Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019
Rev. Soc. Bras. Med. Trop
; 54: e0728-2020, 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1155535
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.METHODS:
MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.RESULTS:
Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V).CONCLUSIONS:
The proportion of mono-SM-resistant TB among new patients was higher.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doenças Negligenciadas
/
Tuberculose
Base de dados:
LILACS
Assunto principal:
Preparações Farmacêuticas
/
Tuberculose Resistente a Múltiplos Medicamentos
/
Mycobacterium tuberculosis
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Hangzhou Center for Disease Control and Prevention/CN
/
Zhejiang University/CN
