Population survey to determine risk factors for Mycobacterium leprae transmission and infection
In. Bakker, Mirjam. Epidemiology and prevention of leprosy: a cohort study in Indonesia. s.l, The Netherlands Leprosy Relief, 2005. p.72-86, map, tab.
Monography
em En
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1247181
Biblioteca responsável:
BR191.1
Localização: [{"text": "BR191.1", "_a": "WC335.300", "_b": "B179e"}]
ABSTRACT
Background:
Not every leprosy patient is equally effective in transmitting Mycobacterium leprae. We studied the spatial distribution of infection (using seropositivity as a marker) in the population to identifity which disease characteristics of leprosy patients are important in transmission.Methods:
Clinical data and blood samples for anti-M.leprae ELISA were collected during a cross-sectional survey on five Indonesian islands highly endemic for leprosy. A geographic information system (GIS) was used to define contacts of patients. We investigated spatial clustering of patients and seropositive people and used logist regression to determine risk factors for seropositivity.Results:
Of the 3986 people examined for leprosy, 3271 gave blood. Seroprevalence varied between islands (1.7-8.7%) and correlated significantly with leprosy prevalence. Five clusters of patients and two clusters of seropositives were detected. In multivariate analysis, seropositivity significantly differed to be the best discriminator of contact groups with higher seroprevalence contacts of seropositive patients had an adjusted odds ratio (aOR) of 1.75 (95% CI 0.92-3,31). This increased seroprevalence was strongest for contact groups living _< 75 metres of two seropositive patients (aOR3.07;95%CI1.74-5.42).Conclusions:
In this highly endemic area for leprosy, not only household contacts of seropositive patients, but also persons living in the vicinity of seropositive patient were more likely to harbour antibodies against M.leprae. Through measuring the serological status of patients and using a broader definition of contacts, higher risk groups can be more specifically identified
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Coleções:
06-national
/
BR
Base de dados:
HANSEN
/
HANSENIASE
/
SES-SP
/
SESSP-ILSLACERVO
Assunto principal:
Ensaio de Imunoadsorção Enzimática
/
Modelos Logísticos
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Hanseníase
/
Mycobacterium leprae
Tipo de estudo:
Etiology_studies
/
Evaluation_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Monography