Positive fluid balance as an early biomarker for acute kidney injury: a prospective study in critically ill adult patients
Clinics
; 76: e1924, 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1153960
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVES:
Positive fluid balance is frequent in critically ill patients and has been considered a potential biomarker for acute kidney injury (AKI). This study aimed to evaluate positive fluid balance as a biomarker for the early detection of AKI in critically ill patients.METHODS:
This was a prospective cohort study. The sample was composed of patients ≥18 years old who stayed ≥3 days in an intensive care unit. Fluid balance, urinary output and serum creatinine were assessed daily. AKI was diagnosed by the Kidney Disease Improving Global Outcome criteria.RESULTS:
The final cohort was composed of 233 patients. AKI occurred in 92 patients (40%) after a median of 3 (2-6) days following ICU admission. When fluid balance was assessed as a continuous variable, a 100-ml increase in fluid balance was independently associated with a 4% increase in the odds of AKI (OR 1.04; 95% CI 1.01-1.08). Positive fluid balance categorized using different thresholds was always significantly associated with subsequent detection of AKI. The mixed effects model showed that increased fluid balance preceded AKI by 4 to 6 days.CONCLUSION:
These results suggest that a positive fluid balance might be an early biomarker for AKI development in critically ill patients.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doenças do Sistema Endócrino
/
Neoplasias do Rim, Pelve Renal e Ureteral
Base de dados:
LILACS
Assunto principal:
Estado Terminal
/
Injúria Renal Aguda
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Departamento de Epidemiologia, Faculdade de Saude Publica, Universidade de Sao Paulo/BR
/
Escola Bahiana de Medicina e Saude Publica/BR
/
LIM 12, Disciplina de Nefrologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo/BR
/
Medicina Interna e Apoio Diagnostico, Universidade Federal da Bahia/BR
/
Monte Tabor Hospital Sao Rafael/BR
/
Universidade do Estado da Bahia/BR