Studying the Humoral Response against SARS-CoV-2 in Cuban COVID-19 Recovered Patients.

Understanding the immune response generated by SARS-CoV-2 is critical for assessing efficient therapeutic protocols and gaining insights into the durability of protective immunity. The current work was aimed at studying the specific humoral responses against SARS-CoV-2 in Cuban COVID-19 convalescents. We developed suitable tools and methods based on ELISA methodology, for supporting this evaluation. Here, we describe the development of an ELISA for the quantification of anti-RBD IgG titers in a large number of samples and a similar test in the presence of NH4SCN as chaotropic agent for estimating the RBD specific antibody avidity. Additionally, a simple and rapid ELISA based on antibody-mediated blockage of the binding RBD-ACE2 was implemented for detecting, as a surrogate of conventional test, the levels of anti-RBD inhibitory antibodies in convalescent sera. In a cohort of 273 unvaccinated convalescents, we identified higher anti-RBD IgG titer (1 : 1,330, p < 0.0001) and higher levels of inhibitory antibodies blocking RBD-ACE2 binding (1 : 216, p < 0.05) among those who had recovered from severe illness. Our results suggest that disease severity, and not demographic features such as age, sex, and skin color, is the main determinant of the magnitude and neutralizing ability of the anti-RBD antibody response. An additional paired longitudinal assessment in 14 symptomatic convalescents revealed a decline in the antiviral antibody response and the persistence of neutralizing antibodies for at least 4 months after the onset of symptoms. Overall, SARS-CoV-2 infection elicits different levels of antibody response according to disease severity that declines over time and can be monitored using our homemade serological assays.

Maniobras de vacunación contra la Covid-19 en Songo-La Maya, Cuba / Vaccination maneuvers against Covid-19 in Songo-La Maya, Cuba / Medidas de vacinação contra a Covid-19 em Songo-La Maya, Cuba

Introducción: En la lucha contra las epidemias la vacunación resulta una herramienta indispensable de la salud pública. Método: Se presenta una investigación interventiva y del tipo descriptivo, no experimental y bajo los métodos: observación participativa, revisión de historias clínicas, entrevista médica y correlación de datos. El universo y muestra estuvo constituido por 87 028 personas mayores de 2 años de edad pertenecientes al municipio Songo-La Maya. Se implementó la vacunación en el periodo Febrero del 2021 hasta Febrero del 2022. Todo bajo la metodología de la investigación cuantitativa y del paradigma del positivismo. Resultados: al cierre de febrero del 2022 se administraron 270140 dosis de las vacunas cubanas Abdala, soberana 02, soberana plus y 951 dosis de vacuna china Sinopharm; para un total de 271091 dosis administradas. Hasta la fecha, han recibido al menos una dosis de una de las vacunas cubanas 75 866 personas. Conclusiones: En el municipio Songo-La Maya hasta febrero del 2022, el 78.02 % de su población quedó inmunizada contra la Covid-19. Más de la mitad (58,14%) completaron el esquema de las 3 dosis de la vacuna Abdala y el 17,75% completó el esquema de la 2da dosis de soberana 02 y una de soberana plus. Es notorio que en las publicaciones de los medios que responden a los países altamente industrializados no mencionan las vacunas cubanas, esto puede responder a mediaciones políticas para no dar méritos a los logros de la Revolución Cubana.

Introduction: In the fight against epidemics, vaccination is an indispensable public health tool. Method: An interventional and descriptive research is presented, non-experimental and using the methods: participatory observation, review of medical record, medical interview and data correlation. The universe and sample consisted of 87,028 people over 2 years of age belonging to the Songo-La Maya municipality. Vaccination was implemented in the period from February 2021 to February 2022. All under the methodology of quantitative research and the paradigm of positivism. Results: at the end of February 2022, 270,140 doses of the Cuban vaccines Abdala, sovereign 02, sovereign plus and 951 doses of the Chinese Sinopharm vaccine were administered; for a total of 271,091 doses administered. To date, 75,866 people have received at least one dose of one of the Cuban vaccines. Conclusions: In the Songo-La Maya municipality until February 2022, 78.02% of its population was immunized against Covid-19. More than half (58.14%) completed the schedule of the 3 doses of the Abdala vaccine and 17.75% completed the schedule of the 2nd dose of sovereign 02 and one of sovereign plus. It is notorious that in media publications that respond to highly industrialized countries they do not mention Cuban vaccines; this may respond to political mediations to not give merit to the achievements of the Cuban Revolution.

Introdução: No combate às epidemias, a vacinação é uma ferramenta indispensável de saúde pública. Método: Apresenta-se uma pesquisa intervencionista e descritiva, não experimental e utilizando os métodos: observação participante, revisão de prontuários, entrevista médica e correlação de dados. O universo e a amostra foram constituídos por 87.028 pessoas com mais de 2 anos pertencentes ao município de Songo-La Maya. A vacinação foi implementada no período de fevereiro de 2021 a fevereiro de 2022. Tudo sob a metodologia da pesquisa quantitativa e o paradigma do positivismo. Resultados: no final de fevereiro de 2022, foram administradas 270.140 doses das vacinas cubanas Abdala, soberana 02, soberana plus e 951 doses da vacina chinesa Sinopharm; para um total de 271.091 doses administradas. Até o momento, 75.866 pessoas receberam pelo menos uma dose de uma das vacinas cubanas. Conclusões: No município de Songo-La Maya até Fevereiro de 2022, 78,02% da sua população estava imunizada contra a Covid-19. Mais da metade (58,14%) completou o esquema das 3 doses da vacina Abdala e 17,75% completou o esquema da 2ª dose da soberana 02 e uma da soberana plus. É notório que nas publicações mediáticas que respondem aos países altamente industrializados não mencionam as vacinas cubanas; isto pode responder às mediações políticas para não dar mérito às conquistas da Revolução Cubana.

Real-world effectiveness of the heterologous SOBERANA-02 and SOBERANA-Plus vaccine scheme in 2-11 years-old children during the SARS-CoV-2 Omicron wave in Cuba: a longitudinal case-population study.

Background: Increased pediatric COVID-19 occurrence due to the SARS-CoV-2 Omicron variant has raised concerns about the effectiveness of existing vaccines. The protection provided by the SOBERANA-02-Plus vaccination scheme against this variant has not yet been studied. We aimed to evaluate the scheme's effectiveness against symptomatic Omicron infection and severe disease in children. Methods: In September 2021, Cuba implemented a mass pediatric immunization with the heterologous SOBERANA-02-Plus scheme: 2 doses of conjugated SOBERANA-02 followed by a heterologous SOBERANA-Plus dose. By December, before the Omicron outbreak, 95.4% of 2-18 years-old had been fully immunized. During the entire Omicron wave, we conducted a nationwide longitudinal post-vaccination case-population study to evaluate the real-world effectiveness of the SOBERANA-02-Plus scheme against symptomatic infection and severe disease in children without previous SARS-CoV-2 infection. The identification of COVID-19 cases relied on surveillance through first line services, which refer clinical suspects to pediatric hospitals where they are diagnosed based on a positive RT-PCR test. We defined the Incidence Rate ratio (IRR) as IRvaccinated age group/IRunvaccinated 1-year-old and calculated vaccine effectiveness as VE = (1-IRR)∗100%. 24 months of age being the 'eligible for vaccination' cut-off, we used a regression discontinuity approach to estimate effectiveness by contrasting incidence in all unvaccinated 1-year-old versus vaccinated 2-years-old. Estimates in the vaccinated 3-11 years-old are reported from a descriptive perspective. Findings: We included 1,098,817 fully vaccinated 2-11 years-old and 98,342 not vaccinated 1-year-old children. During the 24-week Omicron wave, there were 7003/26,241,176 person-weeks symptomatic COVID-19 infections in the vaccinated group (38.2 per 105 person-weeks in 2-years-old and 25.5 per 105 person-weeks in 3-11 years-old) against 3577/2,312,273 (154.7 per 105 person-weeks) in the unvaccinated group. The observed overall vaccine effectiveness against symptomatic infection was 75.3% (95% CI, 73.5-77.0%) in 2-years-old children, and 83.5% (95% CI, 82.8-84.2%) in 3-11 years-old. It was somewhat lower during Omicron BA.1 then during Omicron BA.2 variant circulation, which took place 1-3 and 4-6 months after the end of the vaccination campaign. The effectiveness against severe symptomatic disease was 100.0% (95% CI not estimated) and 94.6% (95% CI, 82.0-98.6%) in the respective age groups. No child death from COVID-19 was observed. Interpretation: Immunization of 2-11 years-old with the SOBERANA-02-Plus scheme provided strong protection against symptomatic and severe disease caused by the Omicron variant, which was sustained during the six months post-vaccination follow-up. Our results contrast with the observations in previous real-world vaccine effectiveness studies in children, which might be explained by the type of immunity a conjugated protein-based vaccine induces and the vaccination strategy used. Funding: National Fund for Science and Technology (FONCI-CITMA-Cuba).

Temephos Resistance Status of Aedes aegypti Populations From Havana, Cuba.

Aedes aegypti chemical control remains an indispensable alternative to prevent dengue, Zika, and chikungunya outbreaks in Havana, Cuba. The city of Havana requires constant surveillance because of its bioecological characteristics that favor the proliferation of mosquito vectors of these viruses, which constitutes a high risk to the health of its inhabitants. The goal of this study was to determine the impact of the stopping of temephos applications during the 2 years of the COVID-19 pandemic on the level of susceptibility of Ae. aegypti in 5 municipalities of Havana, Cuba. Larval susceptibility was evaluated by bioassays as described by the World Health Organization. All Ae. aegypti populations tested showed high resistance to temephos. The National Control Program of Ae. aegypti in Cuba will need to promote insecticide rotation policies to prevent the evolution of temephos resistance in Havana.

Caracterización genética de aislamientos de SARS-CoV-2 en las diferentes etapas pandémicas de COVID-19 en Cuba

Introducción: El desarrollo de vacunas seguras y eficaces contra el SARS-CoV-2 supuso un enorme reto para enfrentar la pandemia de la COVID-19. La aparición de nuevas variantes del SARS-CoV-2 representa un reto en la evaluación de la efectividad de las vacunas, diferentes candidatos vacunales y terapéuticos desarrollados por la comunidad científica. Objetivos: Caracterizar la diversidad genética de aislamientos virales cubanos en el periodo comprendido entre junio de 2020 y diciembre de 2022. Métodos: Se obtuvo el ARN de SARS-CoV-2 de 27 aislamientos a partir de sobrenadante de cultivo celular y se secuenció el gen S. Las secuencias generadas se emplearon para la identificación y posterior caracterización molecular de las variantes genéticas del virus mediante análisis filogenético y el uso de las herramientas disponibles en la base de datos GISEAD. Resultados: Las variantes detectadas en los aislamientos cubanos de SARS-CoV-2 estudiados se correspondieron a las identificadas en los estudios de vigilancia genómica realizados en las diferentes etapas pandémicas de la COVID-19 en Cuba. El 33,3 % de los aislamientos secuenciados correspondieron a los diferentes linajes de la variante Ómicron, seguido de la variante Beta B 1.351 (29,6 %), otros linajes de SARS-CoV-2 (25,9 %), Alfa B 1.1.7 (7,4 %) y Delta B.1.575 (3,7 %). Se detectó la mutación D614G en todos los aislamientos de SARS-CoV-2 estudiados. Conclusiones: La caracterización molecular de los aislamientos cubanos de SARS-CoV-2 tiene una elevada diversidad genética. Posibilita evaluar in vitro e in vivo los candidatos vacunales y agentes terapéuticos desarrollados por la industria biofarmacéutica cubana.

Introduction: The development of safe and effective vaccines against SARS-CoV-2 posed a huge challenge to face the COVID-19 pandemic. The appearance of new variants of SARS-CoV-2 represents a challenge in evaluating the effectiveness of vaccines, different vaccine and therapeutic candidates developed by the scientific community. Objectives: Characterize and analyze the genetic diversity of Cuban viral isolates, in the period between June 2020 and December 2022. Methods: SARS-CoV-2 RNA was obtained from 27 isolates from cell culture supernatant and the S gene was sequenced. The generated sequences were used for the identification and subsequent molecular characterization of the genetic variants of the virus through phylogenetic analysis and the use of the tools available in the GISEAD database. Results: The variants detected in the Cuban SARS-CoV-2 isolates corresponded to those identified in the genomic surveillance studies carried out in the different stages of the COVID-19 pandemic in Cuba. 33.3% of the sequenced isolates corresponded to the different lineages of the Omicron variant, followed by Beta B 1.351 (29.6%), other SARS-CoV-2 lineages (25.9%), Alpha B 1.1.7 (7.4%) and Delta B.1.575 (3.7%). The D614G mutation was detected in all SARS-CoV-2 isolates studied. Conclusions: The molecular characterization of the Cuban isolates of SARS-CoV-2 has a high genetic diversity. It makes it possible to evaluate in vitro and in vivo vaccine candidates and therapeutic agents developed by the Cuban biopharmaceutical industry.

Resolutividad del tratamiento con Jusvinza en pacientes confirmados de COVID-19. Santiago de Cuba, 2021

Fundamento la infección por SARS-CoV-2 es la enfermedad emergente más importante del presente siglo. En dicho contexto, el Grupo de las Industrias Biotecnológica y Farmacéutica Cubanas (BioCubaFarma) creó alternativas terapéuticas para combatir la COVID-19, entre ellas el uso de Jusvinza, la cual forma parte del protocolo utilizado en el país. Objetivo determinar la resolutividad terapéutica de Jusvinza en pacientes confirmados de COVID-19. Métodos se realizó un estudio descriptivo, durante el periodo de enero a septiembre de 2021, en el Hospital Militar Dr. Joaquín Castillo Duany, de Santiago de Cuba. El universo estuvo constituido por 166 confirmados de COVID-19, a quienes se administró Jusvinza. Se analizaron algunas variables clínicas (estado clínico, enfermedades no transmisibles asociadas, progresión clínica), epidemiológicas (edad, sexo) y farmacológicas (resolutividad, duración en días). Se utilizó una planilla de vaciamiento de datos, los cuales fueron tomados de las historias clínicas. Resultados la morbimortalidad por COVID-19 fue superior en el sexo masculino, asociado a comorbilidades y edad mayor de 60 años; el sexo femenino resultó el de mayor resolutividad al tratamiento con Jusvinza (71,7 %), la cual incrementó su porcentaje en ausencia de enfermedades crónicas no transmisibles asociadas (81,4 %). Los pacientes de alto riesgo fueron los de más baja mortalidad (15,8 %). Conclusiones la resolutividad en pacientes confirmados de COVID-19 tratados con Jusvinza fue más elevada en casos de alto riesgo que en graves y críticos.

Foundation SARS-CoV-2 infection is the most important emerging disease of this century. In this context, the Cuban Biotechnology and Pharmaceutical Industries Group (BioCubaFarma) created therapeutic alternatives to combat COVID-19, including the use of Jusvinza, which is part of the protocol used in the country. Objective to determine the Jusvinza therapeutic resolution in confirmed COVID-19 patients. Methods a descriptive study carried out from January to September 2021, at the Dr. Joaquín Castillo Duany Military Hospital, in Santiago de Cuba. The universe consisted of 166 confirmed COVID-19 cases, to whom Jusvinza was administered. Some clinical variables (clinical status, associated non-communicable diseases, clinical progression), epidemiological (age, sex) and pharmacological (resolving, duration in days) were analyzed. A data extraction form was used, which was taken from the medical records. Results morbidity and mortality from COVID-19 was higher in males, related to comorbidities and age over 60 years; The female sex was the one with the greatest response to treatment with Jusvinza (71.7%), which increased its percentage in the absence of associated chronic non-communicable diseases (81.4%). High-risk patients had the lowest mortality (15.8%). Conclusions resolution in confirmed COVID-19 patients treated with Jusvinza was higher in high-risk cases than in severe and critical cases.

Tratamiento de las fracturas maxilofaciales en un hospital cubano durante la pandemia de COVID-19

Introducción: La epidemiología de las fracturas maxilofaciales varía en dependencia de los estilos de vida, el nivel cultural y el estatus socioeconómico en diferentes zonas geográficas. Objetivo: Caracterizar epidemiológica y terapéuticamente a los pacientes con fracturas maxilofaciales, atendidos en un hospital universitario cubano durante la pandemia de COVID-19. Métodos: Se realizó un estudio observacional, descriptivo y transversal a los pacientes atendidos en el Servicio de Cirugía Maxilofacial del Hospital General Universitario "Carlos Manuel de Céspedes" de Bayamo, provincia Granma, durante el 1 de enero y el 31 de diciembre de 2020. Se estudiaron variables epidemiológicas y terapéuticas. Resultados: Se incluyeron 85 pacientes con 220 fracturas. Los hombres fueron los más afectados (n = 74; 87,06 %) y la proporción hombre/mujer resultó de 6,73:1. El grupo etario de 41-60 años (n = 40; 47,06 %) sobresalió. En el 38,89 % de los casos el trauma se relacionó con violencia interpersonal. Cincuenta y cuatro pacientes (63,52 %) tuvieron fracturas del complejo cigomático. El ángulo mandibular constituyó la localización anatómica más afectada. Las fracturas mandibulares se trataron fundamentalmente mediante reducción cerrada. Conclusiones: El perfil epidemiológico de las fracturas maxilofaciales se destacó en los pacientes adultos masculinos debido, principalmente, a la violencia interpersonal. Las fracturas complejas del tercio medio facial se trataron por método abierto. La distribución temporal de los casos mostró el impacto de la COVID-19 en la epidemiología de estos traumas.

Introduction: The epidemiology of maxillofacial fractures varies according to lifestyles, cultural level and socioeconomic status in different geographical areas. Objective: To characterize epidemiologically and therapeutically the patients with maxillofacial fractures treated in a Cuban university hospital during the COVID-19 pandemic. Methods: An observational, descriptive and cross-sectional study was carried out on patients attended at the Maxillofacial Surgery Service of the General University Hospital "Carlos Manuel de Céspedes" of Bayamo, Granma province, between January 1 and December 31, 2020. Epidemiological and therapeutic variables were studied. Results: 85 patients with 220 fractures were included. Men were the most affected (n = 74; 87.06 %) and the male/female ratio was 6.73:1. The age group 41-60 years (n = 40; 47.06 %) stood out. In 38.89 % of the cases the trauma was related to interpersonal violence. Fifty-four patients (63.52 %) had fractures of the zygomatic complex. The mandibular angle was the most damaged anatomical location. Fractures were treated primarily by closed reduction. Conclusions: The epidemiological profile of maxillofacial fractures was prominent in adult male patients mainly due to interpersonal violence. Complex fractures of the midfacial third were treated by open method. The temporal distribution of the cases showed the impact of COVID-19 on the epidemiology of these traumas.

Manifestaciones orales en pacientes cubanos con COVID-19 hospitalizados y no hospitalizados: Análisis transversal a través de una encuesta / Oral Manifestations in Hospitalized and Non-Hospitalized Cuban Patients with COVID-19: A Cross-Sectional Analysis through a Survey

Introduction: COVID-19 continues to drive research aimed at elucidating the disease's behavior and clinical aspects for improved diagnosis. Objective: To describe oral manifestations reported through a survey by dentate and denture-wearing Cuban individuals hospitalized due to confirmed COVID-19 infection. Methods: A cross-sectional descriptive study was conducted through a survey, involving Cuban individuals aged 18 years and above, confirmed COVID-19 positive by PCR. Exclusions encompassed smokers, alcoholics, regular medication users, those with poor oral hygiene, and individuals with pre-existing oral manifestations. A questionnaire was administered to over a thousand individuals, of which 264 met the criteria. Variables related to COVID-19 infection and oral hygiene were assessed. Data were processed using SPSS, adhering to ethical principles. Results: The study comprised 264 participants with an average age of 39.96 years. Xerostomia emerged as the most prevalent oral manifestation (40.2 por ciento), followed by mandibular pain, TMJ, or bone pain (18.9 por ciento), and non-dental mouth pain (12.5 por ciento). Xerostomia was more prevalent in the 35 to 39 age group, while mandibular pain predominated in the 50 to 54 age group. No statistically significant evidence was found for dentate individuals or denture wearers, but significance was observed for those requiring hospitalization, exhibiting painless tongue lesions, single ulcers, and painful tongue lesions. Conclusions: Xerostomia was the most prevalent oral manifestation, followed by mandibular pain, TMJ or bone pain, and non-dental mouth pain. A statistically significant association was noted between the need for hospitalization and certain oral manifestations. The use of dentures was not significantly related to the studied manifestations(AU)

Introducción: La COVID-19 continúa generando interés en investigaciones que buscan esclarecer el comportamiento de la enfermedad y sus aspectos clínicos para facilitar el diagnóstico. Objetivo: Describir las manifestaciones orales informadas por individuos cubanos dentados, con prótesis, que fueron hospitalizados al dar positivo por COVID-19. Métodos: Se llevó a cabo un estudio descriptivo transversal a través de una encuesta con una muestra de individuos cubanos mayores de 18 años, infectados por COVID-19 y confirmados mediante PCR. Se excluyeron fumadores, alcohólicos, usuarios regulares de medicamentos, personas con mala higiene bucal y aquellos con manifestaciones bucales previas a la infección. Se aplicó un cuestionario a más de mil individuos, de los cuales 264 cumplieron con los criterios. Se utilizaron variables relacionadas con la infección por COVID-19 y la higiene bucal. Los datos se procesaron con SPSS, respetando los principios éticos. Resultados: El estudio incluyó a 264 participantes con una edad promedio de 39,96 años. La xerostomía fue la manifestación bucal más prevalente (40,2 percent), seguida por el dolor mandibular, ATM o hueso (18,9 percent) y el dolor de boca no dental (12,5 percent). La xerostomía fue más frecuente en el grupo de 35 a 39 años, mientras que el dolor mandibular predominó en el grupo de 50 a 54 años. No se encontró evidencia estadística significativa para pacientes dentados o portadores de prótesis, pero sí para aquellos que necesitaron hospitalización, con lesiones en la lengua sin dolor, úlceras únicas y lesiones en la lengua con dolor. Conclusiones: La xerostomía fue la manifestación bucal más prevalente, seguida por el dolor mandibular, ATM o hueso, y el dolor de boca no dental. Se observó una asociación estadísticamente significativa entre la necesidad de hospitalización y ciertas manifestaciones bucales. No se encontró significativo el uso de prótesis en relación con las manifestaciones estudiadas(AU)

La educación bioética en revistas cubanas de salud indexadas en Scielo

La educación bioética se erige como cuestión ineludible en el campo de las ciencias de la salud ante los avances de la tecnociencia y el desarrollo humano. Se realizó una investigación descriptiva transversal, con el propósito de analizar la divulgación científica sobre educación bioética aportada por las revistas cubanas de salud indexadas en Scielo, en el periodo 2020-2022. Fueron consultados los sitios Scielo y Google académico, se consideraron los términos de búsqueda: bioética, educación bioética, enseñanza bioética. En el análisis se incluyeron las variables título, año, número de artículos, producción por revistas, país de procedencia, tipología, número de autores, distribución por ejes temáticos y número de citaciones. La muestra quedó constituida por 21 trabajos. La contribución de artículos sobre el tema mostró un comportamiento discreto. La mayor producción se situó en el año 2022. Predominaron los trabajos realizados por autores cubanos, en la tipología de artículos de revisión (28,5%) y desarrollados en coautoría. El eje temático orientado a la atención en los principios bioéticos, los derechos de pacientes y el consentimiento informado fue el más abordado (38,1%), seguido de la educación bioética ante los desafíos generados por la COVID-19, que concentró el mayor número de citaciones. Los resultados develan un reto investigativo que requiere ampliar el tratamiento del tema con experiencias enriquecedoras que logren trascender en la comunidad científica.

Bioethical education stands as an unavoidable issue in the field of health sciences in the face of advances in technoscience and human development. A cross-sectional descriptive research was carried out with the purpose of analyzing the scientific dissemination on bioethics education provided by the Cuban health magazines indexed in Scielo in the period 2020-2022. The Scielo and Google academic sites were consulted, the search terms were considered: bioethics, bioethics education, bioethics teaching. The variables title, year, number of articles, production by journals, country of origin, typology, number of authors, distribution by thematic axes and number of citations were included in the analysis. The sample consisted of 21 works. The contribution of articles on the topic showed a discreet behavior. The highest production was in 2022. The works carried out by Cuban authors predominated, in the typology of review articles (28.5%) and developed in co-authorship. The thematic axis focused on attention to bioethical principles, patient rights and informed consent was the most addressed (38.1%) followed by bioethical education in the face of the challenges generated by COVID-19, which concentrated the largest number. of citations. The results reveal a research challenge that requires expanding the treatment of the topic with enriching experiences that can transcend the scientific community.

A educação em bioética coloca-se como uma questão incontornável no campo das ciências da saúde frente aos avanços da tecnociência e do desenvolvimento humano. Realizou-se uma pesquisa descritiva transversal com o objetivo de analisar a divulgação científica sobre educação bioética proporcionada pelas revistas cubanas da área da saúde indexadas na Scielo no período 2020-2022. Foram consultados os sites Scielo e Google Acadêmico, considerados os termos de busca: bioética, educação em bioética, ensino em bioética. As seguintes variáveis foram incluídas na análise: título, ano, número de artigos, produção por periódicos, país de origem, tipologia, número de autores, distribuição por eixos temáticos e número de citações. A amostra constituiu-se de 21 trabalhos. O A contribuição de artigos sobre o tema mostrou um comportamento discreto. A maior produção foi em 2022. Predominaram obras de autores. ubanos, na tipologia de artigos de revisão (28,5%) e desenvolvidos em coautoria. O eixo temático voltado para a atenção aos princípios bioéticos, direitos do paciente e consentimento informado foi o mais abordado (38,1%), seguido pela educação em bioética frente aos desafios gerados pela Covid-19, que concentrou o maior número de citações. Os resultados revelam um desafio de pesquisa que requer ampliar o tratamento do tema com experiências enriquecedoras que conseguem transcender na comunidade científica.