Dangerous universal donors: the reality of the Hemocentro in Belo Horizonte, Minas Gerais
Rev. bras. hematol. hemoter
; 38(3): 193-198, 2016. tabela, gráfico
Artigo
em Inglês
| LILACS
| ID: biblio-834154
Biblioteca responsável:
BR408.1
Localização: BR408.1
ABSTRACT
Background: The term dangerous universal blood donor refers to potential agglutination of the erythrocytes of non-O recipients due to plasma of an O blood group donor, which contains high titers of anti-A and/or anti-B hemagglutinins. Thus, prior titration of anti-A and anti-B hemagglutinins is recommended to prevent transfusion reactions. Objective: The aim ofthis study was to estimate the frequency of dangerous universal donors in the blood bank of Belo Horizonte (Fundac¸ão Central de Imuno-Hematologia Fundac¸ão Hemominas Minas Gerais) by determining the titers of anti-A and anti-B hemagglutinins in O blood group donors. Method: A total of 400 O blood group donors were randomly selected, from March 2014 to January 2015. The titers of anti-A and anti-B hemagglutinins (IgM and IgG classes) were obtained using the tube titration technique. Dangerous donors were those whose titers of anti-A or anti-B IgM were ≥128 and/or the titers of anti-A or anti-B IgG were ≥256. Donors were characterized according to gender, age and ethnicity. The hemagglutinins were characterized by specificity (anti-A and anti-B) and antibody class (IgG and IgM). Results: Almost one-third (30.5%) of the O blood group donors were universal dangerous. The frequency among women was higher than that of men (p-value = 0.019; odds ratio: 1.66; 95% confidence interval: 1.082.56) and among young donors (1829 years old) it was higher than for donors between 49 and 59 years old (p-value = 0.015; odds ratio: 3.05; 95% confi- dence interval: 1.227.69). There was no significant association between dangerous universal donors and ethnicity, agglutinin specificity or antibody class. Conclusion: Especially platelet concentrates obtained by apheresis (that contain a substantial volume of plasma), coming from dangerous universal donors should be transfused in isogroup recipients whenever possible in order to prevent the occurrence of transfusion reactions
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Doadores de Sangue
/
Transfusão de Sangue
/
Imunoglobulina G
/
Imunoglobulina M
/
Serviço de Hemoterapia
/
Reação Transfusional
/
Hemaglutininas
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Fundação Central de Imuno-Hematologia/BR
/
Universidade Federal de Minas Gerais/BR