Influence of antidepressant drugs on DNA methylation of ion channels genes in blood cells of psychiatric patients
Epigenomics (Online)
; 14(14)July 2022.
Artigo
em Inglês
| CONASS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1381722
Biblioteca responsável:
BR79.1
ABSTRACT
ABSTRACT AIM:
This study investigated the influence of antidepressant drugs on methylation status of KCNE1, KCNH2 and SCN5A promoters and ECG parameters in adult psychiatric patients. MATERIALS &METHODS:
Electrocardiographic evaluation (24 h) and blood samples were obtained from 34 psychiatric patients before and after 30 days of antidepressant therapy. Methylation of promoter CpG sites of KCNE1, KCNH2 and SCN5A was analyzed by pyrosequencing.RESULTS:
Three CpG and four CpG sites of KCNE1 and SCN5A, respectively, had increased % methylation after treatment. Principal component analysis showed correlations of the methylation status with electrocardiographic variables, antidepressant doses and patient age.CONCLUSION:
Short-term treatment with antidepressant drugs increase DNA methylation in KCNE1 and SCN5A promoters, which may induce ECG alterations in psychiatric patients.
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Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
CONASS
/
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Antidepressivos
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Epigenomics (Online)
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Department of Clinical e Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo/BR
/
Department of Electrophysiology & Cardiac Arrhythmias, Institute Dante Pazzanese of Cardiology/BR
/
Department of Teaching & Research, Real e Benemerita Associação Portuguesa de Beneficiência/BR
/
Institute of Exact Sciences, Federal University of Alfenas/BR
/
Institute of Psychiatry, School of Medicine, University of São Paulo/BR
