidence that high-speed rail has a positive effect on university technology transfer. The finding remains valid after a battery of robustness tests. Mechanism tests find that high-speed rail can improve university technology transfer by promoting the interaction between universities and enterprises and improving enterprises' technology demand for universities. Further analysis shows that better intellectual property protection strengthens the effect of high-speed rail on university technology transfer, and the relationship between high-speed rail and university technology transfer is more prominent in the regions with underdevelopment technology trading markets. Our study suggests that high-speed rail is an important variable that affects university technology transfer.


Assuntos
Transferência de Tecnologia , Tecnologia , Humanos , Universidades , China
13.
AAPS PharmSciTech ; 24(4): 96, 2023 Apr 03.
Artigo em Inglês | MEDLINE | ID: mdl-37012545

RESUMO

Scale-up and transfer of lyophilization processes remain very challenging tasks considering the technical challenges and the high cost of the process itself. The challenges in scale-up and transfer were discussed in the first part of this paper and include vial breakage during freezing at commercial scale, cake resistance differences between scales, impact of differences in refrigeration capacities, and geometry on the performance of dryers. The second part of this work discusses successful and unsuccessful practices in scale-up and transfer based on the experience of the authors. Regulatory aspects of scale-up and transfer of lyophilization processes were also outlined including a topic on the equivalency of dryers. Based on an analysis of challenges and a summary of best practices, recommendations on scale-up and transfer of lyophilization processes are given including projections on future directions in this area of the freeze drying field. Recommendations on the choice of residual vacuum in the vials were also provided for a wide range of vial capacities.


Assuntos
Liofilização , Transferência de Tecnologia , Tecnologia Farmacêutica , Temperatura , Guias como Assunto
14.
PLoS One ; 18(3): e0283777, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36996173

RESUMO

Within the university-industry ecosystem, improvement and innovation of technology transfer involve implementing appropriate dynamic capabilities. To answer the question-What are the micro-foundations of dynamic capabilities in university technology transfer?-this study investigates in-depth organizational-level dynamic capabilities in transferring university-based knowledge to business and society. Two qualitative case studies were deployed at organizational entities at Vrije Universiteit Amsterdam: the Industry Alliance Office, and the Demonstrator Lab. These two organizations stimulate science- and business-oriented university technology transfer. In this context, the micro-foundations of the dynamic capabilities "sensing", "seizing" and "reconfiguring" are identified and discussed. For "sensing", which is the university's ability to explore the opportunities in the ecosystem, the micro-foundations are "selecting internal competency" and "sensing external partners". For "seizing", which supports universities in managing complementarity with industry and society, micro-foundations include "resource co-allocation" and "collaborative business model". The micro-foundations of "reconfiguring", through which universities maintain evolutionary fitness in the innovation ecosystem, are "strategic renewal", "establishing a university technology transfer-friendly environment", and "asset orchestration". This study provides researchers with a better understanding of how dynamic capabilities facilitate university technology transfer. Industrial practitioners and policymakers can consider the suggestions of the present study when pursuing collaboration with universities.


Assuntos
Ecossistema , Transferência de Tecnologia , Humanos , Universidades , Comércio , Indústrias
15.
PLoS One ; 18(3): e0282540, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36862740

RESUMO

Current research on the impact of innovation networks focuses on the web and inter-organizational layers, with less consideration of individual behavior at the firm level. Interaction is an active action strategy that firms take when dealing with the external environment. Therefore, this study explores the mechanism of enterprise interaction on innovation development from the perspective of an innovation network. And measures enterprise interaction in three dimensions: affective interaction, resource interaction, and management interaction. The empirical results indicate that the three dimensions of enterprise interaction contribute significantly to technological innovation performance, and the realization of this role requires technological innovation capabilities (technological research and development capabilities, technological commercialization capabilities) to play a partially mediating role. The moderating effect of absorptive capacity between resource interaction, management interaction, and technological innovation capability is significant; however, the moderating effect between affective interaction and technological innovation capability is statistically insignificant. This study promotes the development of interaction theory to a certain extent, which helps enterprises build appropriate industrial chains in innovation networks and achieve rapid development.


Assuntos
Invenções , Tecnologia , Indústrias , Transferência de Tecnologia
16.
Artigo em Inglês | MEDLINE | ID: mdl-36767318

RESUMO

The importance of studying civilization diseases manifests itself in the impact of changing lifestyles, on the number of deaths and causes of death. Technology transfer plays an important role in the prevention and treatment of these diseases. Through this, it is possible to transfer new treatments and diagnostics to clinics and hospitals more quickly and effectively, which leads to better healthcare for patients. Technology transfer can also aid in the development of new drugs and therapies that can be effective in the treatment of civilization diseases. The paper aims to evaluate the technology transfer process in the field of civilization diseases, using COVID-19 as an example of a pandemic that requires quick development and transfer of technology. To achieve the assumed goal, we propose a multivariate synthetic ratio in the field of civilization diseases (SMTT-Synthetic Measure of Technology Transfer) to analyze data from the Global Data database. We used sub-measures like SMTT_value (Synthetic Measure of Technology Transfer_value) and SMTT_quantity (Synthetic Measure of Technology Transfer_quantity) to measure technology transfer and put the data into a graph. Our analysis focuses on 14 diseases over a period of 10 years (2012-2021) and includes nine forms of technology transfer, allowing us to create a tool for analysing the process in multiple dimensions. Our results show that COVID-19 is similar in terms of technology transfer to diseases such as diabetes, cardiovascular diseases, neurodegenerative diseases, and breast cancer, even though data for COVID-19 is available for only 2 years.


