Evolution of the prevalence and antimicrobial resistance among Escherichia coli isolated as a cause of infection in patients admitted to a iv-level hospital in Lima, Peru
Rev. patol. trop
; 51(3): 1-16, 2022. tab. ilus
Artigo
em Inglês
| LILACS
| ID: biblio-1417997
Biblioteca responsável:
BR15.1
Localização: BR15.1
ABSTRACT
The levels and evolution of antimicrobial resistance of Escherichia coli during 01/2009-06/2010 (Period 1), 01/2012-06-2013 (Period 2) and 07/2013-12/2014 (Period 3) were analyzed. Identification, susceptibility levels to 13 antibiotics and the presence of extendedspectrum ß-lactamases (ESBLs) were determined. Overall, 9,918 microorganisms were isolated as a cause of infection. Of these 3,016 (30.4%) were E. coli, with 1,770 (59%), 992 (33%) and 254 (8%), from the Medicine and the Surgery Departments and the Intensive Care Unit (ICU), respectively. There was a significant increase (p=0.0002) of E. coli throughout considered periods. The isolates presented high levels of resistance (>60%) to cephalosporins, ciprofloxacin and cotrimoxazole, being only susceptible to imipenem (0.3% of resistance) and tigecycline. Overall the analysis of evolution of antimicrobial resistance showed that resistance to cephalosporins and amikacin significantly increased, while, the ones of piperacillintazobactam, cotrimoxazole and gentamicin had significantly decreased. Nevertheless, the ICU isolates showed an inverse scenario for cephalosporins. These findings agree with an increase of ESBLs on the Medicine (56% to 66%; p<0.0001) and on the Surgery (54% to 62%; p=0.0197) departments, with a parallel decrease in the ICU (76% to 68%). In summary, high levels of antimicrobial resistance have been reported among E. coli, with worrisome levels of ESBL. A continuous surveillance of antimicrobial resistance levels in the area is needed.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doenças Negligenciadas
/
Zoonoses
Base de dados:
LILACS
Assunto principal:
Resistência Microbiana a Medicamentos
/
Ciprofloxacina
/
Cefalosporinas
/
Escherichia coli
/
Tigeciclina
/
Infecções
/
Unidades de Terapia Intensiva
/
Antibacterianos
Tipo de estudo:
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
País/Região como assunto:
América do Sul
/
Peru
Idioma:
Inglês
Revista:
Rev. patol. trop
Assunto da revista:
Medicina Tropical
/
Patologia
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Peru
Instituição/País de afiliação:
Hospital Nacional Guillermo Almenara Irigoyen/PE
/
Instituto Nacional de Salud/PE
/
Ministerio de Salud/PE
/
Universidad Científica del Sur/PE
/
Universidad Peruana Union/PE