HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C
Rev. Soc. Bras. Med. Trop
; 52: e20170427, 2019. tab
Artigo
em Inglês
| LILACS
| ID: biblio-1041583
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC.METHODS:
PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients.RESULTS:
There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree.CONCLUSIONS:
The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Antígenos de Plaquetas Humanas
/
Carcinoma Hepatocelular
/
Hepatite C Crônica
/
Neoplasias Hepáticas
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual Paulista/BR
