Strong sex bias in elite control of paediatric HIV infection
AIDS
; 33(1): 67-75, Jan. 2019. ilus, tab
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IIERPROD, Sec. Est. Saúde SP
| ID: biblio-1021225
Biblioteca responsável:
BR31.1
Localização: BR31.1; 2019_P-002
ABSTRACT
BACKGROUND:
Reports of posttreatment control following antiretroviral therapy (ART) have prompted the question of how common immune control of HIV infection is in the absence of ART. In contrast to adult infection, where elite controllers have been very well characterized and constitute approximately 0.5% of infections, very few data exist to address this question in paediatric infection.METHODS:
We describe 11 ART-naive elite controllers from 10 cohorts of HIV-infected children being followed in South Africa, Brazil, Thailand, and Europe.RESULT:
All but one of the elite controllers (91%) are females. The median age at which control of viraemia was achieved was 6.5 years. Five of these 11 (46%) children lost control of viraemia at a median age of 12.9 years. Children who maintained control of viraemia had significantly higher absolute CD4þ cell counts in the period of elite control than those who lost viraemic control. On the basis of data available from these cohorts, the prevalence of elite controllers in paediatric infection is estimated to be 510-fold lower than in adults.CONCLUSION:
Although conclusions are limited by the study design, these data suggest that, whilst paediatric elite control can be achieved, compared with adult elite controllers, this occurs rarely, and takes some years after infection to achieve. Also, loss of immune control arises in a high proportion of children and often relatively rapidly. These findings are consistent with the more potent antiviral immune responses observed in adults and in females
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
/
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IIERPROD
Assunto principal:
Infecções por HIV
/
Terapia Antirretroviral de Alta Atividade
Tipo de estudo:
Fatores de risco
Limite:
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
AIDS
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
AIDS Research Institute/ES
/
Center of Excellence for Pediatric Infectious Diseases and Vaccines/TH
/
Chulalongkorn University/TH
/
Great Ormond Street Hospital for Children/GB
/
Great Ormond Street Hospital for Children/GB
/
Imperial College/GB
/
Karolinska Institute/SE
/
Kimberley Hospital/ZA
/
Secretaria de Estado da Saúde. São Paulo/BR
/
Stellenbosch University/ZA