Superinfection exclusion studies using West Nile virus and Culex flavivirus strains from Argentina
Mem. Inst. Oswaldo Cruz
; 115: e200012, 2020. tab, graf
Artigo
em Inglês
| LILACS, Sec. Est. Saúde SP
| ID: biblio-1135267
Biblioteca responsável:
BR1.1
ABSTRACT
In Argentina, many Flavivirus were recognised including West Nile virus (WNV). During 2009 several strains of Culex Flavivirus (CxFV), an insect-specific flavivirus, were isolated in the same region where circulation of WNV was detected. Hence, the objective of this study was to analyse the effect of co-infection in vitro assays using CxFV and WNV Argentinean strains in order to evaluate if CxFV could affect WNV replication. Our results showed that WNV replication was suppressed when multiplicity of infection (MOI) for CxFV was 10 or 100 times higher than WNV. Nevertheless, in vivo assays are necessary in order to evaluate the superinfection exclusion potential.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Dengue
Base de dados:
LILACS
/
Sec. Est. Saúde SP
Assunto principal:
Vírus do Nilo Ocidental
/
Superinfecção
/
Culex
/
Flavivirus
/
Insetos Vetores
Limite:
Animais
País/Região como assunto:
América do Sul
/
Argentina
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Instituto Nacional de Enfermedades Virales Humanas Dr Julio I Maiztegui/AR
/
Århus University/DK
