Intoxicaciones por bupropión: presentación de caso / Bupropion toxicity: a risk to consider

RESUMEN

Resumen En Colombia las intoxicaciones autoinfligidas vienen en aumento en los últimos años, la principal causa son los medicamentos y dentro de éstos, los psicofármacos. El bupropión es un antidepresivo, inhibidor débil de la recaptación de dopamina y noradrenalina; está aprobado para el tratamiento del trastorno depresivo mayor y se ha utilizado en otras indicaciones como depresión bipolar, abandono del cigarrillo, trastorno por déficit de atención e hiperactividad (TDAH), obesidad y disfunción sexual. Sus principales efectos adversos son cardiovasculares y neurológicos. Esta serie de casos busca evidenciar las complicaciones asociadas a su toxicidad y resaltar algunos aspectos en el manejo de estas intoxicaciones; tales como el uso de la irrigación gastrointestinal y el uso de emulsiones lipídicas. MÉD. UIS. 2020;33(2)117-121.

ABSTRACT

Abstract In Colombia, self-inflicted drug poisonings have been increasing in recent years, and within these, psychotropic drugs. The vast majority of psychoactive drug poisonings are explained by SSRI tricyclic antidepressants and anticonvulsants. Bupropion is an antidepressant, dopamine and norepinephrine reuptake inhibitor; approved for the treatment of major depressive disorder and used in other indications such as bipolar depression, smoking cessation, attention deficit disorder the importance of this series of cases is to sensitize health personnel about the increase in prescription and therefore more Toxicity risks associated with this medicine. There is little literature on the management of bupropion toxicity, understanding these and it is important to highlight its amphetamine-like structure that explains neurological risks such as seizures and cardiovascular events as arrhythmias, although it is true that there is no consensus on the management, it is worth highlighting the usefulness of lipid emulsions This series of cases, being the first in Colombia, seeks to highlight the complications associated with its toxicity and highlight some aspects in the management of this poisoning; such as the use of gastrointestinal irrigation and the use of lipid emulsions. MÉD.UIS. 2020;33(2)117-121.