Crotoxin Novel activities for a classic â-neurotoxin
Toxicon
; 55(6): 1045-1060, Jan 28, 2010.
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IBPROD, Sec. Est. Saúde SP, SESSP-IBACERVO
| ID: biblio-1068250
Biblioteca responsável:
BR78.1
Localização: BR78.1
ABSTRACT
Crotoxin, the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, was the first snake venom protein to be purified and crystallized. Crotoxin is a heterodimericb-neurotoxin that consists of a weakly toxic basic phospholipase A2 and a nonenzymatic, non-toxic acidic component (crotapotin). The classic biological activities normally attributed to crotoxin include neurotoxicity, myotoxicity, nephrotoxicity andcardiotoxicity. However, numerous studies in recent years have shown that crotoxin also has immunomodulatory, anti-inflammatory, anti-microbial, anti-tumor and analgesic actions. In this review, we describe the historical background to the discovery of crotoxinand its main toxic activities and then discuss recent structurefunction studies and investigations that have led to the identification of novel pharmacological activities for the toxin.
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Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IBACERVO
/
SESSP-IBPROD
Assunto principal:
Venenos de Serpentes
/
Crotalus cascavella
/
Crotoxina
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Toxicon
Ano de publicação:
2010
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Butantan/BR