Exploring the expression profile of vitamin D receptor and its related long non-coding RNAs in patients with acute lymphoblastic leukemia
Rev. Assoc. Med. Bras. (1992)
; 67(8): 1113-1117, Aug. 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1346981
Biblioteca responsável:
BR1.1
ABSTRACT
SUMMARY OBJECTIVE:
Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer. Previous studies have indicated the involvement of vitamin D receptor (VDR) and related long noncoding RNAs (lncRNAs) signaling in the pathophysiology of several cancers. However, their contribution to ALL remains to be elucidated.METHODS:
In this case-control study, 30 patients with newly diagnosed ALL and 30 age- and sex-matched healthy children were selected. Then, the level of 25(OH) vitamin D and the expression of VDR and four VDR-related lncRNAs were assessed.RESULTS:
No significant difference in serum 25(OH) vitamin D was observed between patients with ALL (20.42±6.5 ng/mL) and healthy subjects (25.45±11 ng/mL). In addition, the expression of MALAT-1, HOTAIR, and P-21 was not statistically significant between the two groups. However, a significant reduction in VDR and H19 expression was observed in patients with ALL (p<0.05).CONCLUSIONS:
25(OH) vitamin D insufficiency was evident in both groups. VDR and H19 signaling might be contributed to the pathogenesis of ALL, which needs further investigations.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Receptores de Calcitriol
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
RNA Longo não Codificante
Tipo de estudo:
Estudo observacional
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Rev. Assoc. Med. Bras. (1992)
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Irã
Instituição/País de afiliação:
Department of Clinical Biochemistry, Faculty of Medicine/IR
/
Department of Hematology and Blood Banking/IR
/
Student Research Committee/IR