High frequency of chlamydia pneumoniae and risk factors in children with acute respiratory infection
Braz. j. microbiol
; 51(2): 629-636, Jun., 2020. graf., tab.
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1100142
Biblioteca responsável:
BR79.1
ABSTRACT
This study was performed as a contribution for a better understanding of Chlamydia pneumoniae frequency in children with respiratory infections. A total of 416 children were recruited from two clinical centers in Sao Luis, Brazil. Of these patients, 165 children had upper respiratory tract infections (URTI), 150 had community-acquired pneumonia (CAP), and 101 were asymptomatic volunteer children. Clinical and epidemiological data from the participants were recorded. Nasopharyngeal swab samples were collected to extract DNA. C. pneumoniae DNA positivity and copy numbers were obtained by an absolute quantitative real-time PCR method. RESULTS:
Positivity for C. pneumoniae DNA was higher in samples from URTI children (38.2%) and from CAP children (18.0%) than in those from the control group (7.9%; p < 0.001). Moreover, C. pneumoniae DNA was denser in children with URTI than in asymptomatic children. Considering the cutoff, the highest value of C. pneumoniae DNA found in asymptomatic children of the 3.98 log10 copies/mL, 8.5% (14/165) of the children with URTI, and 3.3% (5/150) with CAP presented high copy numbers of C. pneumoniae DNA.CONCLUSION:
Taken together, these results revealed a high frequency of C. pneumoniae in both children with URTI and CAP.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Infecções Respiratórias
/
Chlamydophila pneumoniae
Tipo de estudo:
Estudo de etiologia
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. microbiol
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Institute Dante Pazzanese of Cardiology/BR
/
Universidade CEUMA/BR
/
University of Sao Paulo/BR
/
University of Washington/US