Perspectives of bilateral thoracic sympathectomy for treatment of heart failure
Clinics
; 76: e3248, 2021. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1286075
Biblioteca responsável:
BR1.1
ABSTRACT
Surgical neuromodulation therapies are still considered a last resort when standard therapies have failed for patients with progressive heart failure (HF). Although a number of experimental studies have provided robust evidence of its effectiveness, the lack of strong clinical evidence discourages practitioners. Thoracic unilateral sympathectomy has been extensively studied and has failed to show significant clinical improvement in HF patients. Most recently, bilateral sympathectomy effect was associated with a high degree of success in HF models, opening the perspective to be investigated in randomized controlled clinical trials. In addition, a series of clinical trials showed that bilateral sympathectomy was associated with a decreased risk of sudden death, which is an important outcome in patients with HF. These aspects indicates that bilateral sympathectomy could be an important alternative in the treatment of HF wherein pharmacological treatment barely reaches the target dose.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doença Cardiovascular
/
Outras Doenças Circulatórias
/
Doenças da Pele
Base de dados:
LILACS
Assunto principal:
Procedimentos Cirúrgicos Torácicos
/
Insuficiência Cardíaca
/
Hiperidrose
Tipo de estudo:
Ensaio clínico controlado
Limite:
Humanos
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Suécia
Instituição/País de afiliação:
Karolinska Institutet/SE
/
Universidade de Sao Paulo/BR