Stress-another possible mechanism of neurotoxicity in neurodegenerative diseases
Int. j. high dilution res
; 21(1): 29-30, May 6, 2022.
Artigo
em Inglês
| LILACS, HomeoIndex - Homeopatia
| ID: biblio-1396556
Biblioteca responsável:
BR926.1
ABSTRACT
Theliteratureassociatesoxidativestresswiththeproductionoffreeradicals,whichleadtoneurodegeneration.Theypresentinnumerablehypotheses,amongwhichareabnormalitiesinthefunctioningofthehypothalamic-pituitary-adrenalaxis,neurotoxiceffectsandneuronaloxidativedamage.ClinicalobservationhasshownthatinneurodegenerativediseasessuchasMultipleSclerosis(MS)andAmyotrophicLateralSclerosis(ALS)thereisareportofprolonged or violent emotionalstressprecedingthesymptoms.Aims:
UsingtheCarilloComplexSystemsModel,presentsomepossibilitiesonhowstresscancontributetoneurodegeneration.Methodology:
NinecasesofALSandsixcasesofMSwereevaluated,pathologiesalreadyclassifiedasbelongingtosyphilinism.Literaturereviewonstressandneurotoxicitycarriedout.Resultsanddiscussion:
Syphilinism is instability with a predominantly intrinsicorigin to the system with a chronic caracter.This diathesis is characterized by a dissipative deficiency, predominantly hepatic, to the processing of certain elements or potentially toxic substances with exogenous origin or endogenous Such non-processed substances are unstable factors in the system, with greater affinity for certain tissues,like the nervous system. Among the toxins, we find alcohol, esters, formaldehyde, aloe, ketones, aldehydes, etc. The final hepatic metabolism of cortisol results in cortic acids and cortol, which use the same enzymatic system as alcohol, and can be considered syphilinic toxins. Ethanol can act directly at the circadian rhythm, disrupting it and generating stressful substances such as cortisol, regardless of an external event, increasing the toxin level. The inflammatory process generated by the production of free radicals and metabolic abnormalities, including the reduction of neuropeptide Y that modulates inflammatory activity in the nervous system, leads to changes that can result in neurodegeneration.Conclusion:
Inflammation caused by toxins from prolonged/violent emotional stress can lead to several changes in syphilinic individuals, due to failure in the dissipative process, including neurodegeneration.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas
Problema de saúde:
Álcool
Base de dados:
HomeoIndex - Homeopatia
/
LILACS
Assunto principal:
Estresse Psicológico
/
Sifilinismo em Homeopatia
/
Doenças Neurodegenerativas
/
Síndromes Neurotóxicas
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Int. j. high dilution res
Assunto da revista:
Homeopatia
/
Terapias Complementares
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Portugal
Instituição/País de afiliação:
ABRAH/BR
/
Hospital do Servidor Público Municipal de São Paulo/BR
/
UFF/BR
/
UFRJ/BR
/
UNB/BR
/
University of Évora/PT