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Expression profile of salivary micro RNA-21 and 31 in oral potentially malignant disorders
Uma Maheswari, Thirupambaram Natarajasundaram; Nivedhitha, Malli Sureshbabu; Ramani, Prathiba.
Afiliação
  • Uma Maheswari, Thirupambaram Natarajasundaram; Saveetha University. Saveetha Dental College. Department of Oral Medicine and Radiology,. Chennai. IN
  • Nivedhitha, Malli Sureshbabu; Saveetha University. Saveetha Dental College. Department of Conservative Dentistry and Endodontics. Chennai. IN
  • Ramani, Prathiba; Saveetha University. Saveetha Dental College. Department of Oral and Maxillofacial Pathology. Chennai. IN
Braz. oral res. (Online) ; 34: e002, 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1055528
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Oral potentially malignant disorders (OPMD) possess significant chances of malignancy conversion. In order to develop an early diagnostic tool, the present study evaluated the expression of miRNA-21 and 31 as salivary markers. The case-control study was carried out in 36 healthy participants as controls and in 36 patients who were newly diagnosed as OPMD having four different lesions including leucoplakia, oral sub mucous fibrosis (OSMF)궱, oral lichen planus, and (OSMF)궱 with leucoplakia. The samples were also classified as non-dysplastic, or with mild, moderate, and severe dysplasia according to their histopathological reports. The salivary miRNA-21 and 31 expressions were studied using real-time PCR. The statistical analysis was carried out using SPSS version 22. Salivary miRNA-21 (p-value = 0.02) and 31 (p-value = 0.01) were significantly upregulated in severe dysplasia compared with control. Among the different lesions, leucoplakia had significant upregulation of miRNA-21 and 31. miRNA-21 can be used as a diagnostic marker with specificity of 66% and sensitivity of 69%. The area under the ROC curve was 0.820 for miRNA-21 and 0.5 for miRNA-31, which proved that miRNA-21 is a better diagnostic marker than miRNA-31 for OPMD.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Lesões Pré-Cancerosas / Saliva / Neoplasias Bucais / MicroRNAs Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Braz. oral res. (Online) Assunto da revista: Odontologia Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Saveetha University/IN

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Lesões Pré-Cancerosas / Saliva / Neoplasias Bucais / MicroRNAs Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Braz. oral res. (Online) Assunto da revista: Odontologia Ano de publicação: 2020 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Saveetha University/IN
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