Influence of tumour condition on the Macrophage Activity in Candida albicans infection
Oxford; s.n; 2009. 8 p. graf.
Não convencional
em Inglês
| Sec. Est. Saúde SP, SESSP-ILSLPROD, Sec. Est. Saúde SP, SESSP-ILSLACERVO, Sec. Est. Saúde SP
| ID: biblio-1007446
Biblioteca responsável:
BR191.1
Localização: BR191.1; 9464/S
ABSTRACT
To better understand the interactions between opportunistic fungi and their hosts, we investigated hydrogen peroxide (H2O2), nitric oxide and TNF-alpha production by peritoneal macrophages from Ehrlich tumour-bearing mice (TBM) during microbial infections. For this purpose, TBM at days 7, 14 and 21 of tumour progression were inoculated intraperitoneally with C. albicans and evaluated after 24 and 72 h. We observed that TBM showed significant increases in H2O2, TNF-alpha levels and fungal clearance at day 7 after C. albicans infection. However, as the tumour advanced, there was a progressive decline in the release of H2O2 and TNF-alpha that was paired with the dissemination of C. albicans. These results demonstrate that protective macrophage activities against Candida albicans are limited to the initial stages of tumour growth; continued solid tumour growth weakened the macrophage response and as a consequence, weakened the host's susceptibility to opportunistic infections
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-ILSLACERVO
/
SESSP-ILSLPROD
Assunto principal:
Infecções Oportunistas
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Candida albicans
/
Candidíase
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Carcinoma de Ehrlich
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Linfotoxina-alfa
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Macrófagos Peritoneais
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Peróxido de Hidrogênio
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Óxido Nítrico
Limite:
Animais
Idioma:
Inglês
Ano de publicação:
2009
Tipo de documento:
Não convencional