Impact of preoperative aspirin on long-term outcomes in diabetic patients following coronary artery bypass grafting: a propensity score matched study
Rev. bras. cir. cardiovasc
; 35(6): 859-868, Nov.-Dec. 2020. tab, graf
Artigo
em Inglês
| LILACS, Sec. Est. Saúde SP
| ID: biblio-1144000
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Introduction:
This study aimed to determine the effect of preoperative aspirin administration on early and long-term clinical outcomes in patients suffering from diabetes mellitus (DM) undergoing coronary artery bypass grafting (CABG).Methods:
In this observational study, a total of 315 patients were included and grouped according to the time interval between their last aspirin dose and the time of surgery; patients who had been continued aspirin intake with last administered dose ≤ 24-hours before CABG (n=144) and those who had been given the last dose of aspirin between 24 to 48 hours before CABG (n=171).Results:
Multivariable analysis showed that the continuation of preoperative aspirin intake ≤ 24 hours before CABG in patients with DM is associated with reduced incidence of 30-day major adverse cardiac and cerebral events (MACCE) (P=0.004) as well as reduced incidence of composite 30-day mortality/MACCE (P=0.012). During mean follow-up of 37±17.5 months, the unadjusted hazard ratio (HR) showed that aspirin ≤ 24 hours prior CABG in patients with DM significantly reduced the incidence of MACCE and composite of mortality/MACCE during follow-up (HR 0.50; 95% confidence interval [CI] 0.29-0.87; P=0.014 and HR 0.61; 95% CI 0.38-0.97; P=0.039, respectively). However, after propensity score (PS) matching, the PS-adjusted HR showed a non-significant trend towards the reduction of MACCE during follow-up (HR 0.58; 95% CI 0.31-1.06; P=0.081).Conclusion:
Continuation of preoperative aspirin intake ≤ 24 hours before CABG in patients with DM is associated with reduced incidence of early MACCE, but without significant influence on long-term outcomes.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Diabetes Mellitus
/
Doenças do Sistema Endócrino
Base de dados:
LILACS
/
Sec. Est. Saúde SP
Assunto principal:
Anti-Inflamatórios não Esteroides
/
Aspirina
/
Ponte de Artéria Coronária
/
Diabetes Mellitus
/
Intervenção Coronária Percutânea
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. cir. cardiovasc
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Medinet Heart Center Ltd/PL
/
Nottingham University Hospital/GB
/
Nowa Sol Multidisciplinary Hospital/PL
/
Sana-Heart Center Cottbus/DE
/
Universidade de Pernambuco/BR