A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures
Braz. j. oral sci
; 21: e226585, jan.-dez. 2022. ilus
Artigo
em Inglês
| LILACS, BBO - Odontologia
| ID: biblio-1393018
Biblioteca responsável:
BR218.1
ABSTRACT
Aim:
This study aimed to systematically review existing literature regarding the association between dental proceduressuch as tooth extractions and periodontal therapyand occurrence of medication-related osteonecrosis of the jaw (MRONJ) in individuals using bone-modifying drugs.Methods:
Search strategies were performed in PubMed, Scopus, Web of Science and Cochrane Library for a timeframe ending in December 2021. Study selection, data extraction and risk of bias were analyzed independently by two researchers. Three meta-analyses were performed, estimating the crude risk ratio (RR), the adjusted odds ratio (OR) and the adjusted hazard ratio (HR) for the association between tooth extraction and MRONJ.Results:
Of the 1,654 studies initially retrieved, 17 were ultimately included. The majority of patients with MRONJ in these studies were female, with a mean age of 64 years. Zoledronic acid was the most commonly used drug among patients with MRONJ, and cancer was the most frequent underlying health condition. Regarding the performed meta-analyses, crude and adjusted analyses demonstrated that tooth extraction increased the risk for MRONJ by 4.28 (95% confidence interval [95%CI] 1.7310.58), the OR for MRONJ by 26.94 (95%CI 4.17174.17), and the HR for MRONJ by 9.96 (95%CI 4.0424.55).Conclusion:
It was concluded that performing dental procedures, especially tooth extraction, in patients using bone-modifying drugs increased the risk of MRONJ occurrence and, therefore, should be avoided. Further studies, using adjusted data, are warranted
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
BBO - Odontologia
/
LILACS
Assunto principal:
Cirurgia Bucal
/
Conservadores da Densidade Óssea
/
Osteonecrose da Arcada Osseodentária Associada a Difosfonatos
/
Mandíbula
Tipo de estudo:
Revisão sistemática
Idioma:
Inglês
Revista:
Braz. j. oral sci
Assunto da revista:
Odontologia
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Arthur Sá Earp Neto University/BR
/
Federal University of Pelotas/BR