Use of hyaluronic acid associated with triamcinolone acetonide or ozone gas in the treatment of induced osteoarthritis in rabbits
Acta cir. bras
; 36(12): e361201, 2021. ilus
Artigo
em Inglês
| LILACS, VETINDEX
| ID: biblio-1456246
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
Purpose:
To evaluate the effects of the intra-articular application of hyaluronic acid associated with triamcinolone acetonide, and ozone gas in the treatment of induced osteoarthritis in rabbits stifles.Methods:
Twenty-one Norfolk rabbits were submitted to cranial cruciate ligament transection of the left stifle. After six weeks of the surgery, the rabbits were randomized assigned into three groups G1 (control) saline solution (0.9%); G2 hyaluronic acid associated with triamcinolone; G3 ozone gas, submitted to three intra-articular applications every seven days.Results:
Significant differences occurred osteophytes at medial femoral condyle (G2 > G1, G2 > G3) on radiography exam; thickening of the medial condyle (G1 > G3, G2 > G3) on ultrasound exam; osteophytes at lateral tibial condyle (G2 > G1, G2 > G3), and medial femoral condyle (G1 > G2, G3 > G1) on computed tomography. Histologically, mean values of chondrocytes in the femur and tibia in G3 and G2 were statistically lower.Conclusions:
The intra-articular injection of hyaluronic acid associated with triamcinolone accentuated degenerative joint disease by imaging and macroscopic evaluations, and by histological findings, this treatment and the ozone gas treatment showed similar effects and were inferior to the saline solution (0.9%).
Texto completo:
Disponível
Base de dados:
LILACS
/
VETINDEX
Assunto principal:
Ozônio
/
Triancinolona Acetonida
/
Osteoartrite do Joelho
/
Ácido Hialurônico
Tipo de estudo:
Fatores de risco
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Ano de publicação:
2021
Tipo de documento:
Artigo
/
Documento de projeto
Instituição/País de afiliação:
Bioethicus Institute/BR
/
Universidade Estadual Paulista/BR
/
Universidade de São Paulo/BR