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In vitro reactivity and growth inhibition of EPEC serotype O111 and STEC serotypes O111 and O157 by homologous and heterologous chicken egg yolk antibody
Amaral, José Araujo; De Franco, Milene Tino; Quintanilla, Lucy Zapata; Carbonare, Solange Barros.
Afiliação
  • Amaral, José Araujo; Instituto Butantan. São Paulo. BR
  • De Franco, Milene Tino; Instituto Butantan. São Paulo. BR
  • Quintanilla, Lucy Zapata; Instituto Butantan. São Paulo. BR
  • Carbonare, Solange Barros; Instituto Butantan. São Paulo. BR
Veterinary Research Communications ; 32(4): 281-290, 2008.
Article em En | SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO | ID: biblio-1068400
Biblioteca responsável: BR78.1
Localização: BR78.1
ABSTRACT
IgY is a chicken egg yolk antibody which has been used for treatment and prophylaxis of gastrointestinal infections. Our aim was to verify if IgY obtained from chickens immunized with EPEC O111, STEC O111 and STEC O157 is able to show in vitro reactivity and biological activity towards the three bacteria. IgY was obtained from eggs laid before and after immunization with each bacterium. The preparations of IgY anti-EPEC O111 and anti-STEC O111 shared high reactivity detected by ELISA and growth inhibition ability towards both bacteria EPEC O111 and STEC O111. Nevertheless, the preparation of IgY anti-STEC O157 showed high reactivity and growth inhibitory effect only towards the homologous strain. Our results showing in vitro biological activity of IgY reinforce its use as an alternative for the treatment or prophylaxis of E. coli infections and encourage the development of in vivo studies for a possible future human therapeutic use
Assuntos
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Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IBACERVO / SESSP-IBPROD Assunto principal: Imunoglobulinas / Galinhas / Escherichia coli Enteropatogênica Limite: Animals Idioma: En Revista: Veterinary Research Communications Ano de publicação: 2008 Tipo de documento: Article
Buscar no Google
Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IBACERVO / SESSP-IBPROD Assunto principal: Imunoglobulinas / Galinhas / Escherichia coli Enteropatogênica Limite: Animals Idioma: En Revista: Veterinary Research Communications Ano de publicação: 2008 Tipo de documento: Article