Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of RiskBut Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease
Journal of the American Heart Association
; 5(6): 2-16, 2016. tab, graf
Article
em En
| SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-1064402
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
Background-We evaluated lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in patients with stable coronary heart disease before and during treatment with darapladib, a selective Lp-PLA2 inhibitor, in relation to outcomes and the effects ofdarapladib in the STABILITY trial. Methods and Results-Plasma Lp-PLA2 activity was determined at baseline (n=14 500); at 1 month (n=13 709); serially (n=100)at 3, 6, and 18 months; and at the end of treatment. Adjusted Cox regression models evaluated associations between Lp-PLA2activity levels and outcomes. At baseline, the median Lp-PLA2 level was 172.4 lmol/min per liter (interquartile range 143.1204.2lmol/min per liter). Comparing the highest and lowest Lp-PLA2 quartile groups, the hazard ratios were 1.50 (95% CI 1.231.82) forthe primary composite end point (cardiovascular death, myocardial infarction, or stroke), 1.95 (95% CI 1.292.93) forhospitalization for heart failure, 1.42 (1.071.89) for cardiovascular death, and 1.37 (1.031.81) for myocardial infarction afteradjustment for baseline characteristics, standard laboratory variables, and other prognostic biomarkers. Treatment with darapladibled to a 65% persistent reduction in median Lp-PLA2 activity. There were no associations between on-treatment Lp-PLA2 activityor changes of Lp-PLA2 activity and outcomes, and there were no significant interactions between baseline and on-treatment LpPLA2 activity or changes in Lp-PLA2 activity levels and the effects of darapladib on outcomes...
Texto completo:
1
Coleções:
06-national
/
BR
Base de dados:
SES-SP
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SESSP-IDPCPROD
Assunto principal:
Doenças das Artérias Carótidas
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Colecistite
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Lipase Lipoproteica
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Infarto do Miocárdio
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
Journal of the American Heart Association
Ano de publicação:
2016
Tipo de documento:
Article