Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes
Biol. Res
; 51: 38, 2018. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1038781
Biblioteca responsável:
CL1.1
ABSTRACT
BACKGROUND:
Hydrogen sulfide has been shown to improve the quality of oocytes destined for in vitro fertilization. Although hydrogen sulfide is capable of modulating ion channel activity in somatic cells, the role of hydrogen sulfide in gametes and embryos remains unknown. Our observations confirmed the hypothesis that the KATP and L-type Ca2+ ion channels play roles in porcine oocyte ageing and revealed a plausible contribution of hydrogen sulfide to the modulation of ion channel activity.RESULTS:
We confirmed the benefits of the activation and suppression of the KATP and L-type Ca2+ ion channels, respectively, for the preservation of oocyte quality.CONCLUSIONS:
Our experiments identified hydrogen sulfide as promoting the desired ion channel activity, with the capacity to protect porcine oocytes against cell death. Further experiments are needed to determine the exact mechanism of hydrogen sulfide in gametes and embryos.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Oócitos
/
Canais de Cálcio
/
Senescência Celular
/
Canais de Potássio Cálcio-Ativados
/
Sulfeto de Hidrogênio
Limite:
Animais
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
República Tcheca
Instituição/País de afiliação:
Charles University/CZ
/
Institute of Animal Science/CZ