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Insulin signaling in the whole spectrum of GH deficiency
Garmes, Heraldo Mendes; Castillo, Alejandro Rosell.
Afiliação
  • Garmes, Heraldo Mendes; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Clínica Médica. Campinas. BR
  • Castillo, Alejandro Rosell; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Clínica Médica. Campinas. BR
Arch. endocrinol. metab. (Online) ; 63(6): 582-591, Nov.-Dec. 2019. tab
Article em En | LILACS | ID: biblio-1055018
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT GH is one of the insulin counterregulatory hormones which acts in the opposite way to insulin, increasing the glucose production by the liver and kidneys and decreasing glucose uptake from peripheral tissues, thus being a hyperglycemic hormone. When in excess, as in acromegaly, it induces glucose intolerance and diabetes. As expected, patients with GH deficiency (GHD) have hypoglycemia, especially in early childhood, but as GH is also a lipolytic hormone, these patients are becoming obese with higher percentages of body fat. Although obesity in general is directly related to insulin resistance, in patients with GH secretion disorders this relationship may be altered. In acromegaly there is a decrease in fat mass with worsening insulin sensitivity and mice with isolated GHD are characterized by greater insulin sensitivity despite excess fat mass. In humans with GHD, body composition shows increased body fat and decreased free fat mass, but the results regarding insulin sensitivity are still controversial in these patients. These discrepant results regarding insulin sensitivity in patients with GHD suggest the existence of other variables influencing these results. In the present review, we will try to follow the path of the different researches conducted on this subject, both in animal and human models, with the goal of understanding the current knowledge of insulin sensitivity across the spectrum of GHD. Arch Endocrinol Metab. 2019;63(6)582-91
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Resistência à Insulina / Transdução de Sinais / Hormônio do Crescimento Humano / Glucose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Resistência à Insulina / Transdução de Sinais / Hormônio do Crescimento Humano / Glucose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Arch. endocrinol. metab. (Online) Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil