Novel sustained-release of Stryphnodendron obovatum leaves extract using natural rubber latex as carrier
Rev. ciênc. farm. básica apl
; 36(3): 379-384, 01/07/2015. tab, ilus
Artigo
em Inglês
| LILACS
| ID: biblio-2564
Biblioteca responsável:
BR1851.9
ABSTRACT
Natural rubber latex biomembranes (NRL), obtained from rubber tree Hevea brasiliensis (Willd. ex A. Juss.) Mull. Arg., have been used as sustained drug release of drugs and plant extracts with medicinal properties. The Stryphnodendron obovatum Bench (Fabaceae), popularly known as "barbatimão" has anti-inflammatory and healing properties already described in literature. Thus, the aim of this work were to study the release behavior of the hydroethanolic extract from the leaves of S. obovatum loaded in the NRL by ultravioletvisible spectroscopy (UV-VIS). The release followed a biexponential pattern and the mechanism of release was Super Case II (n > 1). FTIR analyses did not show reaction between NRL and extract, only intermolecular interaction. From SEM was possible to observe the extract at the surface, responsible for the initial fast release, which the concentrations at 5.0 mg/mL released 2.4% and at 0.1 mg/mL released 96.8%; both reached the plateau in 7 days.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Borracha
/
Taninos
/
Stryphnodendron barbatimam
Idioma:
Inglês
Revista:
Rev. ciênc. farm. básica apl
Assunto da revista:
Farmacologia
Ano de publicação:
2015
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual Paulista (UNESP)/BR