Assuntos
COVID-19 , Transferência de Tecnologia , Humanos , COVID-19/epidemiologia , Causalidade , Estilo de Vida , Civilização
17.
Biotechnol Prog ; 39(1): e3306, 2023 01.
Artigo em Inglês | MEDLINE | ID: mdl-36264017

RESUMO

Biologics manufacturing is capital and consumable intensive with need for advanced inventory planning to account for supply chain constraints. Early-stage process design and technology transfer are often challenging due to limited information on process variability regarding bioreactor titer, process yield, and product quality. Monte Carlo (MC) methods offer a stochastic modeling approach for process optimization where probabilities of occurrence for process inputs are incorporated into a deterministic model to simulate more likely scenarios for process outputs. In this study, we explore MC simulation-based design of a monoclonal antibody downstream manufacturing process. We demonstrate that this probabilistic approach offers more representative outcomes over the conventional worst-case approach where the theoretical minimum and maximum values of each process parameter are used without consideration for their probability of occurrence. Our work demonstrates case studies on more practically sizing unit operations to improve consumable utilization, thereby reducing manufacturing costs. We also used MC simulations to minimize process cadence by constraining the number of cycles per unit operation to fit facility preferences. By factoring in process uncertainty, we have implemented MC simulation-based facility fit analyses to efficiently plan for inventory when accounting for process constraints during technology transfer from lab-scale to clinical or commercial manufacturing.


Assuntos
Reatores Biológicos , Transferência de Tecnologia , Método de Monte Carlo , Simulação por Computador , Anticorpos Monoclonais
18.
Sci Total Environ ; 857(Pt 3): 159510, 2023 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-36257415

RESUMO

Air pollution hinders technological innovation, but the causal effects of air pollution on technology transfer are overlooked. We use thermal inversion as an instrumental variable for addressing air pollution endogeneity. The empirical results show that a one-unit increase in air pollution reduces technology transfer strength by 4.5 %. However, air pollution has a strong asymmetry in two directions of technology transfer strength. We find that those cities with worse pollution have an intention to transfer their technologies to cities in other provinces. In the PLFC model, heterogeneity varying with GDP can be addressed to estimate the marginal effect between them. Findings suggest that the marginal effects of air pollution on technology transfer can be divided into two parts based on GDP levels. Within the thresholds (lngdp = 11), the effect of environmental regulations will keep increasing and keep stable beyond the thresholds. In addition, different effects on different cities are also discussed.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Cidades , Poluentes Atmosféricos/análise , Transferência de Tecnologia , Poluição do Ar/prevenção & controle , Poluição do Ar/análise , China , Material Particulado/análise
19.
Acta Medica Philippina ; : 70-76, 2023.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-980448

RESUMO

@#Necessity motivates innovators in low- to middle-income countries (LMICs) to develop medical devices that solve unmet local health needs. At the start of each process, multidisciplinary teams incubate ideas. Design planning and validation require funding, infrastructure, procurement, and testing. Ultimately, the regulatory and technology transfer processes usher the technology to market. These stages are standard procedures in developed nations; in an LMIC, these present a new set of hurdles to overcome. To assist innovators, this paper describes the hurdles from ideation to regulation and technology transfer and delineates mechanisms to address them.


Assuntos
Equipamentos e Provisões , Tecnologia Biomédica , Transferência de Tecnologia
20.
Biosensors (Basel) ; 12(12)2022 Nov 29.
Artigo em Inglês | MEDLINE | ID: mdl-36551058

RESUMO

Despite the remarkable development related to Point-of-Care devices based on optical technology, their difficulties when used outside of research laboratories are notable. In this sense, it would be interesting to ask ourselves what the degree of transferability of the research work to the market is, for example, by analysing the relation between the scientific work developed and the registered one, through patent. In this work, we provide an overview of the state-of-the-art in the sector of optical Point-of-Care devices, not only in the research area but also regarding their transfer to market. To this end, we explored a methodology for searching articles and patents to obtain an indicator that relates to both. This figure of merit to estimate this transfer is based on classifying the relevant research articles in the area and the patents that have been generated from these ones. To delimit the scope of this study, we researched the results of a large enough number of publications in the period from 2015 to 2020, by using keywords "biosensor", "optic", and "device" to obtain the most representative articles from Web of Science and Scopus. Then, we classified them according to a particular classification of the optical PoC devices. Once we had this sampling frame, we defined a patent search strategy to cross-link the article with a registered patent (by surfing Google Patents) and classified them accordingly to the categories described. Finally, we proposed a relative figure called Index of Technology Transference (IoTT), which estimates to what extent our findings in science materialized in published articles are protected by patent.


Assuntos
Sistemas Automatizados de Assistência Junto ao Leito , Transferência de Tecnologia , Biotecnologia
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