Higher Concentration of Taenia Antigens in the CSF is Related to Slight Ventricle Enlargement and Periventricular Neuronal Decrease in Young Rats
Arq. bras. neurocir
; 40(2): 146-151, 15/06/2021.
Artigo
em Inglês
| LILACS
| ID: biblio-1362220
Biblioteca responsável:
BR1.1
ABSTRACT
Purpose Experimental models might help understand the pathophysiology of neurocysticercosis-associated hydrocephalus. The present study aimed to compare the extent of hydrocephalus and tissue damage in rats with subarachnoid inoculation of different concentrations of Taenia crassiceps cyst proteins. Methods Sixty young rats were divided into two groups: low- and high-concentration groups. The animals in the low concentration group received 0.02ml of 2.4mg/ml T. crassiceps cyst proteins while those in the high concentration group received 0.02 ml of 11.6mg/ml T. crassiceps cyst proteins. The animals underwent magnetic resonance imaging at 1, 3, and 6 months postinoculation to assess the ventricle volume. Morphological assessment was performed at the end of the observation period. Results Repeated measures of ventricle volumes at 1, 3, and 6 months showed progressive enlargement of the ventricles. At 1 and 3 months, we observed no differences in ventricle volumes between the 2 groups. However, at 6 months, the ventricles were larger in the high concentration group (median » 3.86mm3, range: 2.3712.68) compared with the low concentration group (median » 2.00mm3, range: 0.3711.57), p » 0.003. The morphological assessment revealed a few inflammatory features in both groups. However, the density of oligodendrocytes and neurons within the periventricular region was lower in the high concentration group (5.18 versus 9.72 for oligodendrocytes and 15.69 versus 21.00 for neurons; p < 0.001 for both). Conclusion Our results suggest that, in rats, a higher concentration of T. crassiceps cyst proteins in the subarachnoid space could induce ventricle enlargement and reduce the number of neurons within the periventricular area.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
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ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
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Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
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Doenças Negligenciadas
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Zoonoses
Base de dados:
LILACS
Assunto principal:
Ventrículos Cerebrais
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Neurocisticercose
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Hidrocefalia
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Antígenos de Helmintos
Limite:
Animais
Idioma:
Inglês
Revista:
Arq. bras. neurocir
Assunto da revista:
Cirurgia
/
Neurocirurgia
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Sciences, Universidade Estadual Paulista/BR
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Department of Neurology, Psychology and Psychiatry, Botucatu Medical School , Universidade Estadual Paulista/BR
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Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, Universidade de São Paulo/BR