Early diagnosis of preeclampsia using placental growth factor: An operational pilot study in Maputo, Mozambique
Pregnancy hypertension (Online)
; 11: 26-31, jan. 2018. ilus
Artigo
em Inglês
| RDSM
| ID: biblio-1532590
Biblioteca responsável:
MZ1.1
ABSTRACT
n well-resourced settings, reduced circulating maternal free placental growth factor (PlGF) aids in either predicting or confirming the diagnosis of preeclampsia, fetal growth restriction, stillbirth, preterm birth, and delivery within 14 days of testing when pre-eclampsia is suspected. This operational pilot implementation of maternal plasma PlGF in women with suspected preeclampsia was conducted in six antenatal clinics in Maputo, Mozambique (six control clinics for comparison). The primary outcome was transfer to higher levels of care, following the informative PlGF assay. Of antenatal visits, 133/31,993 (0.42%) and 20/33,841 (0.06%) resulted in pre-eclampsia-related transfers of care for women attending intervention and control clinics, respectively (p < .0001). The clinic-to-delivery for women with low PlGF (<100 pg/ml) interval was shorter, (vs normal PlGF (median 10 days [IQR 1-25] vs 36 [11-83], p < .0001)). Low PlGF was associated with younger maternal age, higher blood pressure, earlier delivery, more therapeutic interventions, preterm birth, lower birth weight, and perinatal loss. In addition, one-third of hypertensive women with PlGF < 50 pg/ml suffered a stillbirth. In urban Mozambican women with symptoms and/or signs suggestive of preeclampsia, low maternal plasma PlGF concentrations are associated with increased risks of adverse pregnancy outcomes, especially early delivery and stillbirth. Therefore, introducing PlGF into the clinical care of women with suspected preeclampsia was associated with increased transfers to higher levels of care; low PlGF (<100 pg/ml) was associated with increased maternal and perinatal risks. PlGF < 50 pg/ml is particularly associated with stillbirth in women with suspected preeclampsia.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Moçambique
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.8 Atingir a cobertura universal de saúde
/
Meta 3.1: Reduzir a mortalidade materna
/
Meta 3.7 Acesso universal aos serviços de saude reprodutiva
Base de dados:
RDSM
Assunto principal:
Pré-Eclâmpsia
/
Fator de Crescimento Placentário
Limite:
Adulto
/
Humanos
/
Recém-Nascido
/
Gravidez
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Pregnancy hypertension (Online)
Ano de publicação:
2018
Tipo de documento:
Artigo
Instituição/País de afiliação:
Department of Obstetrics and Gynaecology, University of British Columbia/CA
/
Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London/GB
/
Maternal, Newborn / Chid Health, Clinton Health Access Initiative/MZ
/
National Department of Public Health, Ministry of Health/MZ