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High-grade B-Cell lymphoma with MYC and BCL6 rearrangements associated with Richter transformation of chronic lymphocytic leukemia
Rogers, Thomas S; Gardner, Juli-Anne; Devitt, Katherine A.
Afiliação
  • Rogers, Thomas S; University of Vermont Medical Center. University of Vermont. Department of Pathology and Laboratory Medicine. Burlington. US
  • Gardner, Juli-Anne; University of Vermont Medical Center. University of Vermont. Department of Pathology and Laboratory Medicine. Burlington. US
  • Devitt, Katherine A; University of Vermont Medical Center. University of Vermont. Department of Pathology and Laboratory Medicine. Burlington. US
Autops. Case Rep ; 9(3): e2019090, July-Sept. 2019. ilus, graf
Article em En | LILACS | ID: biblio-1020995
Biblioteca responsável: BR26.7
ABSTRACT
Richter transformation (RT), or Richter syndrome, is defined as the transformation of chronic lymphocytic leukemia (CLL) to an aggressive B-cell lymphoma. The vast majority, up to 99%, transform into diffuse large B-cell lymphoma (DLBCL), with a small subset (<1%) becoming classical Hodgkin lymphoma. Approximately half of RT cases progress through a pathway involving dysregulation of C-MYC. High-grade B-cell lymphoma (HGBL) is a recent diagnostic category of aggressive B-cell lymphomas set forth in the updated 2017 WHO Classification of Hematopoietic and Lymphoid Tissues. HGBL with MYC and BCL2 and/or BCL6 rearrangements, formerly "double-hit" and "triple-hit" lymphomas, comprise the majority of HGBL cases. Patients with HGBL have a worse prognosis than those with diffuse large B-cell lymphoma. We present a case of RT with rearrangements of MYC and BCL6. To our knowledge, there are no reported cases of RT with a "double-hit" lymphoma genotype.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Linfoma Difuso de Grandes Células B Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Autops. Case Rep Assunto da revista: Anatomia / Patologia Cl¡nica / Patologia Legal Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Linfoma Difuso de Grandes Células B Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Revista: Autops. Case Rep Assunto da revista: Anatomia / Patologia Cl¡nica / Patologia Legal Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil