ESCMID-EUCIC clinical guidelines on decolonization of multidrug-resistant Gram-negative bacteria carriers
Clin. microbiol. infect
; 25(7): [1-11], Jan. 29, 2019.
Article
em En
| BIGG
| ID: biblio-1094956
Biblioteca responsável:
BR1.1
ABSTRACT
The aim of these guidelines is to provide recommendations for decolonizing regimens targeting multidrug-resistant Gram-negative bacteria (MDR-GNB) carriers in all settings. Methods:
These evidence-based guidelines were produced after a systematic review of published studies on decolonization interventions targeting the following MDR-GNB third-generation cephalosporinresistant Enterobacteriaceae (3GCephRE), carbapenem-resistant Enterobacteriaceae (CRE), aminoglycoside-resistant Enterobacteriaceae (AGRE), fluoroquinolone-resistant Enterobacteriaceae (FQRE), extremely drug-resistant Pseudomonas aeruginosa (XDRPA), carbapenem-resistant Acinetobacter baumannii (CRAB), cotrimoxazole-resistant Stenotrophomonas maltophilia (CRSM), colistin-resistant Gram-negative organisms (CoRGNB), and pan-drug-resistant Gram-negative organisms (PDRGNB). The recommendations are grouped by MDR-GNB species. Faecal microbiota transplantation has been discussed separately. Four types of outcomes were evaluated for each target MDR-GNB(a) microbiological outcomes (carriage and eradication rates) at treatment end and at specific post-treatment time-points; (b) clinical outcomes (attributable and all-cause mortality and infection incidence) at the same timepoints and length of hospital stay; (c) epidemiological outcomes (acquisition incidence, transmission and outbreaks); and (d) adverse events of decolonization (including resistance development). The level of evidence for and strength of each recommendation were defined according to the GRADE approach. Consensus of a multidisciplinary expert panel was reached through a nominal-group technique for the final list of recommendations.
Texto completo:
1
Coleções:
05-specialized
Base de dados:
BIGG
Assunto principal:
Cefalosporinas
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Infecções por Bactérias Gram-Negativas
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Fluoroquinolonas
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Infecções por Enterobacteriaceae
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Aminoglicosídeos
Tipo de estudo:
Guideline
Idioma:
En
Revista:
Clin. microbiol. infect
Ano de publicação:
2019
Tipo de documento:
Article