Randomized Trial of Machine Perfusion Versus Cold Storage in Recipients of Deceased Donor Kidney Transplants With High Incidence of Delayed Graft Function
Transplant Direct
; 3(5): .155-.155, 2017.
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1068304
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
BACKGROUND:
This study compared the use of static cold storage versus continuous hypothermic machine perfusion in a cohort of kidney transplant recipients at high risk for delayed graft function (DGF).METHODS:
In this national, multicenter, and controlled trial, 80 pairs of kidneys recovered from brain-dead deceased donors were randomized to cold storage or machine perfusion, transplanted, and followed up for 12 months. The primary endpoint was the incidence of DGF. Secondary endpoints included the duration of DGF, hospital stay, primary nonfunction, estimated glomerular filtration rate, acute rejection, and allograft and patient survivals.RESULTS:
Mean cold ischemia time was high but not different between the 2 groups (25.6 ± 6.6 hours vs 25.05 ± 6.3 hours, 0.937). The incidence of DGF was lower in the machine perfusion compared with cold storage group (61% vs. 45%, P = 0.031). Machine perfusion was independently associated with a reduced risk of DGF (odds ratio, 0.49; 95% confidence interval, 0.26-0.95). Mean estimated glomerular filtration rate tended to be higher at day 28 (40.6 ± 19.9 mL/min per 1.73 m2 vs 49.0 ± 26.9 mL/min per 1.73 m2; P = 0.262) and 1 year (48.3 ± 19.8 mL/min per 1.73 m2 vs 54.4 ± 28.6 mL/min per 1.73 m2; P = 0.201) in the machine perfusion group. No differences in the incidence of acute rejection, primary nonfunction (0% vs 2.5%), graft loss (7.5% vs 10%), or death (8.8% vs 6.3%) were observed...
Buscar no Google
Coleções:
Bases de dados nacionais
/
Brasil
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Neoplasias do Rim, Pelve Renal e Ureteral
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Perfusão
/
Transplante de Rim
Tipo de estudo:
Ensaio clínico controlado
/
Estudo de incidência
/
Fatores de risco
Idioma:
Inglês
Revista:
Transplant Direct
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Department of Internal Medicine-UNESP/BR
/
Hospital Alemão Oswaldo Cruz/BR
/
Hospital Beneficência Portuguesa/BR
/
Hospital Santa Marcelina/BR
/
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo/BR
/
Hospital de Base de São José do Rio Preto/BR
/
Hospital do Rim/BR
/
Hospital do Rim, Universidade Federal de São Paulo/BR
/
Hospital do Servidor Público Estadual/BR
/
Instituto Dante Pazzanese de Cardiologia/BR