Age-dependent acquisition of protective immunity to malaria in riverine populations of the Amazon Basin of Brazil
American Journal Tropical Medicine and Hygiene
; 80(3): 452-459, 2009 mar. tab, graf
Article
em En
| SES-SP, SESSP-SUCENPROD, SES-SP
| ID: biblio-1059614
Biblioteca responsável:
BR93.2
Localização: BR93.2
ABSTRACT
Five community-based cross-sectional surveys of malaria morbidity and associated risk factors in remote riverine populations in northwestern Brazil showed average parasite rates of 4.2% (thick-smear microscopy) and 14.4% (polymerase chain reaction [PCR]) in the overall population, with a spleen rate of 13.9% among children 2-9 years of age. Plasmodium vivax was 2.8 times more prevalent than P. falciparum, with rare instances of P. malariae and mixed-species infections confirmed by PCR; 9.6% of asymptomatic subjects had parasitemias detected by PCR. Low-grade parasitemia detected by PCR only was a risk factor for anemia, after controlling for age and other covariates. Although clinical and subclinical infections occurred in all age groups, the risk of infection and disease decreased significantly with increasing age, after adjustment for several covariates in multilevel logistic regression models. These findings suggest that the continuous exposure to hypo- or mesoendemic malaria may induce significant anti-parasite and anti-disease immunity in native Amazonians...
Texto completo:
1
Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-SUCENPROD
Assunto principal:
Malária
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
American Journal Tropical Medicine and Hygiene
Ano de publicação:
2009
Tipo de documento:
Article