Effects of soy germ isoflavones and hormone therapy on nitric oxide derivatives, low-density lipoprotein oxidation, and vascular reactivity in hypercholesterolemic postmenopausal women
Menopause
; 13(6): 942-950, 2006 03 20.
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1064733
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
Objective:
To evaluate the effects of soy germ isoflavones and hormone therapy on vascular reactivity, the formation of nitric oxide derivatives, and lipid peroxidation in hypercholesterolemic postmenopausal women.Design:
Women were treated with soy germ, 17A-estradiol or 17A-estradiol + noretisterone acetate for 3 months after taking placebo for 1 month. The plasma concentrations of nitrite + nitrate and S-nitrosothiols were evaluated by gaseous phase chemiluminescence; nitrotyrosine, electronegative low-density lipoprotein, and estradiol levels were determined by enzymelinked immunosorbent assay; cholesterol oxides and isoflavones were determined by gas chromatography and high-performance liquid chromatography, respectively. Vascular reactivity was analyzed by high-resolution ultrasonography.Results:
Soy germ isoflavones and hormone therapy induced a decrease in nitrite + nitrate, electronegative low-density lipoprotein, and cholesterol oxides, as well as an increase in S-nitrosothiols. Soy germ isoflavones lowered electronegative low-density lipoprotein, and cholesterol oxides more efficiently than did hormone therapy. Only soy isoflavones inhibited nitrotyrosine formation. A significant improvement of vascular reactivity was only seen in women treated with 17A-estradiol.Conclusions:
The soy germ isoflavones and 17A-estradiol, alone or associated with noretisterone acetate, in the doses and forms used here, have similar effects on the bioavailability of nitric oxide. Soy germ treatment inhibited lipid peroxidation more effectively than hormone therapy.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Glycine max
/
Doenças Vasculares
/
Colesterol Oxidase
/
Isoflavonas
/
LDL-Colesterol
Tipo de estudo:
Ensaio clínico controlado
Limite:
Idoso
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Menopause
Ano de publicação:
2006
Tipo de documento:
Artigo
Instituição/País de afiliação:
1Dante Pazzanese Institute of Cardiology/BR
/
1School of Pharmaceutical Sciences/BR
/
Dante Pazzanese Institute of Cardiology/BR
/
InCor Heart Institute School of Medicine/BR
/
School of Pharmaceutical Sciences/BR