Comparative study of aligned and nonaligned poly(ε-caprolactone) ï¬brous scaffolds prepared by solution blow spinning
J. biomed. mater. res. B appl. biomater
; 107(5): 1462-1470, Jul. 2019. ilus, graf
Article
em En
| SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-1022560
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
Fibrous scaffolds have become popular in tissue engineering (TE) due to their morphological resemblance to extracellular matrix components. While electrospinning is the most common technique in the ï¬eld, solution blow spinning is an emerging technique with great potential. One of its many advantages is that it can produce aligned ï¬bers with a very simple experimental setup. This work aimed to fabricate poly (ε-caprolactone) mats with aligned ï¬bers and compare them to nonaligned ones. For that, samples were produced using three rotational speeds of a cylindrical collector and characterized in terms of ï¬ber alignment and diameter, mechanical properties, wettability, and biological response. Results showed that with a static collector, ï¬bers were randomly deposited and nonaligned. As the speed was increased, the ï¬bers began to align (as proven by image analysis), resulting in a change in mechanical behavior, but no differences in ï¬ber diameter. Cells cultured on aligned samples were more elongated, and a higher alignment degree seemed to favor cellular growth. The results conï¬rmed the potential of this up-and-coming technique to produce aligned ï¬bers for TE. (AU)
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Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-IDPCPROD
Assunto principal:
Materiais Biocompatíveis
/
Engenharia Tecidual
Limite:
Humans
Idioma:
En
Revista:
J. biomed. mater. res. B appl. biomater
Ano de publicação:
2019
Tipo de documento:
Article