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Role of apparent diffusion map in the evaluation of retinoblastoma
Spadoni, Viviane Souto; Conceição, Thaylla Maybe Bedinot da; Schaefer, Flávia da Costa; Ercolani, Daniel Schmidt; Maestri, Marcelo Krieger; Klaes, Amalia; Selistre, Simone Geiger; Reis, Fabiano; Duarte, Juliana Ávila.
Afiliação
  • Spadoni, Viviane Souto; Hospital de Clínicas de Porto Alegre. Ophthalmology Division. Porto Alegre. BR
  • Conceição, Thaylla Maybe Bedinot da; Hospital de Clínicas de Porto Alegre. Radiology Division. Porto Alegre. BR
  • Schaefer, Flávia da Costa; Hospital de Clínicas de Porto Alegre. Radiology Division. Porto Alegre. BR
  • Ercolani, Daniel Schmidt; Hospital de Clínicas de Porto Alegre. Radiology Division. Porto Alegre. BR
  • Maestri, Marcelo Krieger; Hospital de Clínicas de Porto Alegre. Ophthalmology Division. Porto Alegre. BR
  • Klaes, Amalia; Hospital de Clínicas de Porto Alegre. Radiology Division. Porto Alegre. BR
  • Selistre, Simone Geiger; Hospital de Clínicas de Porto Alegre. Pediatric Oncology. Porto Alegre. BR
  • Reis, Fabiano; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Department of Anesthesiology, Oncology and Radiology. Campinas. BR
  • Duarte, Juliana Ávila; Hospital de Clínicas de Porto Alegre. Radiology Division. Porto Alegre. BR
Arq. bras. oftalmol ; Arq. bras. oftalmol;87(2): e2021, 2024. tab, graf
Article em En | LILACS-Express | LILACS | ID: biblio-1533794
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT

Purpose:

This study aimed to analyze the association between magnetic resonance imaging apparent diffusion coefficient map value and histopathological differentiation in patients who underwent eye enucleation due to retinoblastomas.

Methods:

An observational chart review study of patients with retinoblastoma that had histopathology of the lesion and orbit magnetic resonance imaging with apparent diffusion coefficient analysis at Hospital de Clínicas de Porto Alegre between November 2013 and November 2016 was performed. The histopathology was reviewed after enucleation. To analyze the difference in apparent diffusion coefficient values between the two major histopathological prognostic groups, Student's t-test was used for the two groups. All statistical analyses were performed using SPSS version 19.0 for Microsoft Windows (SPSS, Inc., Chicago, IL, USA). Our institutional review board approved this retrospective study without obtaining informed consent.

Results:

Thirteen children were evaluated, and only eight underwent eye enucleation and were included in the analysis. The others were treated with photocoagulation, embolization, radiotherapy, and chemotherapy and were excluded due to the lack of histopathological results. When compared with histopathology, magnetic resonance imaging demonstrated 100% accuracy in retinoblastoma diagnosis. Optic nerve invasion detection on magnetic resonance imaging showed a 66.6% sensitivity and 80.0% specificity. Positive and negative predictive values were 66.6% and 80.0%, respectively, with an accuracy of 75%. In addition, the mean apparent diffusion coefficient of the eight eyes was 0.615 × 103 mm2/s. The mean apparent diffusion coefficient value of poorly or undifferentiated retinoblastoma and differentiated tumors were 0.520 × 103 mm2/s and 0.774 × 103 mm2/s, respectively.

Conclusion:

This study revealed that magnetic resonance imaging is useful in the diagnosis of retinoblastoma and detection of optic nerve infiltration, with a sensitivity of 66.6% and specificity of 80%. Our results also showed lower apparent diffusion coefficient values in poorly differentiated retinoblastomas with a mean of 0.520 × 103 mm2/s, whereas in well and moderately differentiated, the mean was 0.774 × 103 mm2/s.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Arq Bras Oftalmol / Arq. bras. oftalmol / Arq. bras. oftalmol. (Online) / Arquivos brasileiros de oftalmologia (Impresso) Assunto da revista: OFTALMOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: Arq Bras Oftalmol / Arq. bras. oftalmol / Arq. bras. oftalmol. (Online) / Arquivos brasileiros de oftalmologia (Impresso) Assunto da revista: OFTALMOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil