Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
Acta cir. bras
; 34(4): e201900404, 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1001088
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Purpose:
To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods.Methods:
Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours.Results:
Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group.Conclusion:
The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Quercetina
/
Traumatismo por Reperfusão
/
Anti-Inflamatórios não Esteroides
/
Mucosa Gástrica
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Amasya University/TR
/
Ataturk University/TR
/
Erzincan Binali Yildirim University/TR
/
Mengücek Gazi Training and Research Hospital/TR
/
Zile State Hospital/TR