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Semen quality from patients affected by seminomatous and non-seminomatous testicular tumor
Xavier, Rosana; Carvalho, Renata Cristina de; Fraietta, Renato.
Afiliação
  • Xavier, Rosana; Universidade Federal de São Paulo. Divisão de Urologia. Departamento de Cirurgia. São Paulo. BR
  • Carvalho, Renata Cristina de; Universidade Federal de São Paulo. Divisão de Urologia. Departamento de Cirurgia. São Paulo. BR
  • Fraietta, Renato; Universidade Federal de São Paulo. Divisão de Urologia. Departamento de Cirurgia. São Paulo. BR
Int. braz. j. urol ; 47(3): 495-502, May-June 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1154505
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT Testicular cancer is considered a rare disease affecting approximately 1% to 2% of the male population. This neoplasm has a cure rate of over 95%; as a result, a major concern is the future of fertility of carriers from this disease. There are several histological subtypes of testicular tumors; however, the Testicular Germ Cell Tumors (TGCTs), comprising both seminoma and non-seminoma tumors, are considered the main subtypes of testicular neoplasms. TGCT are characterized by being a solid tumor that mostly affects young men aged between 15 and 40 years old. While TGCT subtypes may have an invasive potential, seminoma subtype does not affect other cells rather than germ cells, while non-seminomas have more invasive properties and can achieve somatic cells; thus, having a more aggressive nature. This research intends to review the literature regarding information about sperm parameters, correlating the data found in those studies to the subfertility and infertility of patients with TCGTs. Furthermore, it will also correlate the data to the non-seminoma and seminoma histological subtypes from pre- and post-cancer therapy. PubMed databases were used. Searched keywords included seminoma AND non-seminoma; male infertility; germ cell tumor; chemotherapy AND radiotherapy. Only articles published in English were considered. Current studies demonstrate that both TGCT subtypes promote deleterious effects on semen quality resulting in decreased sperm concentration, declined sperm total motility and an increase in the morphology alterations. However, findings suggest that the non-seminoma subtype effects are more pronounced and deleterious. More studies will be necessary to clarify the behavior of seminoma and non-seminoma tumors implicating the reproductive health of male patients.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Neoplasias Testiculares / Seminoma / Neoplasias Embrionárias de Células Germinativas Tipo de estudo: Pesquisa qualitativa Limite: Adolescente / Adulto / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal de São Paulo/BR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Neoplasias Testiculares / Seminoma / Neoplasias Embrionárias de Células Germinativas Tipo de estudo: Pesquisa qualitativa Limite: Adolescente / Adulto / Humanos / Masculino Idioma: Inglês Revista: Int. braz. j. urol Assunto da revista: Urologia Ano de publicação: 2021 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal de São Paulo/BR
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