Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis
Braz. j. infect. dis
; 21(2): 176-179, Mar.-Apr. 2017. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1039188
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. Methods:
Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay.Results:
BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors.Conclusion:
BDNF may be released in the context of the active TR inflammatory response.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doenças Negligenciadas
/
Zoonoses
Base de dados:
LILACS
Assunto principal:
Biomarcadores
/
Toxoplasmose Ocular
/
Coriorretinite
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Estados Unidos
Instituição/País de afiliação:
Centro Brasileiro de Ciências Visuais/BR
/
Massachusetts Eye and Ear Infirmary/US
/
Universidade Federal de Minas Gerais/BR
/
Universidade do Extremo Sul Catarinense/BR