Randomized trial of physiotherapy and hypertonic saline techniques for sputum induction in asthmatic children and adolescents
Clinics
; 75: e1512, 2020. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1055871
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVES:
This study aimed to analyze the efficiency of physiotherapy techniques in sputum induction and in the evaluation of pulmonary inflammation in asthmatic children and adolescents. Although hypertonic saline (HS) is widely used for sputum induction (SI), specific techniques and maneuvers of physiotherapy (P) may facilitate the collection of mucus in some asthmatic children and adolescents.METHODS:
A randomized crossover study was performed in patients with well-controlled asthma, and 90 sputum samples were collected. Children and adolescents were assessed using spirometry and randomized at entry into one of three sputum induction techniques (i) 3% hypertonic saline - HS technique; (ii) physiotherapy (oscillatory positive expiratory pressure, forced expiration, and acceleration of expiratory flow) - P technique; and (iii) hypertonic saline + physiotherapy - HSP technique. ClinicalTrials.gov NCT03136042.RESULTS:
The total cells (mL) and the percentage (%) of differential inflammatory cells were similar in all techniques. The sputum weight (g) in the HSP technique was significantly higher than that in the HS technique. In all techniques, the percentage of viable cells was >50%, and there was no difference between the HS and P techniques. Moreover, sputum induction did not cause any alterations in the pulmonary function of patients.CONCLUSION:
The physiotherapy sputum collection technique was effective in obtaining viable cells from mucus samples and yielded the same amount of sputum as the gold standard technique (hypertonic saline). In addition, the physiotherapy maneuvers were both safe and useful for sputum induction in asthmatic children and adolescents with well-controlled asthma.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Asma
/
Solução Salina Hipertônica
/
Escarro
/
Modalidades de Fisioterapia
Tipo de estudo:
Ensaio clínico controlado
Limite:
Adolescente
/
Criança
/
Humanos
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Hospital do Servidor Publico do Estado de Sao Paulo (IAMSPE)/BR
/
Universidade Cidade de Sao Paulo (UNICID)/BR
/
Universidade de Sao Paulo/BR